Serum 25-hydroxyvitamin D3 is associated with advanced glycation end products (AGEs) measured as skin autofluorescence: The Rotterdam Study

Chen, Jinluan; Duin, Daniel van der; Campos‐Obando, Natalia; Ikram, M. Arfan; Nijsten, Tamar; Uitterlinden, André G.; Zillikens, M. Carola

doi:10.1007/s10654-018-0444-2

Cited by 16 publications

(11 citation statements)

References 47 publications

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“…During the visit to the research center, skin autofluorescence was measured at the inner side of the dominant forearm using the AGE Reader device (DiagnOptics) based on the fluorescent property of AGEs. 24 The device has been validated against AGEs measured in skin biopsies from the same site where skin autofluorescence was measured. 17 Participants were asked not to use skin creams before the measurement.…”

Section: Methodsmentioning

confidence: 99%

Assessment of Advanced Glycation End Products and Receptors and the Risk of Dementia

et al. 2021

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IMPORTANCE Advanced glycation end products (AGEs) and their receptor (RAGE) are implicated in the pathophysiological processes of dementia and potentially underlie the association of diabetes with neurodegeneration. However, longitudinal studies examining this association are lacking. OBJECTIVE To determine whether markers of the AGE-RAGE system are associated with prevalent and incident dementia and with cognition. DESIGN, SETTING, AND PARTICIPANTS In this population-based cohort study including participants from the prospective Rotterdam Study, extracellular newly identified RAGE binding protein (EN-RAGE) and soluble RAGE (S-RAGE) were measured in plasma collected between 1997 and 1999 in a random selection of participants, and additionally in participants with prevalent dementia. Participants without dementia were followed up for dementia until 2016. Skin AGEs,

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Section: Methodsmentioning

confidence: 99%

Assessment of Advanced Glycation End Products and Receptors and the Risk of Dementia

et al. 2021

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“…During the visit to the RS research center, SAF of participants’ inner dominant forearm skin was measured using the AGE Reader device (DiagnOptics), and the value was expressed in arbitrary units (AU). Details of the measurement have been described previously ( 32 ). The device utilizes the fluorescent property of some AGEs ( 4 ) and has been validated previously against AGEs (pentosidine, CML, and CEL) measured in skin biopsies from the same site at which SAF was measured ( 4 ).…”

Section: Methodsmentioning

confidence: 99%

“…Results of CML intake are discussed in the Results section, and the results of the other 2 dietary AGEs are presented in the supplemental materials. Potential confounders were identified based on a combination of literature review and biological reasoning, such as increased AGE accumulation under diabetic or CKD conditions ( 32 ). Then we restricted covariates to the ones that are (proxy of) shared causes (risk factors) of dAGEs and SAF to remove redundancy and overfitting problems in the models ( 36 ).…”

Section: Methodsmentioning

confidence: 99%

The association between dietary and skin advanced glycation end products: the Rotterdam Study

Chen

Waqas

Tan

et al. 2020

The American Journal of Clinical Nutrition

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ABSTRACT Background Advanced glycation end products (AGEs) accumulate in tissues with age and in conditions such as diabetes mellitus and chronic kidney disease (CKD), and they may be involved in age-related diseases. Skin AGEs measured as skin autofluorescence (SAF) are a noninvasive reflection of long-term AGE accumulation in tissues. Whether AGEs present in the diet (dAGEs) contribute to tissue AGEs is unclear. Objectives Our aim was to investigate the association between dietary and skin AGEs in the Rotterdam Study, a population-based cohort of mainly European ancestry. Methods In 2515 participants, intake of 3 dAGEs [carboxymethyl-lysine (CML), N-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MGH1), and carboxyethyl-lysine (CEL)] was estimated using FFQs and the content of AGEs measured in commonly consumed foods. SAF was measured 5 y (median value) later using an AGE Reader. The association of dAGEs with SAF was analyzed in linear regression models and stratified for diabetes and chronic kidney disease (CKD, defined as estimated glomerular filtration rate ≤60 mL/min) status. Results Mean ± SD intake was 3.40 ±0.89 mg/d for CML, 28.98 ±7.87 mg/d for MGH1, and 3.11 ±0.89 mg/d for CEL. None of them was associated with SAF in the total study population. However, in stratified analyses, CML was positively associated with SAF after excluding both individuals with diabetes and individuals with CKD: 1 SD higher daily CML intake was associated with a 0.03 (95% CI: 0.009, 0.05) arbitrary units higher SAF. MGH1 and CEL intake were not significantly associated with SAF. Nevertheless, the associations were stronger when the time difference between dAGEs and SAF measurements was shorter. Conclusions Higher dietary CML intake was associated with higher SAF only among participants with neither diabetes nor CKD, which may be explained by high AGE formation in diabetes and decreased excretion in CKD or by dietary modifications in these disease groups. The dAGE–SAF associations were also modified by the time difference between measurements. Our results suggest that dAGEs can influence tissue AGE accumulation and possibly thereby age-related diseases. This trial was registered at the Netherlands National Trial Register as NTR6831 (http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=6831) and at the WHO International Clinical Trials Registry Platform as NTR6831 (http://www.who.int/ictrp/network/primary/en/).

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“…For additional EJE references please see [197][198][199][200][201][202][203][204][205][206][207][208].…”

Section: Future Perspectivesmentioning

confidence: 99%

Objectives, design and main findings until 2020 from the Rotterdam Study

et al. 2020

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The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical course, natural history and potential targets for intervention for chronic diseases in mid-life and late-life. The study focuses on cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1700 research articles and reports. This article provides an update on the rationale and design of the study. It also presents a summary of the major findings from the preceding 3 years and outlines developments for the coming period.

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Serum 25-hydroxyvitamin D3 is associated with advanced glycation end products (AGEs) measured as skin autofluorescence: The Rotterdam Study

Cited by 16 publications

References 47 publications

Assessment of Advanced Glycation End Products and Receptors and the Risk of Dementia

Assessment of Advanced Glycation End Products and Receptors and the Risk of Dementia

The association between dietary and skin advanced glycation end products: the Rotterdam Study

Objectives, design and main findings until 2020 from the Rotterdam Study

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