Serum 25-hydroxyvitamin D levels in a healthy population from the North of Portugal

Bettencourt, Andreia; Boleixa, Daniela; Reis, Joel; Oliveira, José Carlos; Mendonça, Denisa; Costa, Paulo; Silva, Ana Martins; Marinho, António; Silva, Ana Martins da

doi:10.1016/j.jsbmb.2016.11.005

Cited by 25 publications

(13 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, vitamin D levels are generally higher in summer than in winter, which may be related to UV intensity. 26,27 Vitamin D, as the main regulator of calcium and phosphorus metabolism, plays an important role in maintaining intracellular and extracellular calcium homeostasis. In addition to its association with bone health, vitamin D is also associated with obesity, insulin resistance, diabetes, hypertension, atherosclerosis and other diseases.…”

Section: Relationship Between 25(oh)d Level and Glucose And Lipid Metmentioning

confidence: 99%

“…The relationship between vitamin D levels and obesity is inconsistent. Most studies suggested that vitamin D levels were lower in obese people, and negatively correlated with BMI 22,26,27,32 and WC. 30,32,34 The possible mechanism is that excessive vitamin D accumulates in the adipose tissue of obese people, leading to a decrease in vitamin D in the blood circulation and affecting its biological activity.…”

Section: Multiple Linear Regression Analysismentioning

confidence: 99%

See 1 more Smart Citation

<p>Vitamin D Status and Correlation with Glucose and Lipid Metabolism in Gansu Province, China</p>

Yang

Liu

et al. 2020

DMSO

View full text Add to dashboard Cite

Objective: To investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and blood glucose and lipid levels in people over 18 years of age in Gansu, China. Subjects and Methods: A total of 1928 volunteers (958 males and 970 females) were selected. The prevalence of abnormal glucose metabolism and lipid metabolism in the vitamin D deficiency group (<20 ng/mL) and the non-vitamin D deficiency group (≥20 ng/mL) were compared. The correlations between serum 25(OH)D and blood glucose and lipid were analyzed. Results: A total of 1681 patients had 25(OH)D deficiency, with an overall prevalence of 87.2% (82.9% in males and 91.4% in females). The levels of 25(OH)D in the diabetic group and the IGT/IFG group were significantly lower than that in the normal group. The level of 25(OH)D was significantly lower in the dyslipidemia group than that in the normal group, and was significantly lower in the fasting plasma glucose (FPG) ≥5.6 mmol/L group than that in the FPG <5.6 mmol/L group (p=0.002). The 25(OH)D level in the serum triglyceride (TG) ≥1.7 mmol/L group was significantly lower than that of the TG <1.7 mmol/L group (p=0.0274). The age, heart rate, TG, TC, FPG and H 2 PG levels in the vitamin D deficiency group were significantly higher than those in the non-vitamin D deficiency group (p<0.05). The prevalence of FPG ≥5.6 mmol/L in the vitamin D deficiency group was higher than that in the non-vitamin D deficiency group (23.5% vs 16.6%, p=0.016). Multiple linear regression analysis suggested that serum 25(OH)D levels were independently correlated with gender, age, FPG, TG and heart rate (β=−0.218, −0.129, −0.075, β=−0.103, −0.058, all p<0.05). Conclusion: The incidences of dyslipidemia and dysglycemia were higher in the vitamin D deficiency group. The vitamin D level was independently and negatively correlated with FPG and TC, but not with waist circumference, BMI and blood pressure.

show abstract

Section: Relationship Between 25(oh)d Level and Glucose And Lipid Metmentioning

confidence: 99%

Section: Multiple Linear Regression Analysismentioning

confidence: 99%

<p>Vitamin D Status and Correlation with Glucose and Lipid Metabolism in Gansu Province, China</p>

Yang

Liu

et al. 2020

DMSO

View full text Add to dashboard Cite

show abstract

“…A high prevalence of vitamin D deficiency has been reported not only in sick populations [1], particularly hospitalized patients, but also in healthy individuals, as demonstrated in a recent study that defines it as being pandemic in Europe [2]. A contemporary study [3], performed in the north of Portugal, in 2016, reported a prevalence of 48 and 74% of vitamin D deficiency in a healthy adult population (18-67 years), in summer and winter, respectively. There is evidence of an association between lower levels of vitamin D and higher risk of numerous diseases, such as cancer, mental disorders, infection, cardiovascular diseases, type 2 diabetes mellitus, and autoimmune disorders [4].…”

Section: Introductionmentioning

confidence: 97%

Vitamin D Deficiency in a Portuguese Cohort of Patients with Inflammatory Bowel Disease: Prevalence and Relation to Disease Activity

