Serum 25-hydroxyvitamin D concentrations and mortality in dogs with blastomycosis

Jacobs, Carl; Jaffey, Jared A.; Trepanier, Lauren A.; Pritchard, Jessica C

doi:10.1016/j.tvjl.2021.105707

Cited by 3 publications

(8 citation statements)

References 36 publications

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“…While similar associations were not identified in the single study that investigated vitamin D in humans with coccidioidomycosis, the small study sample could have resulted in limited genotype variability as well as type II error 19 . Vitamin D is a relevant biomarker in dogs with a wide array of infections but has yet to be investigated in dogs with coccidioidomycosis 20‐26 . C‐reactive protein (CRP) is a positive acute phase protein produced as a reaction to systemic inflammation.…”

Section: Introductionmentioning

confidence: 99%

“… 19 Vitamin D is a relevant biomarker in dogs with a wide array of infections but has yet to be investigated in dogs with coccidioidomycosis. 20 , 21 , 22 , 23 , 24 , 25 , 26 C‐reactive protein (CRP) is a positive acute phase protein produced as a reaction to systemic inflammation. Systemic inflammation decreases serum 25(OH)D concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease

Jaffey

Kreisler

Shubitz

et al. 2023

Veterinary Internal Medicne

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Background Clinicopathologic variables predictive of disseminated coccidioidomycosis are known in humans but have not been explored in dogs. Serum 25‐hydroxyvitamin (OH)D correlates with severity of disease of various etiologies in dogs but its role in coccidioidomycosis is unknown. Objective Determine whether serum 25(OH)D concentrations are different in dogs with coccidioidomycosis compared with healthy controls and if clinicopathologic variables are associated with extent of disease. Animals Thirty‐five dogs with coccidioidomycosis (pulmonary, n = 13; disseminated, n = 15; uncharacterized, n = 7), and 25 healthy control dogs. Methods Prospective cohort study. Serum 25(OH)D and C‐reactive protein (CRP) concentrations were measured with modified‐HPLC and a commercial ELISA kit, respectively. Results There was no difference in 25(OH)D concentrations between dogs with coccidioidomycosis (median, interquartile range [IQR]; 31.9 ng/mL, 23.3‐49.2) and controls (29.5 ng/mL, 25.6‐40.8, P = .73). Serum 25(OH)D concentration was lower in dogs with coccidioidomycosis and IgG titers ≥1:32 than dogs with titers below this cut‐off (P = .02). Dogs with IgG titers ≥1:32 were more likely to have disseminated disease (OR, 7.5; 95% CI: 1.1‐68; P = .03). Serum CRP concentrations were higher in dogs with IgG titers ≥1:16 (median, IQR; 4474.8 ng/mL, 2885.8‐8236.1) than in those below this cut‐off (151.2 ng/mL, 30.4‐2907.3; P = .02). There was a significant inverse association between serum 25(OH)D and CRP at 25(OH)D concentrations ≤33 ng/mL. Conclusion and Clinical Importance Serum 25(OH)D concentration was lower for dogs with IgG titers ≥1:32, indicating a potential association between semi‐quantitative titers and 25(OH)D concentrations in dogs with coccidioidomycosis. IgG titers ≥1:32 yielded higher odds of disseminated disease, but was inadequate as a standalone test to determine form of disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease

Jaffey

Kreisler

Shubitz

et al. 2023

Veterinary Internal Medicne

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“…Serum 25(OH)D concentration was lower in dogs with histoplasmosis, which supports our hypothesis and is in agreement with associations identified between 25(OH)D and various infections in humans and dogs. 20 , 21 , 22 , 23 , 24 , 25 , 26 Serum 25(OH)D has not been critically evaluated in humans or other species with histoplasmosis. Importantly, this observational study could not determine if the decreased serum 25(OH)D concentration contributed to the development of histoplasmosis, was a sequela of the infection, or a combination thereof.…”

Section: Discussionmentioning

confidence: 99%

“… 20 , 21 , 22 , 23 Studies in dogs have shown associations between low serum 25‐hydroxyvitamin D (25(OH)D), the main circulating vitamin D analog, and several different infections, although causality remains unclear. 24 , 25 , 26 , 27 , 28 , 29 The relationship between serum 25(OH)D and histoplasmosis is unknown but might have value as a biomarker for prognosis and treatment monitoring.…”

Section: Introductionmentioning

confidence: 99%

“…It is through these immunologic functions that vitamin D is speculated to have a protective role in several infections in humans such as Mycobacterium tuberculosis , blastomycosis, community‐acquired pneumonia, and acute respiratory tract infections 20‐23 . Studies in dogs have shown associations between low serum 25‐hydroxyvitamin D (25(OH)D), the main circulating vitamin D analog, and several different infections, although causality remains unclear 24‐29 . The relationship between serum 25(OH)D and histoplasmosis is unknown but might have value as a biomarker for prognosis and treatment monitoring.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of serum 25‐hydroxyvitamin D, C‐reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis

