Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus

Scragg, Robert; Holdaway, I. M.; Singh, Vijay Kumar; Metcalf, Patricia; Baker, John; Dryson, Evan

doi:10.1016/0168-8227(95)01040-k

Cited by 253 publications

(195 citation statements)

References 43 publications

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“…Various studies suggested that decrease vitamin D level is increased insulin resistance in adults. [8][9][10][11] Findings of the present study show that insulin resistance was significantly higher in obese children compare to healthy children. However, there was an insignificant difference of HOMA-IR in comparison of deficient, insufficient and sufficient level of vitamin D in obese children.…”

Section: Discussionsupporting

confidence: 52%

“…These findings are consistent with the previous study of Hatun S et al, [8] Kadowaki S et al and Lee S ea al in which they observed a siginificant decrease of vitamin D in obese children compare to non-obese children. [9,10] Similarly, Scragg R et al, 11 Holick MF et al, [12] and Reis AF et al, [13] recorded significantly low vitamin D in comparison of higher BMI. This decrease of vitamin D in obese children may be due low quality food.…”

Section: Discussionmentioning

confidence: 99%

“…[9,10] Vitamin D is considered very important for insulin secretion and sustain the normal glucose homeostasis. [11] Reports recorded it also has an important role in paracrine and autocrine in adipose tissue. [12,13] The relationship of vitamin D, obesity and insulin resistance is still not clear in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D and its Relation with Insulin Resistance in Obese Children

Mathur¹,

Soni²,

Kukreja³

2018

AIMDR

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Background: Deficiency of vitamin D leads to mal skeletal growth in children; moreover it is becoming an epidemic throughout the world. Decrease level of vitamin D can cause diverse of skeletal disorders in children like rickets, osteopenia etc. The relationship of vitamin D, obesity and insulin resistance is still not clear in the literature. Vitamin D deficiency may induce the altered glucose tolerance in obese children. Therefore the present study was designed to investigate the relationship of vitamin D and insulin resistance in obese children. Methods: The present study was a cross sectional type of study which was conducted in paediatric department of TMMC & RC, Moradabad. This study included 120 obese children (60 males and 60 females) of mean age 12 ± 2.6 years in group I. Control group II contained 100 healthy none obese children (50 males and 50 females) of 12.2 ± 1.8 years. Insulin resistance was calculated from fasting plasma measurements using HOMA-IR (insulin (mU/L) × glucose (mmol/l)/22.5). Insulin resistance criteria were HOMA-IR >2.5 for children. Vitamin D was measured by ELISA method (kit manufactured by Cayman chemical company, Ann Arbor, USA). Results: There was an insignificant difference in the FBG (>0.05) of group I obese children and group II control. Insulin (<0.05) and HOMA-IR (<0.01) were significantly low in obese children in comparison of none-obese children. Vitamin D (<0.01) was significantly lower in obese children compare to healthy children. vitamin D was negatively correlated with BMI (r = -0.42, r2 =0.1764, p<0.05) in obese children. There was a negative correlation between vitamin D and insulin resistance (r = -0.52, r2 =0.2704, p<0.05) in obese children. Conclusion: Present study suggests that there was strong relation between insulin resistance and obesity. Vitamin D was negatively correlated with BMI and insulin resistance. These findings strongly suggest vitamin D level may found insufficient or deficient in obese children. Therefore, obese children should be screened for vitamin D deficiency for their normal skeletal growth.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

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Vitamin D and its Relation with Insulin Resistance in Obese Children

Mathur¹,

Soni²,

Kukreja³

2018

AIMDR

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“…Low vitamin D levels are common in patients with type 2 diabetes [1], over 50% of whom have a serum 25 hydroxyvitamin D (25OHD) level of <50 nmol/l [2,3]. Low vitamin D levels are associated with a higher risk of developing type 2 diabetes [4], worse glycaemic control in type 2 diabetes, higher serum lipid levels and a higher prevalence of cardiovascular disease [3].…”

Section: Introductionmentioning

confidence: 99%

The effect of different doses of vitamin D3 on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial

et al. 2010

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Aims/hypothesis Low 25-hydroxyvitamin D levels predict future cardiovascular events and are common in patients with type 2 diabetes. We compared the effect of 100,000 and 200,000 IU doses of vitamin D 3 on endothelial function, blood pressure and markers of glycaemic control in patients with type 2 diabetes. Methods This was a randomised, parallel group, placebocontrolled trial. Patients with type 2 diabetes and baseline 25-hydroxyvitamin D levels <100 nmol/l were enrolled from community and hospital-based diabetes clinics. Participants were assessed in a university department of clinical pharmacology and received a single oral dose of placebo or vitamin D 3 (100,000 IU or 200,000 IU) at baseline, randomly allocated via numbered bottles prepared offsite; participants and investigators were both blinded to treatment allocation. Endothelial function, office blood pressure, B-type natriuretic peptide, insulin resistance and glycosylated haemoglobin were measured at baseline, and at 8 and 16 weeks.

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“…In the Medical Research Council Ely Prospective Study, Forouhi et al (37) reported that s25(OH)D concentrations at baseline were inversely related with 10-year risk of hyperglycaemia, insulin resistance and the MetS. In a systematic review by Pittas et al (45) using data from four studies (57,58,79,81) , a summary OR for the association between s25(OH)D and type 2 diabetes of 0·54 (95 % CI 0·23, 1·27) was reported for the highest s25(OH)D concentration (62·5 -95 nmol/l) v. the lowest (25 -57·5 nmol/l).…”

Section: Glucose and Insulin Metabolism And Type 2 Diabetesmentioning

confidence: 99%

Vitamin D and cardiometabolic health: a review of the evidence

Muldowney

Kiely

2010

Nutr. Res. Rev.

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The cardiometabolic syndrome (MetS) is a clustering of related metabolic abnormalities including abdominal adiposity, insulin resistance, hypertension, dyslipidaemia and increased inflammatory and thrombotic markers, which is linked to increased risk of type 2 diabetes, CVD and overall mortality. Several cross-sectional and prospective studies have shown an association between low vitamin D status, as indicated by concentrations of serum 25-hydroxyvitamin D (s25(OH)D), and increased prevalence of the MetS and individual CVD risk factors. These epidemiological observations are supported by mechanistic studies but experimental data are limited. The available data from intervention studies are largely confounded as most vitamin D supplementation trials were mainly carried out to explore the role of Ca in CVD and include Ca in the treatment arms. Inadequate consideration of seasonal effects on s25(OH)D concentrations is also a common design flaw in most studies. Further complications arise from shared risk factors such as adiposity and ageing, which predispose individuals to exhibit both a more pronounced risk profile and relatively lower s25(OH)D concentrations. In conclusion, while epidemiological associations are promising and a rationale for low vitamin D status as a potentially modifiable risk factor for CVD is supported by mechanistic data, suitable experimental data from appropriately designed trials are just beginning to emerge. As yet, this body of literature is too immature to draw firm conclusions on the role of vitamin D in CVD prevention. Carefully controlled vitamin D trials in well-described population groups using intervention doses that are titrated against target s25(OH)D concentrations could yield potentially valuable outcomes that may have a positive impact on CVD risk modification.

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Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus

Cited by 253 publications

References 43 publications

Vitamin D and its Relation with Insulin Resistance in Obese Children

Vitamin D and its Relation with Insulin Resistance in Obese Children

The effect of different doses of vitamin D3 on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial

Vitamin D and cardiometabolic health: a review of the evidence

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