SERS detection of ceftriaxone and sulfadimethoxine using copper nanoparticles temporally protected by porous calcium carbonate

Markina, Natalia E.; Волкова, Е. В.; Zakharevich, Andrey M.; Goryacheva, Irina Yu.; Маркин, А. В.

doi:10.1007/s00604-018-3018-9

Cited by 22 publications

(10 citation statements)

References 34 publications

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“…Particular attention has been paid to the substrates based on metallic nanoparticles incorporated into porous (in)organic matrices [10][11][12]. These substrates improve colloidal and chemical stability of the nanoparticles and possess better sorption capabilities compared with the pure nanoparticles [13,14]. For example, the improvement of limits of detection up to several orders has been demonstrated in several reports including ours [15,16].…”

Section: Introductionmentioning

confidence: 99%

Determination of methotrexate in spiked human urine using SERS-active sorbent

2020

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This report is dedicated to determination of anticancer drug methotrexate (MTX) in human urine using surface-enhanced Raman spectroscopy (SERS). Aluminum oxide loaded with silver nanoparticles (AO-Ag) was proposed as SERS-active sorbent and used for solid-phase extraction (SPE) of the analyte and its SERS-based determination (SPE-SERS protocol). MTX has strong SERS signal only in alkaline media that challenges its determination in urine due to strong background signal caused by creatinine. The application of SPE step enables to purify and concentrate the analyte making MTX determination possible. Also, the application of the same material for SPE pretreatment and SERS analysis enables to simplify and speed-up the protocol. The protocol was developed and tested using artificially spiked samples of human urine collected during different time of day to account deviating composition of the urine matrix. The use of dilution step of the analyte-containing urine was proposed prior SPE-SERS protocol to reduce the difference between morning-time-and daytime-collected urine achieving maximal reliability of the analysis. Additional physicochemical study was performed to estimate an influence of the primary intrinsic urine components (salts, urea, creatinine) and their mixtures on the analytical signal. Final protocol enables MTX determination in human urine within 20-300 μg mL −1 range of concentrations with satisfactory precision (11-19% RSD), accuracy (97-104% apparent recovery), and limit of detection (4.2 μg mL −1). Accounting that the analysis requires less than 15 min and portable Raman spectrometer, the protocol seems to be promising for therapeutic drug monitoring in hospitals to identify poor MTX clearance in a timely manner and minimize adverse effects of therapy.

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Section: Introductionmentioning

confidence: 99%

Determination of methotrexate in spiked human urine using SERS-active sorbent

2020

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“…variations between different substrates of the same type would introduce unacceptable quantification errors. Currently, standard deviations of about 20% are still considered reasonable [72]. However, clinical and forensic applications must fulfill much higher standards and require significant improvements.…”

Section: Advances In Sers Substrate Development For Drug Sensing Applmentioning

confidence: 99%

Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy

Knebl

Frosch

2019

Nanophotonics

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Innovations in Raman spectroscopic techniques provide a potential solution to current problems in pharmaceutical drug monitoring. This review aims to summarize the recent advances in the field. The developments of novel plasmonic nanoparticles continuously push the limits of Raman spectroscopic detection. In surface-enhanced Raman spectroscopy (SERS), these particles are used for the strong local enhancement of Raman signals from pharmaceutical drugs. SERS is increasingly applied for forensic trace detection and for therapeutic drug monitoring. In combination with spatially offset Raman spectroscopy, further application fields could be addressed, e.g. in situ pharmaceutical quality testing through the packaging. Raman optical activity, which enables the thorough analysis of specific chiral properties of drugs, can also be combined with SERS for signal enhancement. Besides SERS, micro- and nano-structured optical hollow fibers enable a versatile approach for Raman signal enhancement of pharmaceuticals. Within the fiber, the volume of interaction between drug molecules and laser light is increased compared with conventional methods. Advances in fiber-enhanced Raman spectroscopy point at the high potential for continuous online drug monitoring in clinical therapeutic diagnosis. Furthermore, fiber-array based non-invasive Raman spectroscopic chemical imaging of tablets might find application in the detection of substandard and counterfeit drugs. The discussed techniques are promising and might soon find widespread application for the detection and monitoring of drugs in various fields.

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“…The following functionalization them with magnetic nanoparticles will prove a possibility to move such SERS platforms under the magnetic field (Parakhonskiy et al, 2019). In addition, porous calcium carbonate particles have been shown to prolong the stability and detection capability of silver nanoparticles (Markina et al, 2018). An appropriate platform for deposition of such particles are scaffolds, for which electrospinning (ES) appears to be a very attractive fabrication technique (Prikhozhdenko et al, 2016;Saveleva et al, 2017;Chernozem et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Polycaprolactone-Based, Porous CaCO3 and Ag Nanoparticle Modified Scaffolds as a SERS Platform With Molecule-Specific Adsorption

et al. 2020

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Surface-enhanced Raman scattering (SERS) is a high-performance technique allowing detection of extremely low concentrations of analytes. For such applications, fibrous polymeric matrices decorated with plasmonic metal nanostructures can be used as flexible SERS substrates for analysis of analytes in many application. In this study, a three-dimensional SERS substrate consisting of a CaCO 3-mineralized electrospun (ES) polycaprolactone (PCL) fibrous matrix decorated with silver (Ag) nanoparticles is developed. Such modification of the fibrous substrate allows achieving a significant increase of the SERS signal amplification. Functionalization of fibers by porous CaCO 3 (vaterite) and Ag nanoparticles provides an effective approach of selective adsorption of biomolecules and their precise detection by SERS. This new SERS substrate represents a promising biosensor platform with selectivity to low and high molecular weight molecules.

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SERS detection of ceftriaxone and sulfadimethoxine using copper nanoparticles temporally protected by porous calcium carbonate

Cited by 22 publications

References 34 publications

Determination of methotrexate in spiked human urine using SERS-active sorbent

Determination of methotrexate in spiked human urine using SERS-active sorbent

Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy

Polycaprolactone-Based, Porous CaCO3 and Ag Nanoparticle Modified Scaffolds as a SERS Platform With Molecule-Specific Adsorption

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