SERS investigation of ciprofloxacin drug molecules on TiO₂ nanoparticles

Abstract

In this paper, TiO2 nanoparticles (NPs) with different crystallinity served as SERS-active substrates for SERS detection of ciprofloxacin (CIP) drug molecules for the first time. CIP is close to the surface of the TiO2 substrate through the carboxyl group. The mutual SERS enhancement behaviors between CIP molecules and TiO2 NPs were discovered, which are attributed to the contribution of the TiO2-to-molecule charge-transfer mechanism. The crystallinity of TiO2 NPs, the pH value of adsorption solution and the adsorption time have significant influences on the interaction and the SERS behavior between CIP and TiO2. When the calcination temperature of TiO2 NPs is 450 °C, the pH value of adsorption solution is 6 and the adsorption time is 9 h, the CIP molecules on TiO2 NPs exhibit the largest SERS enhancement.

Ultrasensitive SERS-Based Plasmonic Sensor with Analyte Enrichment System Produced by Direct Laser Writing

“…SERS spectra of the tested drugs are shown in Fig. 5, indicating the ability of the developed sensor to identify their main characteristic fingerprints at corresponding concentration of 1.5 -3 ppb, which were found to be in good agreement with the spectral position of their Raman bands previously reported for similar analytes [67][68][69][70][71][72][73].…”

Influence of 2,4-Diamino-6-Phenyl-1-3-5-triazine on bio synthesized TiO2dye-sensitized solar cell fabricated using poly (ethylene glycol) polymer electrolyte

“…XRD studies The synthesized TiO 2 nanoparticles using Averrhoa bilimbi fruits extract were analyzed by x-ray diffraction spectroscopy. In this figure 1, showed the XRD analysis of synthesized TiO 2 diffraction peaks at 25 [31]. The average crystalline size of green synthesized TiO 2 nanoparticles was found to be 23.8 nm.…”

Sustained release of CIP from TiO2‐PVDF/starch nanocomposite mats with potential application in wound dressing

“…CIP was loaded on TiO 2 nanoparticles following a previously optimized procedure . In this regard, CIP was dissolved in distilled water to reach a concentration of 1 × 10 −3 M followed by the drop‐by‐drop addition of HCl (1 M ) to reach pH = 6.…”

“…Furthermore, using TiO 2 in combination with PVDF intensifies its piezoelectric properties that may indirectly accelerate cell proliferation and decreases the curing timespan. The CIP is able to bind to the TiO 2 NPs through the carboxyl group . Based on the literature, using antibiotic drugs has become so common for local wound applications.…”