Sertaconazole/hydroxypropyl-β-cyclodextrin complexation: Isothermal titration calorimetry and solubility approaches

Complexation and Chiral Drug Recognition of an Amphiphilic Phenothiazine Derivative with β‐Cyclodextrin

“…11 The control of the drug release rate with CDs could be taken advantage of as a potential way to reduce or avoid these complications and, at the same time, to enhance drug solubilization and contribute to reduced toxicity. 17,18 These receptors and their derivatives have been mainly used to simulate a hydrophobic environment in which water-insoluble drugs can be housed increasing the aqueous solubility. 11 In this respect, PTZ presents a suitable amphiphilic structure to form CD complexes, 19 with two differentiated regions, the characteristic aromatic ring of phenothiazines, and an aliphatic charged chain with a chiral carbon (Fig.…”

Clotrimazole–cyclodextrin based approach for the management and treatment of Candidiasis – A formulation and chemistry-based evaluation

“…Modified CDs such as 2-hydroxypropyl-β-cyclodextrin (HPCD) are considered as Inactive Pharmaceutical Ingredients and have been used in oral as well as parenteral formulations in high concentrations. CD derivatives have been effectively utilized to increase the solubility of less water-soluble azoles such as miconazole (18), itraconazole (19) and sertaconazole (20) and have been found to be very successful. The other important factor that can increase the efficacy of a formulation approach is a correct delivery system that favors patient compliance and at the same time does not hinder the release or absorption of the active component.…”

Evaluation of Phenylbutazone and Poly(Amidoamine) Dendrimers Interactions by a Combination of Solubility, 2D-NOESY NMR, and Isothermal Titration Calorimetry Studies

“…The raw experimental data were presented as the total heat generated per second as a function of time and the amount of heat generated per injection was calculated by integration of the area under individual peaks on MicroCal Origin for ITC. After the subtraction of the dilution heat of dendrimer, the experimental data were fitted to a theoretical titration curve,25–30 with calculated enthalpy change (Δ H , kJ/mol), entropy change (Δ S , kJ/mol K), binding affinity ( K a , M −1 ).…”