Serum 25-hydroxyvitamin D3 and body composition in an elderly cohort from Germany: a cross-sectional study

Jungert, Alexandra; Roth, Heinz Jürgen; Neuhäuser‐Berthold, Monika

doi:10.1186/1743-7075-9-42

Cited by 36 publications

(49 citation statements)

References 45 publications

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“…Our data on all subjects combined is consistent with the results of several publications that the vitamin D levels negatively correlate with BMI [16, 17]. We noted that a lower number of subjects with prostate cancer had diabetes in our study.…”

Section: Discussionsupporting

confidence: 93%

Vitamin D Levels in Subjects with Prostate Cancer Compared to Age-Matched Controls

2012

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Prostate cancer (PCa) is the second most common cancer in men worldwide and the second leading cause of cancer deaths in men in the United States. Vitamin D is considered to have anticancer properties, currently thought to work mainly through its nuclear receptor or vitamin D receptor. In this retrospective study, we compared vitamin D levels in subjects with PCa with those of age-matched men without PCa. Study subjects included 479 in each group with a mean age of 73 and a mean creatinine of 1.05 and 1.15. Levels of 25 (OH) vitamin D were 28.4 ± 0.54 and 28.05 ± 0.62 in subjects with and without PCa. Levels of 1,25 (OH) vitamin D were 47.2 ± 6.8 and 47.1 ± 7.11 in subjects with and without PCa. In contrast to other studies, we did not find a significant difference in vitamin D levels. Among prostate cancer patients, vitamin D levels correlated positively with age (r = 0.12, P < 0.02), and were negatively associated with BMI (r = −0.13, P = 0.003), glucose (r = −0.12, P < 0.007), HbA1C (r = −0.16, P = 0.001), and PTH (r = −0.21; P < 0.0001). The data do not show the causal effect of vitamin D levels on PCa.

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Section: Discussionsupporting

confidence: 93%

Vitamin D Levels in Subjects with Prostate Cancer Compared to Age-Matched Controls

2012

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“…2 Cross-sectional studies have confirmed the inverse association between 25(OH)D and body fat in older adults, 3 explicitly in women. 4 The underlying mechanism may be an increased uptake and storage of the fat soluble 25(OH)D in the expanded adipose tissue of obese subjects, 5 but results from basic studies indicate that 25(OH)D deficiency could also contribute to excess body fat through a variety of processes. 2,6 25(OH)D levels are usually low in older adults; 7 an evaluation of 25(OH)D deficiency as a risk factor for obesity is thus of special interest.…”

Section: Introductionmentioning

confidence: 99%

Association of serum vitamin D with change in weight and total body fat in a German cohort of older adults

et al. 2015

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We examined the association of baseline serum 25-hydroxyvitamin D (25(OH)D) with change in weight and total body fat in a cohort of community-dwelling older adults from Southern Germany. A total of 735 participants of the population-based KORA-Age Study (2009-2012), aged 65-90 years, were followed for 2.9±0.1 years. Body fat was assessed with bioelectrical impedance analysis. Linear and multinomial logistic models, adjusted for baseline covariables, were used to examine the association of 25(OH)D with percentage weight and body fat change during follow-up. 25(OH)D levels were not associated with overall weight change or body fat loss. Higher 25(OH)D levels were associated with a lower likelihood of having gained >3% of body fat in women but not in men. As we cannot exclude residual confounding by outdoor physical activity and diet, our results are not sufficient to support a causal role of 25(OH)D in the etiology of obesity in Caucasian older adults.

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“…Visceral adipose tissue is negatively associated with plasma 25OHD concentrations in South Asians [6]. Total body fat has been shown to be a negative predictor of 25OHD levels in women even after controlling for age, lifestyle, and PTH in Germany [7]. Vitamin D deficiency has been associated with obesity, visceral obesity, hypertriglyceridemia, and metabolic syndrome in Korean children [8].…”

Section: Introductionmentioning

confidence: 99%

The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms

Lương

Nguyễn

2013

Nutr J

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The prevalence rates of overweight and obesity are considered an important public issue in the United States, and both of these conditions are increasing among both children and adults. There is evidence of aberrations in the vitamin D-endocrine system in obese subjects. Vitamin D deficiency is highly prevalent in patients with obesity, and many studies have demonstrated the significant effect of calcitriol on adipocytes. Genetic studies have provided an opportunity to determine which proteins link vitamin D to obesity pathology, including the vitamin D receptor, toll-like receptors, the renin-angiotensin system, apolipoprotein E, vascular endothelial growth factor, and poly (ADP-ribose) polymerase-1. Vitamin D also exerts its effect on obesity through cell-signaling mechanisms, including matrix metalloproteinases, mitogen-activated protein kinase pathways, the reduced form of nicotinamide adenine dinucleotide phosphate, prostaglandins, reactive oxygen species, and nitric oxide synthase.In conclusion, vitamin D may have a role in obesity. The best form of vitamin D for use in the obese individuals is calcitriol because it is the active form of the vitamin D3 metabolite, its receptors are present in adipocytes, and modulates inflammatory cytokine expression.

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Serum 25-hydroxyvitamin D3 and body composition in an elderly cohort from Germany: a cross-sectional study

Cited by 36 publications

References 45 publications

Vitamin D Levels in Subjects with Prostate Cancer Compared to Age-Matched Controls

Vitamin D Levels in Subjects with Prostate Cancer Compared to Age-Matched Controls

Association of serum vitamin D with change in weight and total body fat in a German cohort of older adults

The beneficial role of vitamin D in obesity: possible genetic and cell signaling mechanisms

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