SERS from molecules bridging the gap of particle-in-cavity structures

Speed, Jonathon; Johnson, Robert P.; Hugall, James T.; Lal, Niraj N.; Bartlett, Philip N.; Baumberg, Jeremy J.; Russell, Andrea E.

doi:10.1039/c0cc05325b

Cited by 37 publications

(36 citation statements)

References 27 publications

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“…In this arrangement, the enhancement is generated after the nanoparticle has translocated through the nanopore. Simulations and experimentation has shown a strong coupling exists between NPs and metallic nanovoids 44,45 . This interaction will no longer be governed by the NPs position in relation to the nanopore allowing NP stabilization methods, such as silica encapsulation, to be used.…”

mentioning

confidence: 99%

Rapid Ultrasensitive Single Particle Surface-Enhanced Raman Spectroscopy Using Metallic Nanopores

et al. 2013

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Nanopore sensors embedded within thin dielectric membranes have been gaining significant interest due to their single molecule sensitivity and compatibility of detecting a large range of analytes, from DNA and proteins, to small molecules and particles. Building on this concept we utilize a metallic Au solidstate membrane to translocate and rapidly detect single Au nanoparticles (NPs) functionalized with 589 dye molecules using surface enhanced resonance Raman Spectroscopy (SERRS). We show that due to the plasmonic coupling between the Au metallic nanopore surface and the NP, signal intensities are enhanced when probing analyte molecules bound to the NP surface. Although not single molecule, this nanopore sensing scheme benefits from the ability of SERS to provide rich vibrational information on the analyte, improving on current nanopore-based electrical and optical detection techniques. We show that the full vibrational band of the analyte can be detected with ultra-high spectral sensitivity, and rapid temporal resolution of 880 µs.

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confidence: 99%

Rapid Ultrasensitive Single Particle Surface-Enhanced Raman Spectroscopy Using Metallic Nanopores

et al. 2013

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“…This has provided a better understanding as to how the geometry underpins the enhancements. Recently, metallic structure designs have emerged where both localised plasmons as well as a strong coupling to external light is achieved [25][26][27][28][29][30][31][32][33][34]. Of these designs, inverted pyramidal substrates (also known as Klar-ite®) are now well understood with respect to optimal cavity size to achieve the so called 'resonant plasmon cavity' [25,28,29,35,36].…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of a 3D-structured gold film with nanopores for local electric field enhancement in the pore

Grant-Jacob

Carpignano

et al. 2015

Nanotechnology

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Three-dimensionally structured gold membrane films with nanopores of defined, periodic geometries are designed and fabricated to provide the spatially localised enhancement of electric fields by manipulation of the plasmons inside nanopores. Square nanopores of different size and orientation relative to the pyramid are considered for films in aqueous and air environments, which allow for control of the position of electric fields within the structure. Designs suitable for use with 780 nm light were created. Here, periodic pyramidal cavities produced by potassium hydroxide etching to the {111} planes of (100) silicon substrates are used as templates for creating a periodic, pyramidal structured, free-standing thin gold film. Consistent with the findings from the theoretical studies, a nano-sized hole of 50 nm square was milled through the gold film at a specific location in the cavity to provide electric field control which can subsequently used for enhancement of fluorescence or Raman scattering of molecules in the nanopore.

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“…In our previous article, we also have successfully assembled silver nanoparticles (AgNPs) into silver cavities through the connecting of 4‐aminothiophenol (PATP) molecules. More recently, Speed et al . demonstrated that the fabrication of a particle‐in‐cavity (PIC) structure can result in a great increase in the SERS enhancement of the bridging molecules between the gold cavities and the nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Surface enhanced Raman scattering of molecules related to highly ordered gold cavities

Tian

Zhou

et al. 2013

J Raman Spectroscopy

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We presented a controlled particles-in-cavity (PIC) pattern for surface-enhanced Raman scattering (SERS) detection. The periodic gold cavity array was fabricated by electrodeposition using highly ordered polystyrene spheres as a template. The as-prepared gold cavities can be used as a SERS active substrate with significant spectral enhancement and reproducibility, which was evaluated by SERS signals using 4-mercaptobenzoic acid (4-MBA) as probe molecules. The surface of these gold cavities was further functionalized with cetyltrimethylammonium bromide molecules, which may immobilize the 4-MBA-modified silver nanoparticles in the gold cavity to form a PIC structure via the electrostatic interaction. We have demonstrated that there exists a pH window for the immobilization of the nanoparticles inside cavities. Therefore, the silver nanoparticles can be selectively immobilized into the functionalized gold cavities under the optimized pH value of the media. Further enhancement of the Raman scattering of the labeled molecules can be achieved due to the interconnection between the silver nanoparticles and gold cavity.

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SERS from molecules bridging the gap of particle-in-cavity structures

Abstract: We demonstrate that by combining silver nanoparticles and structured gold SSV surfaces the SERS for those molecules that bridge the nanoparticle-cavity gap is preferentially enhanced using 4-mercaptoaniline and 4-mercaptobenzoic acid as examples.

Cited by 37 publications

References 27 publications

Rapid Ultrasensitive Single Particle Surface-Enhanced Raman Spectroscopy Using Metallic Nanopores

Rapid Ultrasensitive Single Particle Surface-Enhanced Raman Spectroscopy Using Metallic Nanopores

Design and fabrication of a 3D-structured gold film with nanopores for local electric field enhancement in the pore

Surface enhanced Raman scattering of molecules related to highly ordered gold cavities

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