Serum 1, 25-Hydroxyvitamin D: A Useful Index of Cognitive and Physical Functional Impairment in Healthy Older Adults in Japan: A Pilot Study

Hasegawa, Noboru; Mochizuki, Miyako; Kato, Masaaki; Yamada, Takako; Shimizu, Nobuko; Torii, Akihisa

doi:10.4236/health.2016.815163

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Vitamin D3 supplementation improves muscle function and physical performance in the elderly population using 4 meter gait speed test (4 MGS) [11]. In our latest study, a significant positive correlation was found between urinary 25 OHD/creatinine and MMSE or Japanese version of the MoCA (MoCA-J), and a significant negative correlation between serum 1,25 OHD and TUG or 4 MGS [12]. Other studies, however, have not found an association between vitamin D and physical performance [13] [14] [15] [16] [17].…”

Section: Introductionmentioning

confidence: 79%

Vitamin D3 Supplementation Improved Physical Performance in Healthy Older Adults in Japan: A Pilot Study

Hasegawa¹,

Mochizuki²,

Kato³

et al. 2018

Health

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Japan has the highest proportion of older adults and so-called "Super-aged society" in the world. These results suggested that the prevalence of both cognitive and physical functional impairment increases with age. Therefore, the present study was designed to investigate the effect of vitamin D3 supplementation in cognitive and physical functional impairment in healthy older adults in Japan. We enrolled 7 Japanese male (age: 76.0 ± 8.7) and 5 female (age: 78.3 ± 9.3) in this study. The physical function of even a person getting on a wheelchair could be tested in all subjects. Treatment group (n = 7) consisted of a 500 IU/day vitamin D3 corresponding to twice of daily requirement for 6 months. Blood was collected by venipuncture and the serum 25-hydroxy vitamin D ( 25OHD), 1,25-hydroxy vitamin D (1,25 OHD), Ca and PTH concentration were measured. The Mini-Mental State Examination and the Montreal Cognitive Assessment-Japanese version were used for the cognitive function test. Physical function was measured objectively using the Timed Up and Go (TUG), 4-mgait speed test (4 MGS), 5-repetition sit-to-stand (5 STS), 30-second chair stand test (CS-30) and measurement of upper grip strength. Our results show that a 6-month intake of vitamin D3 increased serum 25 OHD within the insufficiency and sufficiency levels without changing 1,25 OHD, Ca and PTH concentration. And it significantly decreased 4 MGS without changing TUG, 5 STS, CS-30, upper grip strength and cognitive function. Serum 25 OHD cut-off values for skeletal muscle index, grip strength and 4 MGS in diagnosis of sarcopenia are 18.6 -23.4 ng/mL. These findings suggest that serum 25 OHD levels (23.4 ng/mL

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Section: Introductionmentioning

confidence: 79%

Vitamin D3 Supplementation Improved Physical Performance in Healthy Older Adults in Japan: A Pilot Study

Hasegawa¹,

Mochizuki²,

Kato³

et al. 2018

Health

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“…En lo referente a los niveles de vitamina D y su relación con las caídas, aunque no se encontró significancia estadística, es pertinente destacar que esta vitamina contribuye a mejorar la función física como lo expresaron en su estudio Hasegawa et al 27 . De igual manera, Bischoff-Ferrari et al 28 afirmaron que un nivel adecuado de vitamina D se asocia con una mejoría en la función muscular que conlleva a disminuir el riesgo de caídas, unido al efecto protector sobre las fracturas por el beneficio de la vitamina D en la homeostasis del calcio, asimismo, Bischoff-Ferrari, et al 29 destacaron que la debilidad muscular proximal es una característica clínica importante de la deficiencia de vitamina D y los niveles de 25OHD se asocian con la función de las extremidades inferiores, mejorando progresivamente hasta 40 ng/ml.…”

Section: Discussionunclassified

Prevalencia de caídas y factores de riesgo intrínsecos en personas adultas mayores. Barranquilla (Atlántico), Colombia

