Sertraline as an Additional Treatment for Cholestatic Pruritus in Children

Thébaut, Alice; Habès, Dalila; Gottrand, Frédéric; Rivet, Christine; Cohen, Joseph S.; Debray, Dominique; Jacquemin, Emmanuel; Gonzalès, Emmanuel

doi:10.1097/mpg.0000000000001385

Cited by 46 publications

(31 citation statements)

References 19 publications

(22 reference statements)

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“…In a two-armed proof-of-concept study with paroxetine and fluvoxamine, patients with CP of dermatological origin reported a significant antipruritic effect (321). Sertraline proved effective in cholestatic pruritus both in adults (322) and children (323), as well as in CKD-associated pruritus (324,325). In a recent double-blind RCT among 50 haemodialysis patients, sertraline was shown to be effective in reducing uremic pruritus (326), while Doxepin also showed positive effects in 7 patients (304).…”

Section: Gabapentin and Pregabalinmentioning

confidence: 99%

European S2k Guideline on Chronic Pruritus

Weißhaar¹,

Szepietowski²,

Dalgard³

et al. 2019

Acta Derm Venerol

242

201

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ActaDV is a journal for clinical and experimental research in the field of dermatology and venereology and publishes highquality papers in English dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of review articles in special areas, as well as Correspondence to the Editor to stimulate debate. New books are also reviewed. The journal has rapid publication times.

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Section: Gabapentin and Pregabalinmentioning

confidence: 99%

European S2k Guideline on Chronic Pruritus

Weißhaar¹,

Szepietowski²,

Dalgard³

et al. 2019

Acta Derm Venerol

242

201

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“…3 In addition to cholestyramine, it has been shown that ursodiol, rifampin, naltrexone, and now more recently sertraline can be used to treat pruritus medically in patients with cholestasis. 4 Further research has supported the initial findings by Sharp et al in demonstrating the harmful effects of increased bile acids in cholestasis, as well as the use of cholestyramine as treatment for pruritus in such patients. It remains a topic of discussion with further research needed, given the negative impact that cholestatic pruritus has on patients' lives.…”

mentioning

confidence: 58%

50 Years Ago in The Journal of Pediatrics

Whaley

2017

The Journal of Pediatrics

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“…[ 13 ] A prospective multicenter study assessed the efficacy and safety of the serotonin reuptake inhibitor sertraline, for the treatment of children with refractory cholestatic pruritus. [ 14 ] Oliveira et al [ 15 ] thought that the genetic defect in PFIC-3 appears to explains the pathogenesis of intrahepatic cholestasis in pregnancy; their understanding may might provide insights into for developing new therapeutics therapies. After analyzing >150 BSEP mutations, Dröge et al [ 16 ] demonstrated that the extent of exon skipping depends on the genomic and cellular contexts, and that regulation of splicing may have therapeutic potential for PFIC-2.…”

Section: Discussionmentioning

confidence: 99%

Liver transplantation for decompensated liver cirrhosis caused by progressive familial intrahepatic cholestasis type 3

Ding¹,

Wang

et al. 2017

Medicine

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Rationale:Progressive familial intrahepatic cholestasis (PFIC) type 3, characterized by high gamma glutamyl transferase (GGT), is an autosomal recessive genetic disease. It often occurs in patients’ first years of age. However, high GGT type PFIC is still rare.Patient concerns:The present study reports a case of liver transplantation for decompensated liver cirrhosis caused by PFIC type 3. An 18-year-old male presented with a history of abdominal distension and jaundice for 2 months. He had abdominal tenderness but no rebounding pain. Moreover, his dullness was felt over the liver and the spleen was palpable 8 cm below the ribs.Diagnoses:Computed tomography and magnetic resonance cholangiopancreato graphy of the upper abdomen revealed cirrhosis, portal hypertension, collateral circulation formation, large spleen, and ascites. Blood biochemistry showed high alanine transaminase, aspartate transaminase, and GGT. The diagnosis of decompensated liver cirrhosis caused by PFIC-3 was finally confirmed by plasma gene detecting.Interventions:The patient received an open surgery named allogeneic liver transplantation after successful matching of immune types between the recipient and donor. Peritoneal puncture and catheter drainage under B-ultrasound was performed when an encapsulated effusion between the liver and stomach arose.Outcomes:The patient was discharged without specific discomfort and was almost free of fluid accumulation 51 days after the surgery. At the 6-month follow-up, he had no discomfort and the blood routine, liver functions showed no abnormalities.Lessons:We found a new mutant fragment of ABCB4 gene in the process of diagnosis. Liver transplantation remains the most definitive treatment for PFIC. Current medical therapies and surgical interventions such as biliary diversion have potentially created a synergistic outcome.

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Sertraline as an Additional Treatment for Cholestatic Pruritus in Children

Abstract: Our data suggest that sertraline may constitute a useful drug in the management of refractory cholestatic pruritus in children.

Cited by 46 publications

References 19 publications

European S2k Guideline on Chronic Pruritus

European S2k Guideline on Chronic Pruritus

50 Years Ago in The Journal of Pediatrics

Liver transplantation for decompensated liver cirrhosis caused by progressive familial intrahepatic cholestasis type 3

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