SERS Activity of Semiconductors: Crystalline and Amorphous Nanomaterials

Wang, Xiaotian; Guo, Lin

doi:10.1002/ange.201913375

Cited by 29 publications

(41 citation statements)

References 65 publications

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“…NiO is a wide band gap, p-type semiconductor and therefore a very good candidate for charge transfer. Crystalline functionalized nanoprobes generated SERS by combined effect of charge transfer and electromagnetic enhancement …”

Section: Resultsmentioning

confidence: 99%

“…Therefore, it is possible to characterize CSCs based on multiple parameters simultaneously. SERS provides an intuitive tool for exploring the complex landscape of CSCs (proteins, lipids, metabolites, DNA/RNA) with trace level detection sensitivity . This technique is capable of distinguishing the slightest variation in the molecular orientation, making it possible to easily explain structural changes .…”

mentioning

confidence: 99%

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Prediction of Cancer Stem Cell Fate by Surface-Enhanced Raman Scattering Functionalized Nanoprobes

et al. 2020

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Cancer stem cells (CSCs) are the fundamental building blocks of cancer dissemination, so it is desirable to develop a technique to predict the behavior of CSCs during tumor initiation and relapse. It will provide a powerful tool for pathological prognosis. Currently, there exists no method of such prediction. Here, we introduce nickel-based functionalized nanoprobe facilitated surface enhanced Raman scattering (SERS) for prediction of cancer dissemination by undertaking CSC-based surveillance. SERS profiling of CSCs of various cell lines (breast cancer, cervical cancer, and lung cancer) was compared with their cancer counterparts for the prediction of prognosis, with statistical significance of single-cell sensitivity. The single-cell sensitivity is critical as even a few CSCs are capable of initiating a tumor. Intermediate states of CSC transmutation to cancer cells and its reverse were monitored, and nanoprobe-assisted SERS profiling was undertaken. We experimentally demonstrated that the quasi-intermediate CSC states have dissimilar profiles during the transformation from cancer to CSC and vice versa enabling statistical differentiation without ambiguity. It was also observed that molecular signatures of these opposite pathways are cancer-type specific. This observation provided additional clarity to the current understanding of relatively unfamiliar quasi-intermediate states; making it possible to predict CSC dissemination for variety of cancers with ∼99% accuracy. Nano probe-based prediction of CSC fate is a powerful prediction tool for ultrasensitive prognosis of malignancy in a complex environment. Such CSC-based cancer prognosis has never been proposed before. This prediction technique has potential to provide insights for cancer diagnosis and prognosis as well as for obtaining information instrumental in designing of meaningful CSC-based cancer therapeutics.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Prediction of Cancer Stem Cell Fate by Surface-Enhanced Raman Scattering Functionalized Nanoprobes

et al. 2020

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“…Nickel oxide is a good material for charge transfer as it is a wide band gap, p-type semi-conductor. [43] Highest enhancement was observed at 532 nm excitation, which was attributed to the highest energy at the short wavelength. As shown in Figure S1 in the Supporting Information, this observation was also confirmed with FDTD simulation.…”

Section: Functionalized Quantum Superstructure-assisted Molecular Lev...mentioning

confidence: 92%

“…[ 46 ] Enhancement of Raman signal resulted due to the photon trapping in the multiple layers of the quantum superstructures. [ 43 ] In addition to the charge transfer resonance, presence of three dimensional superstructures instrumental in generation of multiple hot spots simultaneously must have resulted in a reproducible SERS.…”

Section: Functionalized Quantum Superstructure‐assisted Molecular Lev...mentioning

confidence: 99%

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Cancer Stem Cell DNA Enabled Real‐Time Genotyping with Self‐Functionalized Quantum Superstructures—Overcoming the Barriers of Noninvasive cfDNA Cancer Diagnostics

