Serum 1,5-anhydroglucitol levels slightly increase rather than decrease after a glucose load in subjects with different glucose tolerance status

Su, Hang; Ma, Xiaojing; Yin, Jun; Wang, Yufei; He, Xingxing; Bao, Yuqian; Zhou, Jian; Jia, Weiping

doi:10.1007/s00592-017-0968-z

Cited by 13 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A Japanese study [ 6 ] of 77 healthy men showed that there were significant increases at 90, 120, and 180 min after the OGTT. Our previous study involving 681 with differing degrees of glucose tolerance suggested that serum 1,5-AG levels slightly increased rather than decreased after a glucose load [ 8 ], which were similar to the results of the present study. A drastic efflux of 1,5-AG into the blood that was induced by acute hyperglycemia may provide a partial explanation to some extent [ 29 , 30 ].…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Comparative Agreement Analysis of Differences in 1,5-Anhydroglucitol, Glycated Albumin, and Glycated Hemoglobin A1c Levels between Fasting and Postprandial States in Steamed Bread Meal Test

Wang

et al. 2017

International Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Background Our previous study indicated that serum 1,5-anhydroglucitol (1,5-AG) levels slightly increased after a glucose load; therefore, this study was conducted to explore short-term changes in 1,5-AG levels after a steamed bread meal test (SBMT) and compare the agreement of 1,5-AG, glycated albumin (GA), and glycated hemoglobin A1c (HbA1c) levels between fasting and postprandial states after an SBMT. Methods 104 participants were recruited and underwent a 100 g SBMT. Fasting, 30 min, and 120 min of 1,5-AG, GA, and HbA1c were measured. Results Levels of 1,5-AG slightly increased from 30 to 120 min after an SBMT (P < 0.01), and HbA1c and GA levels showed stability at 30 and 120 min. The Passing-Bablok regression linear equation showed that postprandial 1,5-AG, GA, and HbA1c levels were well fitted (all P > 0.05), and Bland-Altman difference plot showed that 100% of data points for HbA1c30 and HbA1c120 fell within the limits of agreement; 94.2%, 96.2%, 95.2%, and 95.2% of data points for 1,5-AG30, 1,5-AG120, GA30, and GA120 fell within the limits of agreement, respectively. Conclusion Agreement analyses indicated good stability of 1,5-AG, GA, and HbA1c levels after the SBMT. HbA1c had an optimal stability, which was superior to that of GA or 1,5-AG.

show abstract

Section: Discussionsupporting

confidence: 91%

“…Despite this, only a few studies have attempted to validate agreement between baseline and postload levels of these 3 indicators [ 5 – 7 ]. Our previous study indicated that serum 1,5-AG levels slightly increased after a glucose load [ 8 ]. Nearly all consistency researches are conducted with the oral glucose tolerance test (OGTT).…”

Section: Introductionmentioning

confidence: 99%

Comparative Agreement Analysis of Differences in 1,5-Anhydroglucitol, Glycated Albumin, and Glycated Hemoglobin A1c Levels between Fasting and Postprandial States in Steamed Bread Meal Test

Wang

et al. 2017

International Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…A 75-g OGTT was administered to each patient to assay the 2hPG. Standard laboratory measurements were performed 22 . Serum 1,5-AG levels were measured by an enzymatic method (GlycoMark; GlycoMark Inc., New York, NY, USA) on a 7600 autoanalyzer (Hitachi, Tokyo, Japan) with inter- and intra- assay coefficients of variation (CVs) of <3.5% and <2.5%, respectively.…”

Section: Methodsmentioning

confidence: 99%

Serum 1,5-anhydroglucitol when used with fasting plasma glucose improves the efficiency of diabetes screening in a Chinese population