Hernandez

Jaffey

Cohn

et al. 2023

Veterinary Internal Medicne

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Background Serum 25‐hydroxyvitamin (OH)D, C‐reactive protein (CRP), and haptoglobin are useful biomarkers in various infectious diseases and inflammatory disorders in dogs, but their utility in histoplasmosis is unknown. Objective Determine if serum 25(OH)D, CRP, and haptoglobin concentrations are different in dogs with histoplasmosis compared to healthy controls and whether serum globulin, albumin, CRP, or haptoglobin are associated with 25(OH)D concentration. Animals Twenty‐two client‐owned dogs (histoplasmosis, n = 12; controls, n = 10). Methods Prospective case‐control study. Dogs with histoplasmosis were categorized as pulmonary, disseminated, or gastrointestinal (GI) tract. Serum 25(OH)D was measured using modified high‐performance liquid chromatography (HPLC). Serum CRP and haptoglobin were measured with ELISA assays. Results Dogs with histoplasmosis were grouped as disseminated (n = 8) and GI tract (n = 4). No dogs had pulmonary tract involvement alone. Dogs with histoplasmosis (median, interquartile range [IQR]; 11.6 ng/mL, 16.8) had lower serum 25(OH)D concentrations than controls (35.7 ng/mL, 17.6; P < .001). Serum CRP and haptoglobin concentrations were higher in dogs with histoplasmosis (CRP: median, IQR; 63.5 mg/L, 37.1 and haptoglobin: 459.7 mg/dL, 419.6) than controls (CRP: 1.9 mg/L, 2; P < .001 and haptoglobin: 85.5 mg/dL, 106.7; P = .003). Serum 25(OH)D concentration was positively associated with fold change in serum albumin concentration ( ρ = 0.77; P < .001), and negatively associated with fold change in serum globulin ( ρ = −0.61; P = .003) and CRP concentrations ( ρ = −0.56; P = .01). Conclusion and Clinical Importance Assay of serum 25(OH)D, CRP, and haptoglobin could have clinical value in dogs with histoplasmosis.

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Serum vitamin D metabolite and acute-phase protein concentrations are frequently abnormal in a cohort of hospitalized dogs and cats

Rose,

Jaffey,

Cammarano

et al. 2024

javma

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OBJECTIVE To determine whether serum 25-hydroxyvitamin D (25[OH]D) and 1,25-dihydroxyvitamin D (1,25[OH]2D) concentrations are associated with survival and negatively correlate with acute-phase protein (APP) concentrations in ill dogs and cats admitted to nursing care units. ANIMALS Client-owned dogs (n = 79) and cats (16) admitted to 2 academic veterinary hospital nursing care units. METHODS A prospective cohort study was conducted between August 12, 2019, and October 26, 2021. A diagnostic laboratory measured 25(OH)D, 1,25(OH)2D, and haptoglobin (HPT) in dogs and cats; C-reactive protein (CRP) in dogs; and serum amyloid A (SAA) in cats. Serum was collected within 12 hours of admission. Illness severity (acute patient physiologic and laboratory evaluation [APPLEfast]) scores and survival data were recorded. RESULTS Serum 25(OH)D concentrations were in the deficient range for 22 of 79 dogs and 2 of 16 cats. There were no associations between serum analyte concentrations (25[OH]D, 1,25[OH]2D, and APP) or APPLEfast score and survival in dogs or cats. In dogs, HPT was negatively correlated with 25(OH)D (P = .002; r = –0.34) and 1,25(OH)2D (P = .012; r = –0.28), while CRP was positively correlated with HPT (P = .001; r = 0.32) and APPLEfast score (P = .014; r = 0.16). In cats, 1,25(OH)2D was negatively correlated with APPLEfast scores (P = .055; r = –0.49) and SAA was positively correlated with HPT (P = .002; r = 0.73). CLINICAL RELEVANCE Serum 25(OH)D or 1,25(OH)2D was not associated with survival in our hospitalized patient population. Relationships between APP and serum vitamin D metabolites with APPLEfast scores in cats warrant further investigation as illness severity biomarkers.

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Serum 25-hydroxyvitamin D concentrations and mortality in dogs with blastomycosis

Cited by 3 publications

References 36 publications

Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease

Serum 25‐hydroxyvitamin D concentrations in dogs with coccidioidomycosis and variables associated with extent of clinically evident disease

Evaluation of serum 25‐hydroxyvitamin D, C‐reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis

Serum vitamin D metabolite and acute-phase protein concentrations are frequently abnormal in a cohort of hospitalized dogs and cats

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