Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity

Abstract

Background An inverse correlation between serum 25-hydroxyvitamin D concentration and atopic dermatitis (AD) severity has been suggested. Objective To determine if a statistically significant relationship exists between serum 25-hydroxyvitamin D concentration and AD severity. Methods A cross-sectional study was conducted of patients with AD aged 1–18 years. An objective Severity Scoring of Atopic Dermatitis (SCORAD) and a serum 25-hydroxyvitamin D concentration were measured for each subject. Statistical analysis was performed using appropriate univariate tests and multivariable models. Results Ninety-four of 97 enrolled subjects were included in the analysis. Vitamin D deficiency (25-hydroxyvitamin D <20ng/ml) was present in 37 (39%), insufficiency (25-hydroxyvitamin D 21–29 ng/mL) in 33 (35%), and sufficiency (25-hydroxyvitamin D ≥30 ng/ml) in 24 (26%). The correlation between 25-hydroxyvitamin D concentration and SCORAD was not significant (r=−0.001, p=0.99). A multivariate model showed that a lower serum 25-hydroxyvitamin D concentration was significantly associated with age ≥3-years (p<0.0001), black race (p<0.0001), and winter season (p=0.0084). Limitations Limitations of this study include the inability to control for natural sunlight exposure, vitamin D intake and AD treatment, and that only a single time point was captured. Conclusions Serum 25-hydroxyvitamin D concentration is not significantly correlated with AD severity in our pediatric population.

Evaluation of 25-hydroxy vitamin D and specific immunoglobulin E to Staphylococcus aureus in patients with atopic dermatitis and their correlation with the disease severity

“…This is in agreement with the study by other authors [12][13][14][15], who linked vitamin D deficiency to prevalence of AD and other allergic diseases.…”

“…In addition, we found that 66.7% of the AD patients had insufficient or deficient vitamin D; this is in accordance with the results of other studies [13][14][15] but with different percentages ranging from 61 to 82.5%. This variation in the percentages of patients with insufficient or deficient vitamin D may be due to the great variation in the clinical severity of AD in each study.…”

“…However, Chiu et al [14] found significantly lower serum 25(OH)D concentrations to be associated with an age of 3 years or above. Lack of significant correlation between serum 25(OH)D levels and age of the patients in the present study may be due to limited number of patients in a wide age range (1-14 years).…”

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

“…Samochocki et al [32] found that the mean serum concentration of 25(OH)D3 was not significantly different between patients with AD and control subjects. Studies by Chiu et al [33] and Han et al[34] showed that although VD levels were lower in AD patients than in HCs, there was no correlation between VD levels and AD. A few plausible explanations have been suggested to explain these contrary results about the relationship between VD and AD.…”

The Role of Vitamin D in Atopic Dermatitis

“…26 In contrast to the already mentioned results, some studies did not find any relationship between vitamin D concentration and AD severity. 23,27 In a cross-sectional study conducted in 97 children with AD, Chiu et al 27 found no correlation between levels of vitamin D and SCORAD (P = 0.99). More recently, Hata et al, 23 in a randomized, placebo-controlled, double-blind study conducted on 76 atopic, nonatopic, and psoriatic adult patients, also reported no vitamin D influence on the AD severity both before and after supplementation.…”