Sertraline in the treatment of premature ejaculation: A double-blind placebo controlled study

Biri, Hasan; İsen, Kenan; Sınık, Zafer; Onaran, Metin; Küpeli, Bora; Bozkırlı, İbrahim

doi:10.1007/bf02550555

Cited by 52 publications

(43 citation statements)

References 13 publications

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“…[24][25][26] Sertraline at daily doses of 25-50 mg has been repeatedly reported to improve not only the ejaculation latency time in men with PE but also the control over ejaculation and sexual satisfaction, as evidenced by open-label and controlled studies that reported subsequent increased frequency of intercourse. [27][28][29] Similar to other types of SSRIs, sertraline reaches Cmax within 4-6 h following administration. On the basis of these findings, the current study used EEG to examine the effects of 50 mg sertraline on cerebral activation 4 h after its administration.…”

Section: Discussionmentioning

confidence: 93%

“…In contrast, higher-frequency oscillatory cortical activity, in the range of 40-60 Hz, is seen in less widely dispersed cell assemblies. 8 The highest frequency band can be analyzed by LORETA as a high-frequency beta band (22)(23)(24)(25)(26)(27)(28)(29)(30). The analysis of this frequency band can be helpful when evaluating neurocognitive functions during various situations.…”

Section: Introductionmentioning

confidence: 99%

“…12 In addition, it has a higher selectivity than fluoxetine and paroxetine for blocking the reuptake of 5-HT. 13 To identify the effects of the SSRI sertraline for treating PE, changes in brain current-source density (CSD) of high-frequency beta bands (22)(23)(24)(25)(26)(27)(28)(29)(30) induced by sertraline administration were investigated during audiovisual erotic stimulation.…”

Section: Introductionmentioning

confidence: 99%

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Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

et al. 2011

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To identify the effects of sertraline, a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation (PE), changes in brain current-source density (CSD) of the high beta frequency band (22-30 Hz) induced by sertraline administration were investigated during audiovisual erotic stimulation. Eleven patients with PE (36.9 ± 7.8 yrs) and 11 male volunteers (24.2 ± 1.9 years) were enrolled. Scalp electroencephalography (EEG) was conducted twice: once before sertraline administration and then again 4 h after the administration of 50 mg sertraline. Statistical nonparametric maps were obtained using the EEG segments to detect the current-density differences in the high beta frequency bands (beta-3, 22-30 Hz) between the EEGs before and after sertraline administration in the patient group and between the patient group and controls after the administration of sertraline during the erotic video sessions. Comparing between before and after sertraline administration in the patients with PE, the CSD of the high beta frequency band at 4 h after sertraline administration increased significantly in both superior frontal gyri and the right medial frontal gyrus (Po0.01). The CSD of the beta-3 band of the patients with PE were less activated significantly in the middle and superior temporal gyrus, lingual and fusiform gyrus, inferior occipital gyrus and cuneus of the right cerebral hemisphere compared with the normal volunteers 4 h after sertraline administration (Po0.01). In conclusion, sertraline administration increased the CSD in both the superior frontal and right middle temporal gyrus in patients with PE. The results suggest that the increased neural activity in these particular cerebral regions after sertraline administration may be associated with inhibitory effects on ejaculation in patients with PE.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

et al. 2011

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“…However, in six of these studies, the duration of the baseline period or number of baseline assessments were not mentioned. [33][34][35]67,76,85 Baseline periods ranged from 1 68,69 or 2 26,27 to mostly 4 weeks. 49,57,65,[77][78][79][80]89 In some studies, a certain number of intercourses 41,60,74,81 was taken as baseline measurement.…”

Section: Baseline Periodmentioning

confidence: 99%

Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

et al. 2004

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The aim of this systematic review and meta-analysis is to evaluate whether the design and methodology of drug-treatment studies of premature ejaculation affect the efficacy outcome differently. Therefore, methodological, design and efficacy data from 79 studies (3034 males), published between 1943 and 2003, are reviewed. A meta-analysis is performed on 43 selective serotonin reuptake inhibitors (SSRIs) and clomipramine studies (1514 males), published between 1973 and 2003; these studies were pooled to provide a summary variance-weighted effect size. The antidepressant-induced percentage increase of the intravaginal ejaculation latency time (IELT) was calculated and examined against various methodological items. A significant difference in efficacy between SSRIs was observed. Using daily treatment, paroxetine appeared more effective than the other SSRIs. Retrospective use of a questionnaire, subjective reports, single-blind and open study designs generate far greater variability of ejaculation time both at baseline and during active drug treatment than real time assessment by stopwatch. In conclusion, at daily treatment, the overall efficacy of paroxetine, clomipramine, sertraline and fluoxetine is comparable, but paroxetine exerts the strongest ejaculation delay. Only eight (18.5%) studies on antidepressant treatment fulfilled all criteria used in evidence-based medicine, for example, randomised, double-blind studies with prospective real time (stopwatch) assessment of the IELT at each intercourse. Single-blind studies, open designs, retrospective reporting, or the use of a questionnaire to assess ejaculation time should be avoided.

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“…Ayrıca sertralinin ejakülasyon süresini uzattığına ilişkin çalışmalar vardır. 10 Sonuç olarak, klinisyenlerin hasta muayenelerinde özellikle toplumumuz için konuşulması hastalar için zor olabilen cinsel yan etkiler ayrın-tılarıyla sorgulanmalı ve tedavi seçenekleri aranmalıdır. Olgumuzda yan etki olarak saptanan defekasyon ile ejakülasyonun olası düzeneği, adrenerjik aktivitenin ejakülator latansı azaltması ve spontan ejakülasyonu tetiklemesi olabilir.…”

Section: Discussionunclassified

Duloxetine-induced ejaculation with defacation: a case report

Gündoğmuş¹,

İspir²,

Algül³

et al. 2017

Anadolu Psikiyatri Derg

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Sertraline in the treatment of premature ejaculation: A double-blind placebo controlled study

Cited by 52 publications

References 13 publications

Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis

Duloxetine-induced ejaculation with defacation: a case report

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