Serum 25-hydroxyvitamin D in a West African population of tuberculosis patients and unmatched healthy controls

Wejse, Christian; Olesen, Rikke; Rabna, Paulo; Kæstel, Pernille; Gustafson, Per; Aaby, Péter; Andersen, Paul; Glerup, Henning; Sodemann, Morten

doi:10.1093/ajcn/86.5.1376

Cited by 116 publications

(119 citation statements)

References 30 publications

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“…The need for such trials is pressing, given the very high incidence of TB in HIV-infected adults in Cape Town and the high prevalence of vitamin D deficiency that we report in this group, which is significantly higher than has been reported in tropical Africa (14)(15)(16)(17). To our knowledge, the prevalence of vitamin D deficiency among people of Nguni descent living in Cape Town has not previously been investigated.…”

Section: Discussionmentioning

confidence: 61%

“…The prevalence of profound vitamin D deficiency among TB patients in tropical Africa is much lower than in Europe [reported in 0.3-11.2% of patients with TB in tropical Africa (14)(15)(16)(17) vs. 64-84% of patients with TB in London (18)(19)(20)]. The prevalence of vitamin D deficiency in TB patients with and without HIV infection in subtropical Africa has not previously been reported.…”

Section: Vitamin D Deficiency (Serum 25-hydroxyvitamin D [25(oh)d] <50mentioning

confidence: 96%

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Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa

Martineau

Nhamoyebonde

Oni

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

183

181

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Vitamin D deficiency is associated with susceptibility to tuberculosis (TB) in HIV-uninfected people in Europe, but it is not known whether such an association exists among HIV-infected people in subtropical Africa. We conducted a cross-sectional study to determine whether vitamin D deficiency was associated with susceptibility to active TB in and HIV-infected (n = 174) black Africans in Cape Town, South Africa. We also investigated whether there was evidence of seasonal variation in vitamin D status and TB notifications in this setting over an 8-y period.nmol/L) was present in 232 (62.7%) of 370 participants and was associated with active TB in both HIV-uninfected (odds ratio = 5.2, 95% confidence interval: 2.8-9.7; P < 0.001) and HIV-infected (odds ratio = 5.6, 95% confidence interval: 2.7-11.6; P < 0.001) people. We have previously reported that vitamin D deficiency is associated with susceptibility to TB in London and that this association is modified by polymorphisms in the vitamin D receptor and vitamin D binding protein (8,9). We have also shown that in vivo vitamin D supplementation enhances immunity to mycobacteria both in healthy people (10) and in a genetically defined subgroup of patients with active TB (11). Reports of seasonal variation in the prevalence of vitamin D deficiency (12) and TB incidence (13) in the United Kingdom provide further evidence that low vitamin D status may compromise antimycobacterial immunity in this setting.The prevalence of profound vitamin D deficiency among TB patients in tropical Africa is much lower than in Europe [reported in 0.3-11.2% of patients with TB in tropical Africa (14-17) vs. 64-84% of patients with TB in ]. The prevalence of vitamin D deficiency in TB patients with and without HIV infection in subtropical Africa has not previously been reported. There is particularly good reason to investigate this question in Cape Town, South Africa, because TB incidence in Cape Town is higher than elsewhere in South Africa (21) and the ability of sunlight to synthesize vitamin D is compromised during the winter in Cape Town (latitude 33°south) but not in Johannesburg (latitude 26°south) (22). We therefore conducted an observational study to determine whether vitamin D deficiency is associated with susceptibility to active TB in HIVinfected and HIV-uninfected adults in Cape Town and to investigate whether there is evidence of seasonal variation in vitamin D status and TB notifications in this setting.

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Section: Discussionmentioning

confidence: 61%

Section: Vitamin D Deficiency (Serum 25-hydroxyvitamin D [25(oh)d] <50mentioning

confidence: 96%

Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa

Martineau

Nhamoyebonde

Oni

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

183

181

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“…Mtb is able to evade autophagy by inhibiting fusion of autophagosomes with lysosomes through the ESX‐1 secretion system in primary human DCs (Romagnoli et al ., 2012) and by expressing miR‐30A in THP‐1 macrophages (Chen et al ., 2015). Several studies have linked vitamin D deficiency with an increased risk for susceptibility to active TB (Martineau et al ., 2007; Wejse et al ., 2007; Nnoaham and Clarke, 2008). The active form of vitamin D3 induces autophagy in primary human monocytes and THP‐1 macrophages via the expression of the anti‐microbial peptide cathelicidin, which activates transcription of the autophagy‐related genes encoding Beclin‐1 and ATG5 (Yuk et al ., 2009).…”

Section: Autophagy In the Immune Response To Tbmentioning

confidence: 99%

The innate immune response in human tuberculosis

2015

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Summary M ycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini‐review, we discuss these host–pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome‐wide association studies).

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“…Food intake is usually considered sufficient to represent vitamin D status if exposure to sunlight is ignored [19]. In a study conducted by Lumsden in 2007 shows that there is a weak relationship between dietary intake and serum 25 (OH) D in the TB group.…”

Section: Resultsmentioning

confidence: 99%

Correlation Between the Vitamin D Intake with Clinical Symptoms of Patients Pulmonary Tuberculosis

Suharti¹,

Teda²,

Sulastri³

2017

Proceedings of the 1st Public Health International Conference (PHICo 2016)

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Serum 25-hydroxyvitamin D in a West African population of tuberculosis patients and unmatched healthy controls

Cited by 116 publications

References 30 publications

Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa

Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa

The innate immune response in human tuberculosis

Correlation Between the Vitamin D Intake with Clinical Symptoms of Patients Pulmonary Tuberculosis

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