Ying

et al. 2017

Sci Rep

Self Cite

View full text Add to dashboard Cite

Serum 1,5-anhydroglucitol (1,5-AG) levels can not only accurately reflect the mean blood glucose over the previous 1–2 weeks in diabetic patients but also offers the advantage of representing postprandial glucose. To evaluate the clinical significance of 1,5-AG in diabetes detection, especially when used in combination with fasting plasma glucose (FPG), a total of 3098 participants at high risk for diabetes (1467 men, 1631 women) were enrolled. A total of 1471 (47.5%) participants were diagnosed with diabetes, and the mean 1,5-AG level in the diabetic group was significantly lower than that in non-diabetic group [12.5 (7.8–17.5) μg/mL vs. 20.5 (15.3–26.4) μg/mL, P < 0.001]. The optimal cut-off point was 15.9 μg/mL, for which the sensitivity, specificity, and area under the curve (AUC) were 69.2%, 72.3%, and 0.781, respectively. For the combination of FPG and 1,5-AG, the sensitivity, specificity, and AUC improved to 82.5%, 83.5%, and 0.912, respectively. This method helped 75.8% of the participants avoid an oral glucose tolerance test (OGTT), reducing the need to carry out the OGTT by 43.9% compared to the use of the FPG criterion only. In conclusion, the addition of FPG to serum 1,5-AG improves the efficiency of diabetes screening in the Chinese population.

show abstract

“…Glycated hemoglobin A1c (HbA1c) is more easily used as an indicator to detect changes in plasma glucose throughout pregnancy; however, HbA1c is not a substitute for OGTT diagnosis now 12. In recent years, serum 1,5-anhydroglucitol (1,5-AG) has been considered to be a useful glycemic marker for diabetes control and may be a new indicator for detecting GDM 13–15. Serum 1,5-AG reflects shorter-term changes in plasma glucose in patients compared with HbA1c 16.…”

Section: Introductionmentioning

confidence: 99%

Maternal glycemic parameters and adverse pregnancy outcomes among high-risk pregnant women

Zheng

Shen

Jiang

et al. 2019

BMJ Open Diab Res Care

Self Cite

View full text Add to dashboard Cite

ObjectiveWe aimed to investigate the association between maternal glycemic parameters and adverse pregnancy outcomes among high-risk pregnant women.Research design and methodsA total of 1976 high-risk pregnant women were enrolled between 2015 and 2017. All participants received a 75 g oral glucose tolerance test during the 24–30 gestational weeks and complete birth and delivery information was collected. Adverse pregnancy outcomes were defined as premature birth, birth weight >90th percentile, primary cesarean section, and pre-eclampsia. Logistic regression models were used to assess the association between five maternal glycemic parameters during pregnancy (fasting glucose, 1-hour glucose, 2-hour glucose, HbA1c, and serum 1,5-anhydroglucitol (1,5-AG)) and adverse pregnancy outcomes.ResultsOf 1976 participants, 498 were diagnosed with gestational diabetes. The multivariable-adjusted ORs of adverse pregnancy outcomes for each one unit increase (1 mmol/L, 1%, or 1 µg/mL) were 2.32 (95% CI 1.85 to 2.92) for fasting glucose, 1.07 (95% CI 1.01 to 1.15) for 1-hour glucose, 1.03 (95% CI 0.96 to 1.10) for 2-hour glucose, 1.77 (95% CI 1.34 to 2.33) for HbA1c, and 0.96 (95% CI 0.94 to 0.98) for 1,5-AG, respectively. When all five glycemic parameters were simultaneously entered into the multivariable-adjusted model, only fasting glucose was significantly associated with total and individual adverse pregnancy outcomes. Receiver operating characteristic curve showed that fasting glucose plus any one of other four glycemic parameters had significantly enhanced the sensitivity of detecting adverse pregnancy outcomes.ConclusionsFasting glucose at 24–30 gestational weeks was strongly associated with adverse pregnancy outcomes. Fasting glucose combined with one additional glycemic measurement showed non-inferiority indicating that post-load glycemic measurement was not necessary in detecting adverse pregnancy outcomes among high-risk pregnant women.

show abstract

Serum 1,5-anhydroglucitol levels slightly increase rather than decrease after a glucose load in subjects with different glucose tolerance status

Cited by 13 publications

References 25 publications

Comparative Agreement Analysis of Differences in 1,5-Anhydroglucitol, Glycated Albumin, and Glycated Hemoglobin A1c Levels between Fasting and Postprandial States in Steamed Bread Meal Test

Comparative Agreement Analysis of Differences in 1,5-Anhydroglucitol, Glycated Albumin, and Glycated Hemoglobin A1c Levels between Fasting and Postprandial States in Steamed Bread Meal Test

Serum 1,5-anhydroglucitol when used with fasting plasma glucose improves the efficiency of diabetes screening in a Chinese population

Maternal glycemic parameters and adverse pregnancy outcomes among high-risk pregnant women

Contact Info

Product

Resources

About