Branco

Cardoso

Anapaz

et al. 2018

GE Port J Gastroenterol

View full text Add to dashboard Cite

Background and Aims: Vitamin D deficiency is more common in inflammatory bowel disease (IBD) patients than in the general population. However, there are conflicting data about predictive factors of vitamin D deficiency and its potential association with disease activity. The aims of this study were to determine the prevalence and predictive factors of vitamin D deficiency and to evaluate a possible association with disease activity. Methods: A prospective observational study was conducted, including patients with IBD from January to July 2016. The Endocrine Society guidelines were considered for defining levels of serum 25-hydroxyvitamin D (25-OH-D) as follows: deficient (< 20 ng/mL, < 10 ng/mL being severe deficiency), insufficient (21–29 ng/mL), and adequate (> 30 ng/mL). Results: A total of 152 patients (52% men; 47.2 ± 17.3 years) were included, of whom 70% had Crohn’s disease (CD). Thirty-seven percent of patients were on immunosuppressors and 17% were on biologics. The majority were outpatients (88.2%). Mean 25-OH-D levels were 17.1 ± 8 ng/mL (CD: 16.7 ± 8 ng/mL vs. ulcerative colitis: 17.6 ± 7 ng/mL, p = 0.1). Inadequate levels were present in 90.8% of patients (deficiency: 68.4%; insufficiency: 22.4%). A significant negative correlation between 25-OH-D levels and age (r = –0.2, p = 0.04), C-reactive protein (CRP) levels (r = –0.22, p = 0.004), and Harvey-Bradshaw index (HBi) (r = –0.32, p = 0.001) was found. Patients with severe deficiency showed a higher CRP (0.6 vs. 1.4 mg/dL, p = 0.03), erythrocyte sedimentation rate (ESR) (22 vs. 31 mm/h, p = 0.03), and HBi (2 vs. 5, p < 0.001) and lower hemoglobin (13.6 vs. 12.7 g/dL, p = 0.02). There was no association between vitamin D deficiency and gender, type, extent, and duration of disease, surgery, and other measures of disease activity, such as ESR, hemoglobin (these 2 items except for severe deficiency), fecal calprotectin, or Truelove and Witts classification. Conclusions: There is a high prevalence of inadequate levels of vitamin D in IBD patients, particularly deficiency (68.4%). There seems to exist an association between lower levels of vitamin D and higher disease activity, especially in CD.

show abstract

“…The Portuguese population has a higher prevalence of sunburns compared to other southern countries, namely Italy and Greece, supporting the hypothesis of a more intense sun exposure [32]. Nevertheless, there is still an important vitamin D deficiency in the Portuguese population [33], and particularly in patients with MS [34]. Ethnic and racial distribution could also play a role in these results.…”

Section: Discussionmentioning

confidence: 68%

The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study

et al. 2020

View full text Add to dashboard Cite

Background The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north–south gradient of prevalence may be disappearing in the Northern hemisphere. The few previous prevalence studies performed in Portugal have reported a lower prevalence than the average for Western Europe. The aim of this study is to estimate the prevalence of MS in the Entre Douro e Vouga region, in Northern Portugal. Methods Multiple overlapping sources were used to ascertain all cases from the reference population: records from hospitals in the region and neighbouring regions; diagnostic databases of primary care physicians; and applications for disability benefits. The prevalence date was set at 1 January 2014. The reference population was 274,859 inhabitants. Patients’ neurologists were contacted to retrieve clinical information and confirm the diagnosis based. Results A total of 177 patients were identified after eliminating duplicates from different sources. The female to male ratio was 1.9 and the mean age at disease onset was 33.5 (standard deviation: 10.3). Clinically isolated syndrome accounted for 9.0% of patients, relapsing remitting for 58.8%, secondary progressive for 20.3% and primary progressive for 11.8%. The prevalence was estimated in 64.4 patients per 100,000 (95% confidence interval: 54.9;73.9). Conclusions In this study we report a higher point prevalence of MS than had been previously described in Portugal, but still far from the higher values recently reported in other Southern European countries.

show abstract

Serum 25-hydroxyvitamin D levels in a healthy population from the North of Portugal

Cited by 25 publications

References 24 publications

<p>Vitamin D Status and Correlation with Glucose and Lipid Metabolism in Gansu Province, China</p>

<p>Vitamin D Status and Correlation with Glucose and Lipid Metabolism in Gansu Province, China</p>

Vitamin D Deficiency in a Portuguese Cohort of Patients with Inflammatory Bowel Disease: Prevalence and Relation to Disease Activity

The epidemiology of multiple sclerosis in the entre Douro e Vouga region of northern Portugal: a multisource population-based study

Contact Info

Product

Resources

About