SERS and EC dual-mode detection for dopamine based on WO3-SnO2 nanoflake arrays

Polyhedral Au Nanoparticle/MoOx Heterojunction-Enhanced Ultrasensitive Dual-Mode Biosensor for miRNA Detection Combined with a Nonenzymatic Cascade DNA Amplification Circuit

“…Significant SERS signals were obtained by the combination of multistage free-enzyme DNA tandem amplification and the excellent synergistic enhancement effect of the PAMS substrate material. Advantageously, MB not only has Raman activity but also serves as an EC signal indicator. , Strong EC signals could also be obtained due to the large enrichment of the signal probes on the GAM substrate and the fast charge transfer between the MB and the heterojunction materials. The intensities of the obtained EC signal and SERS signal were both related to the concentration of the target miRNA, which enabled the proposed analytical system to achieve dual-mode amplification detection of target molecules.…”

“…27,28 Recently, SERS-EC dualmode detection platforms have demonstrated unique advantages in the field of biological analysis. 29,30 Moreover, by combining various DNA amplification technologies, such as catalytic hairpin assembly (CHA), strand replacement, and hybridization chain reaction (HCR), higher sensitivity has been achieved. 31−33 Although some progress has been made, it remains highly challenging to select an appropriate detection substrate and signal amplification strategy for SERS-EC dualmode detection platforms to achieve accurate and sensitive miRNA analysis.…”

“…In addition, the accuracy of biomolecule detection in a complex matrix represents another focus of clinical diagnostics. The dual-mode detection method based on two different response mechanisms has a self-calibration function, which can provide more comprehensive and reliable information than the single-mode sensing system, thereby showing its great potential in the early diagnosis of cancer and other diseases. , Electrochemical (EC) techniques have been widely used in the analysis of biological samples due to their convenience, rapidity, and high sensitivity. , Recently, SERS-EC dual-mode detection platforms have demonstrated unique advantages in the field of biological analysis. , Moreover, by combining various DNA amplification technologies, such as catalytic hairpin assembly (CHA), strand replacement, and hybridization chain reaction (HCR), higher sensitivity has been achieved. − Although some progress has been made, it remains highly challenging to select an appropriate detection substrate and signal amplification strategy for SERS-EC dual-mode detection platforms to achieve accurate and sensitive miRNA analysis.…”

Recent Research Progress of Surface‐Enhanced Raman Scattering Dominated Analysis Strategies in Early Diagnosis of Diseases

“…The LOD of "nanomolar" level was obtained, and this biosensing platform revealed good specificity and reliability. [171] EIS has been often used to analyze the change of biosensor surface via the measurement of resistance and capacitance. For instance, castaño-guerrero et al developed a sandwich type immune SERS-electrochemical biosensor based on antibodymodified Au-SPE (Figure 8B).…”

FeS2-based aerogel as a flexible low-cost substrate for rapid SERS detection of histamine in biofluids

“…It is therefore necessary to develop simple, rapid, and more sensitive analytical strategies to detect histamines. 5,6 Recently, low-cost, surface-enhanced Raman scattering (SERS) sensing platforms have been intensively studied for chemical and biological analysis at high throughput. Due to high sensitivity and molecular specificity, SERS is among the most promising analytical techniques for detecting trace amounts of molecules.…”