Suárez-Landazábal¹,

Parody-Muñoz²

2022

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Introducción: el riesgo de caídas es de carácter multifactorial, ya sea debido a factores extrínsecos o intrínsecos. Las caídas se consideran el principal mecanismo de lesión no intencional en los mayores. Objetivo: determinar la prevalencia de caídas y factores de riesgo intrínsecos en personas adultas mayores de la ciudad de Barranquilla (Colombia). Materiales y métodos: estudio descriptivo correlacional, realizado en 98 adultos mayores, tanto institucionalizados como en comunidad, residentes en Barranquilla (Atlántico), Colombia. Se aplicó una encuesta sobre factores de riesgo intrínsecos; el riesgo de caída se midió con la escala de Berg y se establecieron niveles de Vitamina D en sangre. Resultados: el promedio de edad fue de 75 años, con edades más avanzadas en población institucionalizada. La prevalencia general de caídas fue de 49 % en el último año. El 68,8 % de la población que presentó caídas fueron mujeres, con mayor proporción de caídas en los residentes en hogares geriátricos (52,1 %). Las mujeres provenientes de la comunidad se cayeron más que los hombres (91,3 %) lo cual muestra significancia estadística frente a las caídas (p = 0,002). El consumo de antihipertensivos fue el de mayor proporción (92 %), lo cual demuestra que es estadísticamente significativa para la población institucionalizada (p = 0,0224). El riesgo de caída alto y moderado fue mayor en la población institucionalizada (32 %). El 79,2 % de los individuos que presentaron caídas presentó niveles de vitamina D insuficientes. Conclusión: la población adulta mayor presenta una alta prevalencia de caídas, especialmente las mujeres y la población institucionalizada en centros geriátricos. Los hechos que presentaron significancia estadística fueron ser mujer y provenir de la comunidad, junto con el consumo de antihipertensivos en población institucionalizada.

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“…Vitamin D supplementation caused significant improvement in cognitive performance assessed by MMSE score in Alzheimer's disease [12][13][14]. In our latest study, a significant positive correlation was found between urinary 25-hydroxy vitamin D (25OHD)/creatinine and MMSE or the Montreal Cognitive Assessment-Japanese version the Montreal Cognitive Assessment-Japanese version (MoCA-J) [15].…”

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Vitamin D3 Supplementation Improved Cognitive Function in Diabetic Elderly Patients with Good Glycemic Control in Japan: A Pilot Study

Hasegawa¹,

Mochizuki²,

Yamada³

2019

Int J Nurs Clin Pract

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Background:We studied the effects of vitamin D3 supplementation on serum levels of glycosylated hemoglobin, 25-hydroxyvitamin D and 1, 25-hydroxyvitamin D, and on cognitive function in elderly diabetic patients.Methods: We enrolled 6 male and 9 female Japanese patients (age: 74.4 ± 6.2) with controlled diabetes mellitus who attended an outpatient clinic. The serum glycosylated hemoglobin, 25-hydroxy vitamin D, and 1, 25-hydroxy vitamin D concentrations were measured prior to supplementation and after 3, 9 and 12 months of supplementation with vitamin D3 (500 IU/day of vitamin D3, corresponding to twice the daily requirement). The Montreal Cognitive Assessment-Japanese version was used for the cognitive function test. Data were analyzed using a two-way ANOVA or the Friedman test followed by a Bartlett analysis for homoscedasticity. Results:The results showed that before vitamin D3 supplementation 25-hydroxy vitamin D level was < 20ng/ mL (deficient) in all patients except one (insufficient). Our results show that individual 25-hydroxy vitamin D levels vary significantly from each other and by supplementation duration. The vitamin D deficient group decreased from 14 to 8 patients (5: became insufficient, 1: became sufficient) and the insufficient group decreased from 1 to 0patients after 9 months. The 1, 25-hydroxyvitamin D and glycosylated hemoglobin levels did not vary significantly with duration of supplementation. The Montreal Cognitive Assessment-Japanese version scores did not vary significantly from each other or by supplementation duration. However, we observed increased Montreal Cognitive Assessment-Japanese version scores after supplementation in 60% of the patients. Conclusion:These findings show that vitamin D supplementation is associated with improved serum vitamin D levels and might improve cognitive function.

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Serum 1, 25-Hydroxyvitamin D: A Useful Index of Cognitive and Physical Functional Impairment in Healthy Older Adults in Japan: A Pilot Study

Cited by 3 publications

References 18 publications

Vitamin D3 Supplementation Improved Physical Performance in Healthy Older Adults in Japan: A Pilot Study

Vitamin D3 Supplementation Improved Physical Performance in Healthy Older Adults in Japan: A Pilot Study

Prevalencia de caídas y factores de riesgo intrínsecos en personas adultas mayores. Barranquilla (Atlántico), Colombia

Vitamin D3 Supplementation Improved Cognitive Function in Diabetic Elderly Patients with Good Glycemic Control in Japan: A Pilot Study

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