Sertoli Cell Tumor of Testis in Childhood

Weitzner, Stanley; Gropp, A.

doi:10.1001/archpedi.1974.02110290111020

Cited by 9 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, our patient had a normal lung examination. The most important cause of prepubertal gynaecomastia that must be ruled out in all instances, is an oestrogen secreting tumour, either adrenal or testicular (Weitzner & Gropp, 1974;Howard et al, 1977). The majority of these tumours are accompanied by masculinization at the time that gynaecomastia is first noted (Itanni et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

Gynaecomasty as the first manifestation of sexual precocity (Case Report)

Ruvalcaba

Moore

2009

Andrologia

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Gynaecomasty as the first manifestation of sexual precocity (Case Report)

Ruvalcaba

Moore

2009

Andrologia

View full text Add to dashboard Cite

show abstract

“…32 Although malignant cases affect mostly adult men, rare metastasizing cases have been reported in prepubertal patients. 33,34 Sertoli cell tumor is a nosologic category that comprises 2 main subtypes: Sertoli cell tumor, not otherwise specified (NOS) and large cell calcifying Sertoli cell tumor (LCCSCT). These tumors have markedly different histopathologic and molecular features and will be discussed separately.…”

Section: Leydig Cell Tumormentioning

confidence: 99%

“…Most cases present as a painless testicular mass, with findings secondary to sex hormone production seen in a relatively minor subset (~10% to 20%) 32 . Although malignant cases affect mostly adult men, rare metastasizing cases have been reported in prepubertal patients 33,34 . Sertoli cell tumor is a nosologic category that comprises 2 main subtypes: Sertoli cell tumor, not otherwise specified (NOS) and large cell calcifying Sertoli cell tumor (LCCSCT).…”

Section: Sertoli Cell Tumormentioning

confidence: 99%

Contemporary Updates on Sex Cord–stromal Tumors of the Testis

Acosta,

Idrees,

Berney

et al. 2023

Advances in Anatomic Pathology

View full text Add to dashboard Cite

Testicular sex cord–stromal tumors (TSCSTs) are relatively rare, representing ~5% of testicular neoplasms overall. Historically, TSCSTs have been classified into 3 major entities: Leydig cell tumor, Sertoli cell tumor, and granulosa cell tumor. In recent years, immunophenotypic and molecular analyses have led to a more detailed understanding of the biological and genomic features of these neoplasms, resulting in the description of new entities, some of which have been included in the latest WHO classification. This review summarizes novel histopathologic, clinical, and molecular findings that may lead to a reappraisal of established concepts and help improve the diagnosis and clinical management of TSCSTs in the coming years.

show abstract

Testicular juvenile granulosa cell and Sertoli cell tumours: A clinicopathological study of 29 cases from the Kiel Paediatric Tumour Registry

Harms

Köck

1997

Virchows Archiv

View full text Add to dashboard Cite

Testicular Sertoli cell tumours (SCT) and juvenile granulosa cell tumours (JGCT) are rare in childhood. This study was designed to investigate the clinical picture, morphology and disease course in a comparatively large series of cases (total number = 29). Of 198 cases of childhood testicular tumour documented in the Kiel Paediatric Tumour Registry 18 were cases of infantile SCT (9.1%) and 11 of JGCT (5.6%). The average age at the time of diagnosis was 4.2 months for infantile SCT and 0.4 months for IGCT. SCT and JGCT often showed infiltrative growth into adjacent testicular tissue, dense cellularity and considerable proliferation activity. Immunohistochemically all cases expressed vimentin intermediate filaments in both tumour types. Next in frequency of expression were cytokeratins (SCT: 7/16; JGCT: 7/10) and smooth-muscle actin (SCT: 9/15; JGCT: 4/10). Follow-up studies (24/29) showed that in cases of tumour manifestation in infancy and after complete tumour removal (usually orchiectomy) no local recurrences and no metastases occurred. The most important conclusion for diagnosis and therapy is that despite infiltrative growth, incomplete differentiation, dense cellularity and considerable proliferation activity, after surgical excision infantile SCT and JGCT have a good prognosis. Adjuvant chemotherapy or more extensive operations with lymphadenectomy are thus not indicated.

show abstract

Sertoli Cell Tumor of Testis in Childhood

Cited by 9 publications

References 12 publications

Gynaecomasty as the first manifestation of sexual precocity (Case Report)

Gynaecomasty as the first manifestation of sexual precocity (Case Report)

Contemporary Updates on Sex Cord–stromal Tumors of the Testis

Testicular juvenile granulosa cell and Sertoli cell tumours: A clinicopathological study of 29 cases from the Kiel Paediatric Tumour Registry

Contact Info

Product

Resources

About