Serum 25-Hydroxyvitamin D Concentrations Are Associated with Computed Tomography Markers of Subclinical Interstitial Lung Disease among Community-Dwelling Adults in the Multi-Ethnic Study of Atherosclerosis (MESA)

Kim, Samuel M; Zhao, Di; Podolanczuk, Anna J.; Lutsey, Pamela L.; Güallar, Eliseo; Kawut, Steven M.; Barr, R. Graham; Kestenbaum, Bryan; Lederer, David J.; Michos, Erin D.

doi:10.1093/jn/nxy066

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…Low levels of serum 25(OH)VD have been associated with subclinical interstitial lung disease and COPD [10][11][12][13]. Although both 25(OH)VD insufficiency and AATD are extensively linked to decreased lung function, no study has investigated the relationship between 25(OH)VD and AAT levels.…”

Section: Introductionmentioning

confidence: 99%

Reduced 25(OH) Vitamin D Association with Lower Alpha-1-Antitrypsin Blood Levels in Type 2 Diabetic Patients

Lindley

Bhusal

Huning

et al. 2020

Journal of the American College of Nutrition

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Introduction: Reduced circulating levels of 25(OH)VD are associated with an increased incidence of chronic lung diseases. Alpha-1-antitrypsin (AAT) is needed to maintain healthy lung function.Objective: This study examined the hypothesis that circulating levels of AAT are lower in adult type 2 diabetic patients and that a positive association exists between circulating AAT levels and 25(OH)VD levels in these patients. Methods: Fasting blood was obtained after written informed consent from type 2 diabetic patients (n ¼ 80) and normal siblings or volunteers (n ¼ 22) attending clinics at LSUHSC according to the protocol approved by the Institutional Review Board for Human studies. Plasma AAT and 25(OH)VD levels were determined using ELISA kits. HbA 1c levels and chemistry profiles were analyzed at the clinical laboratory of LSUHSC hospital. Results: ATT and 25(OH)VD levels were significantly lower in type 2 diabetic patients compared with those of age-matched healthy controls. There was a significant positive correlation between 25(OH)VD and ATT deficiency. AAT levels showed significant positive correlation with HDL cholesterol levels in type 2 diabetic patients. There was no correlation between AAT levels and those of HbA 1c or with the duration of diabetes of T2D patients. Conclusions: These results suggest that 25(OH)VD deficiency may predispose type 2 diabetic patients to AAT deficiency. Whether reduced levels of circulating AAT indeed contribute to the increased risk for lung dysfunction in subjects with type 2 diabetes needs further investigation.

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Section: Introductionmentioning

confidence: 99%

Reduced 25(OH) Vitamin D Association with Lower Alpha-1-Antitrypsin Blood Levels in Type 2 Diabetic Patients

Lindley

Bhusal

Huning

et al. 2020

Journal of the American College of Nutrition

View full text Add to dashboard Cite

show abstract

“…Rheumatoid arthritis (RA) related autoantibodies and anti-cyclic citrullinated peptide have been associated with ILA among smokers and rheumatoid factor IgA are associated with ILA regardless of smoking history [ 46 ]. Lastly, vitamin D deficiency and the use of hydrophilic HMG-CoA reductase inhibitors (statins) has been linked with ILA, while the omega-3 polyunsaturated fatty acid docosahexaenoic acid is negatively associated with ILA [ 44 , 47 , 48 ].…”

Section: Epidemiological Associations and Parallels With Interstitial Lung Diseasementioning

confidence: 99%

“…Similarly, another RA-related autoantibody, anti-cyclic citrullinated peptide, has been associated with HAA in the subgroup of smokers [ 46 ]. As with ILA, vitamin-D deficiency has been associated with HAA and HAA progression [ 47 ] and HAA have been related to lower HDL-C, ApoA-1, and serum adipokines [ 43 , 80 ]. Amounts of rice in diet, a proposed surrogate for arsenic exposure among urban residents, have been associated with HAA while an association with ILA was not shown [ 81 ].…”

Section: Other Definitions Of Ild Precursorsmentioning

confidence: 99%