Serum 1,5-Anhydroglucitol to Glycated Albumin Ratio Can Help Early Distinguish Fulminant Type 1 Diabetes Mellitus from Newly Onset Type 1A Diabetes Mellitus

Ying, Lingwen; Ma, Xiaojing; Shen, Yun; Lu, Jingyi; Lü, Wei; Zhu, Wei; Wang, Yufei; Bao, Yuqian; Zhou, Jian

doi:10.1155/2020/1243630

Cited by 7 publications

(9 citation statements)

References 25 publications

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“…DKA, which occurs during pregnancy, does great harm to the mother and fetus and can endanger their lives [ 3 , 4 ]. Metabolic changes that occur during pregnancy can make pregnant diabetics more inclined to DKA [ 5 ]. At present, prenatal diabetes screening, regular prenatal examination, and positive and correct treatment have greatly improved the incidence and prognosis of ketoacidosis during pregnancy, and the maternal mortality has decreased significantly [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Continuous Subcutaneous Injection of Insulin Analogues in Pregnant Women with Diabetes Mellitus Complicated with Ketoacidosis

Pan

Wang

Zhao

et al. 2021

Journal of Healthcare Engineering

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Objective. To investigate the clinical effect of continuous subcutaneous injection of insulin analogues in pregnant women with diabetes mellitus complicated with ketoacidosis. Methods. A total of 92 pregnant patients with diabetes mellitus complicated with ketoacidosis from June 2014 to January 2021 were selected. All patients were randomly divided into an observation group and control group according to the method of random number. The control group received intravenous infusion of insulin, and the observation group received continuous subcutaneous infusion of quick-acting insulin analogues. The clinical effects of the two groups were observed. Results. The time needed to control blood glucose <13.8 mmol/L, the amount of insulin needed to control blood glucose <13.8 mmol/L, the time needed to correct DKA, and the amount of insulin needed to correct DKA in the observation group were significantly less than those in the control group ( P < 0.05 ). Compared with the control group, the average occurrence times of hypoglycemia, the length of stay, the total amount of insulin in hospital, and the total amount of insulin used during pregnancy in the observation group were significantly less than those in the control group ( P < 0.05 ). The values of SCr, CRP, BUN, arterial blood gas pH, and adiponectin in the two groups were significantly improved as compared with those before treatment, and the improvement in the observation group was significantly better than that in the control group ( P < 0.05 ). After treatment, the fasting blood glucose, 2-hour postprandial blood glucose, carbon dioxide binding capacity, and glycosylated hemoglobin in the experimental group were significantly better than those in the routine group, and the difference was statistically significant ( P < 0.05 ). Conclusion. Continuous subcutaneous injection of insulin analogues is effective in the treatment of diabetic patients with ketoacidosis, which can effectively improve blood glucose, carbon dioxide binding capacity, and glycosylated hemoglobin and accelerate the negative conversion of urinary ketone body. It is worth popularizing to reduce the occurrence of hypoglycemia and the dose of insulin and shorten the time of hospitalization.

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Section: Introductionmentioning

confidence: 99%

Effect of Continuous Subcutaneous Injection of Insulin Analogues in Pregnant Women with Diabetes Mellitus Complicated with Ketoacidosis

Pan

Wang

Zhao

et al. 2021

Journal of Healthcare Engineering

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“…Our results indicate FI (PG/HbA1c ≥ 4.39 mmol/L/%, K + /HbA1c ≥ 0.85 mmol/L/%, Na + *HbA1c ≤ 923.65 mmol*%/L) can be adopted as a new set of biomedical indexes in diagnosing FT1D. In recent ndings on the diagnosis of FT1D, GA 20 , 1,5-anhydroglucitol (1,5-AG)/GA 21 , the GA/HbA1c ratio 22 and the PG/HbA1c ratio 23 were used for screening FT1D. The GA/HbA1c ratio and PG/HbA1c ratio are both FI.…”

