Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D?

Mansbach, Jonathan M.; Ginde, Adit A.; Camargo, Carlos A.

doi:10.1542/peds.2008-2041

Cited by 278 publications

(235 citation statements)

References 51 publications

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“…In children, vitamin D deficiency and insufficiency are important health problems and variable prevalences have been reported in studies conducted in many countries (8)(9)(10)(11). In a study conducted in Greece, vitamin D deficiency was found with a rate of 14% in children aged between three and 18 years (8).…”

Section: Discussionmentioning

confidence: 99%

“…In a study conducted in Greece, vitamin D deficiency was found with a rate of 14% in children aged between three and 18 years (8). In USA, vitamin D deficiency was found with a rate of 14% and vitamin D insufficiency was found with a rate of 63% in 1799 children aged between one and five years (9). In another study, vitamin D deficiency was found with a rate of 12% and vitamin D insufficiency was found with a rate of 40% in 133 infants aged between eight and 24 months (10).…”

Section: Discussionmentioning

confidence: 99%

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The effect of vitamin D on lower respiratory tract infections in children

Şişmanlar¹,

Aslan²,

Gülbahar³

et al. 2016

Turk Pediatri Ars

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Aim: Lower respiratory tract infections including mainly pneumonia represent an important public health problem leading to high mortality and mobidity rates in children aged below five years in developing countries including our country. Vitamin D deficiency has been associated with increased risk of rickets/osteomalacia, various cancers, autoimmune diseases, hyperproliferative skin diseases, cardiovascular system diseases and infectious diseases. Vitamin D has an important role in cellular and humoral immunity and pulmonary functions. Vitamin D deficiency and lower respiratory tract infection are common health problems in children in our country and no clinical study investigating the relationship between these problems has been conducted so far. In this case-control study, we aimed to assess the association between vitamin D level and lower respiratory tract infection in children. Material and Methods: Sixty-three children aged between six months and five years with lower respiratory infections and 59 age-matched children who had no history of respiratory symptoms in the last month and no accompanying chronic disease were compared in terms of vitamin D levels. The children in the patient group were also evaluated by the clinical picture. Results: No significant correlation was found between vitamin D levels and lower respiratory tract infection in terms of disease and its severity. However, it was found that vitamin D deficiency/ insufficiency was observed with a high rate in all children included in the study. Conclusions: Although no correlation was found between vitamin D level and lower respiratory tract infection, it is recommended that vitamin D level should be measured in children with lower respiratory tract infection and vitamin D supplementation should be given to all children especially in winter months based on the fact that the level of vitamin D was lower than normal in approximately half of the children included in the study and considering the effects of vitamin D on infections, pulmonary functions and immunity. (Turk Pediatri Ars 2016; 51: 94-9)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of vitamin D on lower respiratory tract infections in children

Şişmanlar¹,

Aslan²,

Gülbahar³

et al. 2016

Turk Pediatri Ars

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“…D vitamininin bu aktif formu enfeksiyon yanıtlarında lokal etkiye sahiptir, bu da enfeksiyonlara bağlı inflamasyonun azaltılmasında etkili olabilir (9). D vitamini özellikle solunum yolu patojenlerine karşı önemli bir antimikrobiyal peptid olan katelisidin ekspresyonunu artırarak immün sistem üzerine etki etmektedir (8,32). D vitamini edinsel kazanılmış bağışıklık sistemi üzerinde inhibitör sitokinlerin salınımını (IL-10 ve TGF-β) ve CD4+ T lenfositlerin (Th1 ve Th2) kontrolünü sağlayan düzenleyici T regülatuvar hücrelerin indüksiyonunu destekler.…”

Section: Astımlı çOcuklar Ve Kontrol Grubunun Laboratuvar Sonuçlarıunclassified

Effects of Vitamin D Levels on Asthma Control and Severity in Children

Türkeli¹,

Ayaz²,

Uncu³

et al. 2016

Asthma Allergy Immunol

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ÖZGiriş: Günümüzde astım ve vitamin D eksikliği prevalansı oranı paralel şekilde artmakta ve önemli morbiditelere neden olmaktadır. Çalışmanın amacı, serum D vitamini düzeylerini astımlı çocuklar ile sağlıklı kontroller arasında karşılaştırmak, D vitamini düzeylerinin astım klinik parametreleri ile ilişkisini ve astım kontrolü üzerine etkisini değerlendirmektir. Results: Serum vitamin D levels were 17.27 (5.77) ng/ml in the asthma group and 22.78 (10.64) ng/ml in the control group, indicating statistical significance (p= 0.001). When the asthma patients were divided into groups according to vitamin D level, 72.2% were deficient while 27.8% had adequate levels. The number of asthma exacerbations, number of emergency service visits and the number of hospitalizations within the last year were higher in the deficient group, compared to the adequate group (p <0.001, p Gereç ve

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“…In children, due to fewer outcome data, the optimal level of serum 25(OH)D for general health is not known yet. Moreover, it is controversial than in adults [20] As per above mentioned definitions, the prevalence of vitamin D insufficiency was higher among American children aged 6 -11 years (73%) compared with children aged 1 -5 years (63%); girls (71%) compared with boys (67%); and non-Hispanic black (92%) and Hispanic (80%) children compared with non-Hispanic white children (59%) [26]. Several other studies suggest that the prevalence of vitamin D insufficiency among children is 30% -50% in Australia, Turkey, India, and Lebanon [27] [28] [29].…”

Section: Introductionmentioning

confidence: 99%

High Prevalence of Vitamin D Deficiency among Bangladeshi Children: An Emerging Public Health Problem

Zaman¹,

Hawlader²,

Biswas³

et al. 2017

Health

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Background: Recent studies suggested that vitamin D deficiency among children is widespread worldwide. Most of the Asian countries are suffering from high prevalence of vitamin D deficiency, especially in children. However, the vitamin D deficiency of Bangladeshi children has not been investigated yet. The objective of the study was to assess the prevalence of vitamin D deficiency among children in Dhaka city, Bangladesh. Methods: A cross-sectional study was designed. Children aged 0 month to 16 years attended Pediatrics' clinics with minor illness were conveniently recruited. After obtaining informed written consent, venous blood was taken and serum 25(OH)D levels were determined by direct enzyme-linked immunosorbent assay. Descriptive statistics were performed for age, sex, biochemical parameters. Socio-economic status (SES) was estimated using a wealth index, producing a weighted score. Scores were categorized into quintiles, with category 1 representing the poorest and category 5 the richest. Serum 25(OH)D was categorized: deficient as <10 ng/ml, insufficient as 10 -29 ng/ml and sufficient as 30 -100 ng/ml. Results: 31.88% children of 0 -1 year had deficient serum 25(OH)D level and 52.17% children had insufficient level. Among 2 -5 years' group, 38.16% were deficient and 50% were insufficient. Among the 6 -11 years group, 41.02% were deficient and 52.56% were insufficient. Among 12 -16 years group, 46.75% were deficient and 51.95% were insufficient. That means, serum 25-hydroxyvitamin D deficiency and insufficiency rate is found very high among Bangladeshi children. Conclusions: The prevalence of vitamin D deficiency and insufficiency among children in Bangladesh is high. The study recommended that vitamin D supplementation in Bangladeshi children should be formally launched from first day of birth up to adolescence.

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Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D?

Cited by 278 publications

References 51 publications

The effect of vitamin D on lower respiratory tract infections in children

The effect of vitamin D on lower respiratory tract infections in children

Effects of Vitamin D Levels on Asthma Control and Severity in Children

High Prevalence of Vitamin D Deficiency among Bangladeshi Children: An Emerging Public Health Problem

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