SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease

Gao, Feng; Li, Fang; Wang, Jianhao; Yu, Hang; Li, Xiang; Chen, Hongyu; Wang, Jiabei; Qin, Dongdong; Li, Yiyi; Liu, Songyan; Zhang, Xi; Wang, Zhi-Hao

doi:10.3390/bios13090880

Cited by 4 publications

(2 citation statements)

References 138 publications

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“…Using SERS to analyze AD biomarkers holds tremendous potential for accurate and early diagnosis. SERS-based biosensors have been developed, harnessing the optical properties of NPs to enhance detection performance [80]. Yu et al have developed a sensitive SERS-based method to quantitatively detect serum biomarkers (such as Aβ1-42 and P-Tau-181) for early diagnosis of AD [81].…”

Section: The Use Of Sers In Alzheimer's Disease Researchmentioning

confidence: 99%

Advancing Brain Research through Surface-Enhanced Raman Spectroscopy (SERS): Current Applications and Future Prospects

Elsheikh,

Coles,

Achadu

et al. 2024

Biosensors

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Surface-enhanced Raman spectroscopy (SERS) has recently emerged as a potent analytical technique with significant potential in the field of brain research. This review explores the applications and innovations of SERS in understanding the pathophysiological basis and diagnosis of brain disorders. SERS holds significant advantages over conventional Raman spectroscopy, particularly in terms of sensitivity and stability. The integration of label-free SERS presents promising opportunities for the rapid, reliable, and non-invasive diagnosis of brain-associated diseases, particularly when combined with advanced computational methods such as machine learning. SERS has potential to deepen our understanding of brain diseases, enhancing diagnosis, monitoring, and therapeutic interventions. Such advancements could significantly enhance the accuracy of clinical diagnosis and further our understanding of brain-related processes and diseases. This review assesses the utility of SERS in diagnosing and understanding the pathophysiological basis of brain disorders such as Alzheimer’s and Parkinson’s diseases, stroke, and brain cancer. Recent technological advances in SERS instrumentation and techniques are discussed, including innovations in nanoparticle design, substrate materials, and imaging technologies. We also explore prospects and emerging trends, offering insights into new technologies, while also addressing various challenges and limitations associated with SERS in brain research.

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Section: The Use Of Sers In Alzheimer's Disease Researchmentioning

confidence: 99%

Advancing Brain Research through Surface-Enhanced Raman Spectroscopy (SERS): Current Applications and Future Prospects

Elsheikh,

Coles,

Achadu

et al. 2024

Biosensors

View full text Add to dashboard Cite

show abstract

“…Surface-enhanced Raman spectroscopy (SERS) has aroused increasing research interest in analytical and biological chemistry because of its highly specific molecular fingerprint information, fast detection speed, and noninvasive and on-site analysis [ 91 , 92 ]. Nanostructured plasmonic materials, including gold, silver, and copper, can enhance the Raman signal via the electromagnetic enhancement mechanism.…”

Section: Redox Cycling-based Optical Bioassaysmentioning

confidence: 99%

Optical Bioassays Based on the Signal Amplification of Redox Cycling

Feng,

Gao,

et al. 2024

Biosensors

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Optical bioassays are challenged by the growing requirements of sensitivity and simplicity. Recent developments in the combination of redox cycling with different optical methods for signal amplification have proven to have tremendous potential for improving analytical performances. In this review, we summarized the advances in optical bioassays based on the signal amplification of redox cycling, including colorimetry, fluorescence, surface-enhanced Raman scattering, chemiluminescence, and electrochemiluminescence. Furthermore, this review highlighted the general principles to effectively couple redox cycling with optical bioassays, and particular attention was focused on current challenges and future opportunities.

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