Serum 25-hydroxyvitamin D status in pregnant women with chronic hepatitis B virus infection

Abstract

Introduction: Maternal 25-hydroxyvitamin D [25(OH)D] deficiency has a negative influence on the health of the mother and the developing fetus. The aim of this study was to assess serum 25(OH)D status and its relationship to virologic and biochemical parameters in pregnant women with chronic hepatitis B virus (HBV) infection. Methodology: Serum 25(OH)D levels among 142 pregnant women with chronic HBV infection and 251 healthy pregnant women were measured using enzyme-linked immunosorbent assay. Results: The mean ± SD values for serum 25(OH)D levels were 13.63 ± 5.5 ng/mL in healthy pregnant women and 12.05 ± 3.3 ng/mL in pregnant women with chronic HBV infection (p < 0.01). Serum 25(OH)D levels were associated with seasonal variation in healthy pregnant women (p = 0.01); however, similar results were not observed in pregnant women with chronic HBV infection (p = 0.10). Furthermore, multivariate analysis indicated that only ALT level was independently associated with severe vitamin D deficiency (p = 0.01). A significant positive correlation was found between serum 25(OH)D level and ALT level in pregnant women with chronic HBV infection (r = 0.32; p < 0.001). Conclusions: Vitamin D levels were lower in pregnant women with chronic HBV infection compared with healthy pregnant women. Vitamin D supplementation can be routinely recommended for pregnant women in China.

Low vitamin D levels are associated with high viral loads in patients with chronic hepatitis B: a systematic review and meta-analysis

“…All the studies were observational studies. One study [28] only involved pregnant women and one only involved men [30]. Two studies [27, 29] involved HBV patients with different clinical stages, including CHB, cirrhosis and HCC.…”

“…All but one [24] of the studies reported the proportion of gender among CHB patients, yet no gender specific level of vitamin D was available. Four studies [24, 26, 28, 29] mentioned the seasons of blood sampling but the seasons were different from each other, and no seasonally fluctuation was showed in Chen’s study which extensively addressed the seasonality of serum vitamin D [26]. Only one study [26] reported HBV genotype.…”

“…Only one study [26] reported HBV genotype. Two studies [26, 29] explored the differences of vitamin D level per HBeAg status and showed paradoxical results, with another study [28] indicating a comparable frequency of vitamin D deficiency. Thus no specific subgroup analyses about aforementioned items have been done.…”

“…Five studies [25–28, 30] reported the proportion of patients with vitamin D deficiency (< 20 ng/mL) in CHB groups. And the pooled prevalence of vitamin D deficiency was 56% (95% CI: 23–89) (Fig.…”

Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease

“…Vitamin D is a fat-soluble vitamin and is activated in the liver and kidney [ 8 ]. Activated vitamin D [1,25(OH) 2 D] can promote the differentiation of monocytes and inhibit the maturation of dendritic cells [ 9 ].…”