Serum 25-Hydroxyvitamin D Is Associated with Reduced Risk of Metabolic Syndrome at 5 Years: Results from a National, Population-Based Prospective Study (The Australian Diabetes, Obesity and Lifestyle Study — AusDiab)

Gagnon, Claudia; Lu, Zhong X.; Magliano, Dianna J.; Dunstan, David W.; Shaw, Jonathan E.; Zimmet, Paul; Sikaris, Ken; Grantham, Narelle; Ebeling, Peter R.; Daly, Robin M.

doi:10.1210/endo-meetings.2011.part2.p26.p2-119

Cited by 4 publications

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“…18 Data from an Australian diabetes, obesity and lifestyle study suggest that 25(OH)D levels were low in diabetics and that there was an inverse association between 25(OH)D and type 2 diabetes risk in the general population. 19 Vitamin D deficiency can be caused by inefficient synthesis in the skin due to improper exposure to sunlight or type of skin or other factors, 5 though in this study, there was no statistical difference of sunlight exposure between the diabetic and non-diabetic group (p=0.79), 15 minutes and 30 minutes sunlight exposure in diabetic and non-diabetic group were 52% vs 48% and 32% vs 36% respectively. A previous study revealed that, in patients with type 2 diabetes, 31.3% were exposed to sunlight for 30 minutes daily, compared to 34.4% in the non-diabetic group, and 53.1% versus 34.4% exposed to sunlight for 15 minutes.…”

Section: Discussioncontrasting

confidence: 50%

Vitamin D status in Type 2 Diabetes Mellitus in a Tertiary Level Hospital

Saha,

Sarker,

Sarker

et al. 2024

J Rang Med Col.

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Background: There is increasing evidence of a relationship between vitamin D status and type 2 diabetes. Diabetes has also been found to be associated with 25(OH)D (vitamin D) deficiency and the role of vitamin D has recently emerged, especially in preventing cardiovascular diseases and cancer. and insulin resistance. Objective: This study aimed to compare vitamin D deficiency between healthy and Type 2 Diabetes Mellitus (T2DM) patients. Methods: This cross-sectional study was conducted from July 2021 to June 2022 in the Department of Physiology, Rangpur Medical College, Rangpur. For this study, a total number of 100 subjects were selected among them 50 non-diabetic healthy subjects were included as control and 50 Type 2 Diabetes Mellitus patients were included as cases. The subjects of control were selected from the surrounding community of Rangpur district and subjects of cases were selected from Diabetic Association and from Outdoor of Endocrinology Department, Rangpur Medical College and Hospital, Rangpur. For statistical analysis, an independent sample t-test was performed by computer-based software SPSS-23.0 version for windows. Results: The mean vitamin D level was lower in the diabetic patients than in non-diabetic participants (14.1±8.3 ng/ml and 37.3±11.3, p<0.001). Conclusions: Early screening for serum vitamin D level is recommended for T2DM patients. Hence, it is crucial to promptly address any deficiencies in vitamin D levels. J Rang Med Col. March 2024; Vol. 9, No. 1: 77-81

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Section: Discussioncontrasting

confidence: 50%

Vitamin D status in Type 2 Diabetes Mellitus in a Tertiary Level Hospital

Saha,

Sarker,

Sarker

et al. 2024

J Rang Med Col.

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“…Previous studies have reported significant inverse associations of vitamin D with IR (Alemzadeh, et al, 2008) and β-cell dysfunction (Wu, et al, 2009) including cross-sectional study in the current cohort (Kayaniyil, et al, 2010). Only two prospective studies have been conducted to date, both of which reported significant inverse associations of baseline 25(OH)D with IR after 5 and 10 years of follow-up, respectively, in largely white cohorts (Gagnon, et al, 2011). On the other hand, there were relationship between insufficient vitamin D, calcium status and type 2 DM.…”

Section: Resultsmentioning

confidence: 69%

Effects of vitamin D injection and natural products on Blood Glucose Level of Diabetic Patient With Vitamin D Deficiency

