SERS/TERS Characterization of New Potential Therapeutics: The Influence of Positional Isomerism, Interface Type, Oxidation State of Copper, and Incubation Time on Adsorption on the Surface of Copper(I) and (II) Oxide Nanoparticles

Abstract

The aim of this study was to investigate how the oxidation state of copper (Cu(I) vs Cu(II)), the nature of the interface (solid/aqueous vs solid/air), positional isomerism, and incubation time affect the functionalization of the surface of copper oxide nanostructures by [(butylamino)(pyridine)methyl]phenylphosphinic acid (PyPA). For this purpose, 2-, 3-, and 4-isomers of PyPA and the nanostructures were synthesized. The nanostructure were characterized by UV-visible spectroscopy (UV–vis), scanning electron microscopy (SEM), Raman spectroscopy (RS), and X-ray diffraction (XRD) analysis, which proved the formation of spherical Cu 2 O nanoparticles (Cu 2 ONPs; 1500–600 nm) and leaf-like CuO nanostructures (CuONSs; 80–180/400–700 nm, width/length). PyPA isomers were deposited on the surface of NSs, and adsorption was investigated by surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS). The changes of adsorption on the surface of copper oxide NSs caused by the above-mentioned factors were described and the enhancement factor on this substrate was calculated.

Spectroscopic characterization and in vitro studies of biological activity of bradykinin derivatives

“…In SERS, the energy of the incident radiation is very low and the risk of sample destruction or damage is low, so it can be successfully used to study biological material. SERS uses nanostructures of Ag 24 , Au 25 , and, less commonly, Cu 26 , or other metals 27 , 28 . Metal sols are the most biologically important nanostructures because they ensure low dispersion of nanoparticle diameter in the sol, do not require strict topological control, and provide strong enhancement that decreases dramatically with a continuous metal layer 29 .…”

α-Amido sulphones as useful intermediates in the preparation ofC-chiral α-aminophosphonates and α-aminophosphonic acids

“…Our interest in the preparation of new α-aminophosphonic acids and their esters [36][37][38][39][40] prompted us to investigate the utility of α-amido sulphones as stable imine surrogates and practical intermediates in the preparation of these compounds. Herein we present the results of our research on the preparation of α-aminophosphonic acids and their esters not only as racemic mixtures but also in a highly diastereoselective fashion using a one-pot, effective and simple methodology based on the in situ generation of N-acylimines and their reaction with phosphorus nucleophiles (Scheme 1d).…”

Spectroscopic characterization and in vitro studies of biological activity of bradykinin derivatives

“…In SERS, the energy of the incident radiation is very low and the risk of sample destruction or damage is reduced, thus it can be successfully used to study biological material. SERS uses nanostructures of Ag 20 , Au 21 , and, less commonly, Cu 22 , or other metals 23,24 . Metal sols are the most biologically important nanostructures because they ensure low dispersion of nanoparticle diameter in the sol, do not require strict topological control, and provide strong enhancement that decreases dramatically with a continuous metal layer 25 .…”