Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications

Hofmann, Marie‐Claude; McBeath, Elena

doi:10.3389/fendo.2022.897062

Cited by 21 publications

(13 citation statements)

References 146 publications

(167 reference statements)

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“…Other modulatory hormones include luteinizing hormone (LH) and folliclestimulating hormone (FSH), which orchestrate hormone synthesis within the gonads (Schiffer et al, 2019). Regulation of testicular steroidogenesis is similarly complex, involving a diversity of critical regulatory pathways, including endocrine, paracrine, autocrine, and juxtacrine mechanisms (Bornstein et al, 2004;Hofmann and McBeath, 2022;Huhtaniemi and Toppari, 1995;O'Hara et al, 2015).…”

Section: Biosynthetic Pathway and Site Of Production Of Steroid Hormonesmentioning

confidence: 99%

Steroid hormone signaling: multifaceted support of testicular function

Matsuyama,

DeFalco

2024

Front. Cell Dev. Biol.

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Embryonic development and adult physiology are dependent on the action of steroid hormones. In particular, the reproductive system is reliant on hormonal signaling to promote gonadal function and to ensure fertility. Here we will describe hormone receptor functions and their impacts on testicular function, focusing on a specific group of essential hormones: androgens, estrogens, progesterone, cortisol, and aldosterone. In addition to focusing on hormone receptor function and localization within the testis, we will highlight the effects of altered receptor signaling, including the consequences of reduced and excess signaling activity. These hormones act through various cellular pathways and receptor types, emphasizing the need for a multifaceted research approach to understand their critical roles in testicular function. Hormones exhibit intricate interactions with each other, as evidenced, for example, by the antagonistic effects of progesterone on mineralocorticoid receptors and cortisol’s impact on androgens. In light of research findings in the field demonstrating an intricate interplay between hormones, a systems biology approach is crucial for a nuanced understanding of this complex hormonal network. This review can serve as a resource for further investigation into hormonal support of male reproductive health.

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Section: Biosynthetic Pathway and Site Of Production Of Steroid Hormonesmentioning

confidence: 99%

Steroid hormone signaling: multifaceted support of testicular function

Matsuyama,

DeFalco

2024

Front. Cell Dev. Biol.

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“…[78][79][80] The Leydig cells are responsible for testosterone production and release and are located in the testicular interstitium, together with fibroblasts, macrophages, blood, and lymphatic vessels. The Sertoli cells along with the Leydig cells can secrete an array of multiple immunosuppressive molecules, including activin A, Transforming Growth Factor beta, and other growth factors, multifunctional cytokines, Programmed Death-Ligand 1 (PD-L1, also known as cluster of differentiation or CD-274 or B7 homolog 1), Growth arrestspecific protein type 6, and testosterone, [81][82][83] among others, which exert either direct or indirect effects, inhibiting/regulating immune cell activation. Since semen is highly immunogenic, these molecules enable its survival and maturation.…”

Section: Monkeypox Virus and Its Atypical Clinical Presentation Durin...mentioning

confidence: 99%

Is monkeypox a new, emerging sexually transmitted disease? A rapid review of the literature

Bragazzi

Kong

2022

Journal of Medical Virology

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Monkeypox, a milder disease compared to smallpox, is caused by a virus initially discovered and described in 1958 by the prominent Danish virologist von Magnus, who was investigating an infectious outbreak affecting monkey colonies. Currently, officially starting from May 2022, an outbreak of monkeypox is ongoing, with 51 000 cases being notified as of September 1, 2022—51 408 confirmed, 28 suspected, and 12 fatalities, for a grand total of 51 448 cases. More than 100 countries and territories are affected, from all the six World Health Organization regions. There are some striking features, that make this outbreak rather unusual when compared with previous outbreaks, including a shift on average age and the most affected age group, affected sex/gender, risk factors, clinical course, presentation, and the transmission route. Initially predominantly zoonotic, with an animal‐to‐human transmission, throughout the last decades, human‐to‐human transmission has become more and more sustained and effective. In particular, clusters of monkeypox have been described among men having sex with men, some of which have been epidemiologically linked to international travel to nonendemic countries and participation in mass gathering events/festivals, like the “Maspalomas (Gran Canaria) 2022 pride.” This review will specifically focus on the “emerging” transmission route of the monkeypox virus, that is to say, the sexual transmission route, which, although not confirmed yet, seems highly likely in the diffusion of the infectious agent.

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“…The fate of these cell populations is closely associated with testicular microenvironment comprised of Sertoli cells (SCs), Leydig cells, myoid cells, along with numerous factors produced by these somatic cells, and the base membrane. Particularly, SCs play a crucial role within the niche as they produce key growth factors for self‐renewal and differentiation of SSCs (Hofmann & McBeath, 2022), as well as mediating intercellular communication to maintain homeostasis (Hai et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Regulation of spermatogonial stem cell differentiation by Sertoli cells‐derived exosomes through paracrine and autocrine signaling

Tian,

Wang,

et al. 2024

Journal Cellular Physiology

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In the orchestrated environment of the testicular niche, the equilibrium between self‐renewal and differentiation of spermatogonial stem cells (SSCs) is meticulously maintained, ensuring a stable stem cell reserve and robust spermatogenesis. Within this milieu, extracellular vesicles, specifically exosomes, have emerged as critical conveyors of intercellular communication. Despite their recognized significance, the implications of testicular exosomes in modulating SSC fate remain incompletely characterized. Given the fundamental support and regulatory influence of Sertoli cells (SCs) on SSCs, we were compelled to explore the role of SC‐derived exosomes (SC‐EXOs) in the SSC‐testicular niche. Our investigation hinged on the hypothesis that SC‐EXOs, secreted by SCs from the testes of 5‐day‐old mice—a developmental juncture marking the onset of SSC differentiation—participate in the regulation of this process. We discovered that exposure to SC‐EXOs resulted in an upsurge of PLZF, MVH, and STRA8 expression in SSC cultures, concomitant with a diminution of ID4 and GFRA1 levels. Intriguingly, obstructing exosomal communication in a SC‐SSC coculture system with the exosome inhibitor GW4869 attenuated SSC differentiation, suggesting that SC‐EXOs may modulate this process via paracrine signaling. Further scrutiny revealed the presence of miR‐493‐5p within SC‐EXOs, which suppresses Gdnf mRNA in SCs to indirectly restrain SSC differentiation through the modulation of GDNF expression—an indication of autocrine regulation. Collectively, our findings illuminate the complex regulatory schema by which SC‐EXOs affect SSC differentiation, offering novel perspectives and laying the groundwork for future preclinical and clinical investigations.

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Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications

Cited by 21 publications

References 146 publications

Steroid hormone signaling: multifaceted support of testicular function

Steroid hormone signaling: multifaceted support of testicular function

Is monkeypox a new, emerging sexually transmitted disease? A rapid review of the literature

Regulation of spermatogonial stem cell differentiation by Sertoli cells‐derived exosomes through paracrine and autocrine signaling

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