Section: Discussionmentioning

confidence: 78%

“…In the differential diagnosis between FT1D and T1ADM, ROC analysis showed that the optimum cut-off value for GA was 33.5% with a sensitivity and speci city of 97.4% and 96.8%, respectively 20 . And GA and 1,5-AG are indicators that re ect short-term glucose levels, 1,5-AG/GA can help facilitate the early differential diagnosis of FT1DM and T1ADM when HbA1c < 8:7%, with an optimal cut-off point of 0.3 21 . FI (GA/HbA1c) for FT1D patients has already been reported to be higher than for patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

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The fulminant index: A method of rapidly differentiating fulminant type 1 diabetes from diabetic ketoacidosis

Qiu

Chen

et al. 2021

Diabetes Metabolism Res

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Department of Endocrinology,the ninth a liated hospital of guangxi medical university Xia Li department of metabolism and endocrinology,th second xiangya hospital,central south university Wen Chen department of endocrinology,the ninth a liated hospital of guangxi medical university Xiaoxi Ma department of metabolism and endocrinology, the second xiangya medical hospital, central south university Zhiguo Xie department of metabolism and endocrinology,the second xiangya hospital,central south university Gan Huang department of metabolism and endocrinology,the second xiangya hospital,central south university Shuoming Luo department of metabolism and endocrinology, the second xiangya hospital,central south university Zhiguang Zhou ( 

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“…Both endogenous or exogenous insulin is capable of effecting serum electrolyte levels, especially K + . 21 , the GA/HbA1c ratio 22 and the PG/HbA1c ratio 23 were used for screening FT1D. The GA/HbA1c ratio and PG/HbA1c ratio are both FI.…”

Section: Discussionmentioning

confidence: 99%

The Fulminant Index: A Method of Rapidly Differentiating Fulminant Type 1 Diabetes From Diabetic Ketoacidosis

Qiu

Chen³

et al. 2020

Preprint

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Objectives Fulminant type 1 diabetes (FT1D) usually presents with diabetes ketoacidosis(DKA) at the disease onset. Early identification of FT1D is crucial. This study was aimed at investigating whether the fulminant index (FI), including plasma glucose (PG) to glycated hemoglobin(HbA1c) ratio (PG/HbA1c), serum potassiumion (K+) to HbA1c ratio (K+/HbA1c), and serum sodiumion (Na+) multiplied by HbA1c (Na+*HbA1c), is a suitable indicator for early FT1D identification.Methods A total of 76 subjects were enrolled, including 40 FT1D patients and 36 non-FT1D patients with DKA. We utilized receiver operating characteristic (ROC) curve analysis to determine the FI cut-off values between FT1D and non-FT1D groups.Results ROC curve analyses showed that the maximum Youden’s index for PG/HbA1c bonding to a cut-off value of 4.39, with the sensitivity of 75.0% and specificity of 77.8% in identifying FT1D from DKA. And optimal K+/HbA1c cut-off value was 0.85 with the sensitivity of 77.5% and specificity of 94.4%. For Na*HbA1c, the best cut-off value was 923.65, and its sensitivity and specificity were 85% and 69.4%, respectively.Conclusions These results suggested FI could work as a suitable and convenient indicator for differentiating FT1D from initial DKA patients, among which the FI (K+/HbA1c) presented the best .

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Serum 1,5-Anhydroglucitol to Glycated Albumin Ratio Can Help Early Distinguish Fulminant Type 1 Diabetes Mellitus from Newly Onset Type 1A Diabetes Mellitus

Cited by 7 publications

References 25 publications

Effect of Continuous Subcutaneous Injection of Insulin Analogues in Pregnant Women with Diabetes Mellitus Complicated with Ketoacidosis

Effect of Continuous Subcutaneous Injection of Insulin Analogues in Pregnant Women with Diabetes Mellitus Complicated with Ketoacidosis

The fulminant index: A method of rapidly differentiating fulminant type 1 diabetes from diabetic ketoacidosis

The Fulminant Index: A Method of Rapidly Differentiating Fulminant Type 1 Diabetes From Diabetic Ketoacidosis

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