M¹

2022

المجلة العلمية لعلوم التربية النوعية

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DM is the 4 th leading cause of global mortality. By the year 2025 the disease incidence is expected to increase to over 380 million, 80% would be in developing countries. It has been proposed that vitamin D deficiency plays an important role in insulin resistance resulting in diabetes. The study was conducted to evaluate the effect of use some foods high in vitamin D content especially (parsley) and drug source of the same vitamin on diabetics and healthy. A selection of the sample is done by analyzing vitamin D in the blood and selecting patients with vitamin D deficiency. 100 people who suffered from type2 diabetes and 50 do not have diabetes and all of them suffer from vitamin D deficiency. Each group was divided into, group I is diabetic patients and vitamin D deficiency and are treated with vitamin D injection only. Group II is diabetics and vitamin D deficiency and are treated with vitamin D plus parsley injections. Group 3 is non-diabetics patients with vitamin D deficiency and are only injecting vitamin D. Group 4 is non-diabetics patients with vitamin D deficiency and need to inject vitamin D plus parsley. The treatment was done for 3 months. The results found that after treatment groups 2 and 4 which received 100 g fresh parsley with ampoules of vit. D were having the highest values statistical significantly (P≤0.05) of serum vit. D. Calcium level of group 4 non-diabetic injected by vit. D and consumed 100g of fresh parsley was the highest value statistical significantly (P≤0.05). HbA1C was high statistical significantly (P≤0.05) in diabetic and non-diabetic patients before treatment. While, after injected by vit. D for groups (1 and 3) and vit. D plus 100g fresh parsley for groups 2 and 4 results showed reduction in serum HbA1C for all groups. The study concluded that there is a relationship between the level of vitamin D and improve the level of blood sugar in patients with diabetes type II. Eating rich vitamin Dcontaining food with fresh parsley gave the best results to type 2 diabetics and vitamin D deficiency patients.

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“…The fact that 10-40% of Americans and 20-60% of Britons have vitamin D levels below 50 nmol/L raises concerns, as stated in a previous study [8]. In Australia, vitamin D deficiency is common in 50% of women and 31% of men despite the country's sunny climate [9].…”

Section: Introductionmentioning

confidence: 91%

Association Between Lower Levels of Vitamin D and Inflammation in the Geriatric Population: A Systematic Review and Meta-Analysis

Alharbi,

Albalawi,

Al Madshush

et al. 2024

Cureus

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There have been suggestions that vitamin D has anti-inflammatory effects; however, the variabilities of vitamin D levels among specific groups of patients and its association with these inflammatory events have not been demonstrated. This study aims to study the association between vitamin D levels and vitamin D deficiency and inflammatory events among the elderly population. PubMed, Web of Science, Scopus, Science Direct, and ClinicalKey were systematically searched in December 2023 to include the relevant data. Comprehensive Meta-Analysis (version 3.0, Biostat, Inc., Englewood, NJ) was the software used for data analyses. A total of 12 studies were included in this analysis with 14,717 elderly patients. There was an overall significant decrease in vitamin D levels in elderly patients with high inflammatory markers compared to controls (Hedges' g = -0.221, 95% CI: -0.268, -0.173, P < 0.001), and event of vitamin D deficiency was found to be 0.321 (95% CI: 0.305, 0.337, P < 0.001). There is a significant decrease in vitamin D levels among the elderly with different inflammatory conditions. Future longitudinal studies and well-designed, large, randomized controlled trials are required to study the association between vitamin D deficiency and the incidence of inflammatory events in this specific group of patients.

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Serum 25-Hydroxyvitamin D Is Associated with Reduced Risk of Metabolic Syndrome at 5 Years: Results from a National, Population-Based Prospective Study (The Australian Diabetes, Obesity and Lifestyle Study — AusDiab)

Cited by 4 publications

References 0 publications

Vitamin D status in Type 2 Diabetes Mellitus in a Tertiary Level Hospital

Vitamin D status in Type 2 Diabetes Mellitus in a Tertiary Level Hospital

Effects of vitamin D injection and natural products on Blood Glucose Level of Diabetic Patient With Vitamin D Deficiency

Association Between Lower Levels of Vitamin D and Inflammation in the Geriatric Population: A Systematic Review and Meta-Analysis

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