SERS detection of expired tetracycline hydrochloride with an optical fiber nano-probe

Jin, Di; Bai, Yuxue; Chen, Haige; Liu, Shupeng; Chen, Na; Huang, Jing; Huang, Sujuan; Chen, Zhenyi

doi:10.1039/c4ay02725f

Cited by 33 publications

(15 citation statements)

References 48 publications

(70 reference statements)

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“…2a, a set of more pronounced peaks appear in the TET spiked milk at 1280 cm −1 , 1322 cm −1 and 1621 cm −1 . This evidence is in accordance with the TET characteristic peaks reported in the literature 6,35 although with a small shift, due to the interaction of the TET with the milk matrix. The peak at 1280 cm −1 is correlated to bending modes of C-H in the positions 4, 4a, 5, 5a, O-H12 and amid-NH and to stretching modes of C10, 3-O, C-H7, 8, 9, C4a-C5 and amid-NC.…”

Section: Resultssupporting

confidence: 92%

Paper-Based SERS Platform for One-Step Screening of Tetracycline in Milk

Marques

Veigas

Araújo

et al. 2019

Sci Rep

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Throughout the last decade, the expansion of food testing has been gradually moving towards ordinary high throughput screening methods performed on-site. The demand for point-of-care testing, able to distinguish molecular signatures with high accuracy, sensitivity and specificity has been significantly increasing. This new requirement relies on the on-site detection and monitorization of molecular signatures suitable for the surveillance of food production and processing. The widespread use of antibiotics has contributed to disease control of livestock but has also created problems for the dairy industry and consumers. Its therapeutic and subtherapeutic use has increased the risk of contamination in milk in enough concentrations to cause economic losses to the dairy industry and have a health impact in highly sensitive individuals. This study focuses on the development of a simple Surface-Enhanced Raman Spectroscopy (SERS) method for fast high throughput screening of tetracycline (TET) in milk. For this, we integrate a paper-based low-cost, fully recyclable and highly stable SERS platform, with a minimal sample preparation protocol. A two-microliter sample of milk solutions spiked with TET (from 0.01 to 1000 ppm) is dried on a silver nanoparticle coated cardboard substrate and measured via a Raman spectrophotometer. The SERS substrate showed to be extremely stable with a shelf life of several months. A global spectrum principal component analysis approach was used to test all the detected vibrational modes and their correlation with TET concentration. Peak intensity ratios (455 cm−1/1280 cm−1 and 874 cm−1/1397 cm−1) were found to be correlated with TET concentrations in milk, achieving a sensitivity as low as 0.1 ppm. Results indicate that this SERS method combined with portable Raman spectrometer is a potential tool that can be used on-site for the monitoring of TET residues and other antibiotics.

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Section: Resultssupporting

confidence: 92%

Paper-Based SERS Platform for One-Step Screening of Tetracycline in Milk

Marques

Veigas

Araújo

et al. 2019

Sci Rep

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“…Although most of the applications are focused on planar substrates for Lab-On-a-Chip (LOC) applications [95,96], optical fiber approaches have been also reported using nanoparticle decorated tapered optical fibers [94,[97][98][99][100]. Another example can be found in [94] where it is reported that silver nanoplates were deposited on the tapered surface of an optical fiber with the LbL technology (Figure 8).…”

Section: Surface-enhanced Raman Spectroscopy (Sers)mentioning

confidence: 99%

Optical Fiber Sensors Based on Nanoparticle-Embedded Coatings

2015

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The use of nanoparticles (NPs) in scientific applications has attracted the attention of many researchers in the last few years. The use of NPs can help researchers to tune the physical characteristics of the sensing coating (thickness, roughness, specific area, refractive index, etc.) leading to enhanced sensors with response time or sensitivity better than traditional sensing coatings. Additionally, NPs also offer other special properties that depend on their nanometric size, and this is also a source of new sensing applications. This review focuses on the current status of research in the use of NPs within coatings in optical fiber sensing. Most used sensing principles in fiber optics are briefly described and classified into several groups: absorbance-based sensors, interferometric sensors, fluorescence-based sensors, fiber grating sensors, and resonance-based sensors, among others. For each sensor group, specific examples of the utilization of NP-embedded coatings in their sensing structure are reported.

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“…Surface enhanced raman scattering (SERS) is a non-destructive and powerful tool that not only offers high specificity and sufficient structural information of chemical and biological molecules [1]- [3], but also provides enormous enhancement for the SERS effect, making it suitable for applications in trace analysis, environmental monitoring, biochemical sensing, and food safety, etc [4]- [6]. Due to the enhancement of electromagnetic fields around metal nanostructures (typically silver and gold), the Raman signal of analyte molecules in the immediate vicinity of the nanostructures could be increase drastically by about orders of 10 6 or even more [7], [8].…”

Section: Introductionmentioning

confidence: 99%

Sensitivity-Enhanced U-Shaped Fiber SERS Probe With Photoreduced Silver Nanoparticles

Yin

Geng

et al. 2016

IEEE Photonics J.

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This paper presents a novel U-shaped fiber surface-enhanced Raman scattering (SERS) spectra probe with high-performance remote sensing based on femtosecond laser ablation and deposition of photoreduced silver nanoparticles. As the width of the U-shaped structure is around 12 m, the sensitivity is enhanced about four times more than that of a single-endface-based fiber SERS probe. The experiment results show that there is a nonlinear relationship between the SERS signal and the width of the U-shaped structure, whereas the SERS signal is sharply decreased with the increasing width of the U-shape. Our U-shaped fiber SERS probe shows a feasible method for high-performance, real-time, and remote measurement of the SERS signal in biochemical analysis.

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SERS detection of expired tetracycline hydrochloride with an optical fiber nano-probe

Cited by 33 publications

References 48 publications

Paper-Based SERS Platform for One-Step Screening of Tetracycline in Milk

Paper-Based SERS Platform for One-Step Screening of Tetracycline in Milk

Optical Fiber Sensors Based on Nanoparticle-Embedded Coatings

Sensitivity-Enhanced U-Shaped Fiber SERS Probe With Photoreduced Silver Nanoparticles

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