et al. 2022

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efficacy and reduce mortality. [1] Unfortunately, diagnosis of cancer at advanced stage leading to poor survival could be attri buted to the molecular heterogeneity of the tumors [2] in addition to the clonal evolution during tumor progression. [3] The dynamically changing tumor landscape also poses a significant challenge for clinical management, necessitating a real-time assessment of tumor states for informed decision-making and treatment optimization. Although extensively used in the clinic, radiographic imaging techniques such as MRI, CT, PET often fail to detect the shifts in tumor burden. [4] Conventional tissue biopsy is highly invasive, restricted to a localized snapshot of the tumor and highly unrepeatable. Hence, new tools to supplement the existing clinical tools are the immediate necessity for accurate tracking of tumor dynamics to enhance cancer prognostic prediction for the best possible treatment.Liquid biopsy (LB) offers an excellent solution for cancer diagnosis and treatment optimization. [5,6] As circulating tumor DNA (ctDNA) can present multitude of relevant tumor information across a variety of clinical contexts [6] such as tumor burden, [7] tumor-specific genomic alterations, [1] tumor heterogeneity; [8] cell-free DNA (cfDNA) including circulating tumor DNA (ctDNA) is rapidly developing Cancer diagnosis and determining its tissue of origin are crucial for clinical implementation of personalized medicine. Conventional diagnostic techniques such as imaging and tissue biopsy are unable to capture the dynamic tumor landscape. Although circulating tumor DNA (ctDNA) shows promise for diagnosis, the clinical relevance of ctDNA remains largely undetermined due to several biological and technical complexities. Here, cancer stem cell-ctDNA is used to overcome the biological complexities like the inability for molecular analysis of ctDNA and dependence on ctDNA concentration rather than the molecular profile. Ultrasensitive quantum superstructures overcome the technical complexities of trace-level detection and rapid diagnosis to detect ctDNA within its short half-life. Activation of multiple surface enhanced Raman scattering mechanisms of the quantum superstructures achieved a very high enhancement factor (1.35 × 10 11 ) and detection at ultralow concentration (10 −15 M) with very high reliability (RSD: 3-12%). Pilot validation with clinical plasma samples from an independent validation cohort achieved a diagnosis sensitivity of ≈95% and specificity of 83%. Quantum superstructures identified the tissue of origin with ≈75-86% sensitivity and ≈92-96% specificity. With large scale clinical validation, the technology can develop into a clinically useful liquid biopsy tool improving cancer diagnostics.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smtd.202101467.

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Surface‐Enhanced Raman Scattering in BIC‐Driven Semiconductor Metasurfaces

Hu,

Pal,

Berestennikov

et al. 2024

Advanced Optical Materials

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Semiconductor‐based surface‐enhanced Raman spectroscopy (SERS) substrates, as a new frontier in the field of SERS, are hindered by their poor electromagnetic field confinement and weak light‐matter interaction. Metasurfaces, a class of 2D artificial materials based on the electromagnetic design of nanophotonic resonators, enable strong electromagnetic field enhancement and optical absorption engineering for a wide range of semiconductors. However, the engineering of semiconductor substrates into metasurfaces for improving SERS activity remains underexplored. Here, an improved SERS metasurface platform is developed that leverages the combination of titanium oxide (TiO2) and the emerging physical concept of optical bound states in the continuum (BICs) to boost the Raman emission. Moreover, fine‐tuning of BIC‐assisted resonant absorption offers a pathway for maximizing the photoinduced charge transfer effect (PICT) in SERS. High values of BIC‐assisted electric field enhancement (|E/E0|2 ≈103) are achieved, challenging the preconception of weak electromagnetic (EM) field enhancement on semiconductor SERS substrates. The BIC‐assisted TiO2 metasurface platform offers a new dimension in spectrally‐tunable SERS with earth‐abundant and bio‐compatible semiconductor materials, beyond the traditional plasmonic ones.

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SERS Activity of Semiconductors: Crystalline and Amorphous Nanomaterials

Cited by 29 publications

References 65 publications

Prediction of Cancer Stem Cell Fate by Surface-Enhanced Raman Scattering Functionalized Nanoprobes

Prediction of Cancer Stem Cell Fate by Surface-Enhanced Raman Scattering Functionalized Nanoprobes

Cancer Stem Cell DNA Enabled Real‐Time Genotyping with Self‐Functionalized Quantum Superstructures—Overcoming the Barriers of Noninvasive cfDNA Cancer Diagnostics

Surface‐Enhanced Raman Scattering in BIC‐Driven Semiconductor Metasurfaces

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