Serratia rubidaea as an invasive pathogen

Ursua, P R; Unzaga, M.J.; Melero, P; Iturburu, I.; Ezpeleta, Carmen; Cisterna, R

doi:10.1128/jcm.34.1.216-217.1996

Cited by 35 publications

(18 citation statements)

References 12 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Serratia strains other than of S. marcescens have also been implicated in a variety of infections. For example, S. odorifera caused pneumonia and sepsis (Cook & Lopez, 1998;Lee et al, 2006); S. ficaria caused endophthalmitis and sepsis (Darbas et al, 1994;Badenoch et al, 2002); S. quinivorans caused pneumonia (Bollet et al, 1993); S. fonticola was isolated from a leg abscess (Bollet et al, 1991); invasive properties have been attributed to S. rubidaea (Ursua et al, 1996); S. liquefaciens caused transfusion-related sepsis (Roth et al, 2000), and outbreaks have been reported in a critical care unit and in a neurosurgery department (Harnett et al, 2001;Dubouix et al, 2005); and S. plymuthica is regarded as a significant opportunistic pathogen (Berg, 2000) to which a variety of infections including peritonitis, pneumonia, sepsis and wound infections have been attributed (Clark & Janda, 1985;Reina et al, 1992;Domingo et al, 1994;Carrero et al, 1995;Nouh & Bhandari, 2000). The increasing number of documented infections caused by such strains and the difficult identification of these bacteria by commercial systems urges for a more detailed investigation of the physiology, virulence and taxonomy of this genus (Stock et al, 2003).…”

Section: The Genus Serratiamentioning

confidence: 99%

Quorum sensing inSerratia

2007

View full text Add to dashboard Cite

Many bacteria use cell-cell communication to monitor their population density, synchronize their behaviour and socially interact. This communication results in a coordinated gene regulation and is generally called quorum sensing. In gram-negative bacteria, the most common quorum signal molecules are acylated homoserine lactones (AHLs), although other low-molecular-mass signalling molecules have been described such as Autoinducer-2 (AI-2). The phenotypes that are regulated in Serratia species by means of AHLs are remarkably diverse and of profound biological and ecological significance, and often interconnected with other global regulators. Furthermore, AHL- and AI-2-mediated systems (less profoundly studied) are continuously being discovered and explored in Serratia spp., many having interesting twists on the basic theme. Therefore, this review will highlight the current known quorum sensing systems in Serratia spp., including the important nosocomial pathogen Serratia marcescens.

show abstract

Section: The Genus Serratiamentioning

confidence: 99%

Quorum sensing inSerratia

2007

View full text Add to dashboard Cite

show abstract

“…The genus Serratia rubidaea is gram-negative speculator pathogens, known to survive harsh environmental surroundings and is a leading cause of hospital acquired infections. This species was first described as Bacterium rubidaea in 1940 and presently recognized as S. rubidaea [1]. Serratias are widely distributed saprophytic bacterium and has been found in soil, air, water as well as plants.…”

Section: Introductionmentioning

confidence: 99%

“…Treatment of S. rubidaea infection is often complicated by multidrugresistant phenotypes. This species has essential resistance to several antimicrobial groups, including some classes of beta-lactams and tetracyclines [1,2,5]. The expansion of this multidrug resistant pattern suggests that the treatment of S. rubidaea infections will become increasingly difficult in the future.…”

Section: Introductionmentioning

confidence: 99%

Antagonistic activity ofBacillus amyloliquefacienssubsp.amyloliquefaciensagainst multidrug resistantSerratia rubidaea

Afrin

Bhuiyan

2019

Preprint

View full text Add to dashboard Cite

Serratia rubidaea a member of the Enterobacteriaceae family, is a Gram-negative opportunistic pathogen, known to survive harsh environmental conditions and responsible for hospital associated infections. Specifically, S. rubidaea can withstand desiccation and survive on hospital surfaces and equipments as well as have acquired antimicrobial resistance determinants for different commercial antibiotics. The expansion of this multidrug resistant pattern suggests that the treatment of S. rubidaea infections will become increasingly difficult in near future. Although some measures were taken to control this species, an inhibition mechanism is remaining unknown. To design effective means to control the dissemination of S. rubidaea, an in-depth analysis is required. In the present study, one possible candidate was isolated from the soil of Sundarban Mangroove Forest (Bangladesh) that has important physiological effects to inhibit this pathogenic bacterium. The bacterial isolate was initially identified as Bacillus amyloliquefaciens subsp. amyloliquefaciens using BIOLOG TM identification system and confirmed to be B. amyloliquefaciens strain through 16 S rDNA sequence analysis. The growth and antagonistic activity of this potential strain was shown to be stable under wide range of pH, temperature and salinity (NaCl). Moreover, the novel B. amyloliquefaciens isolate can also inhibit Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and other pathogenic bacteria. These results suggest that B. amyloliquefaciens might have potential antimicrobial properties and further research is required for future use of this bacterium as biological controls of S. rubidaea or development as new drugs for pathogenic bacteria.

show abstract

“…ShlA triggers internalization of the bacteria followed by irreversible vacuolization and lysis of epithelial cells (Hertle and Schwarz, 2004). In addition, a number of reports describe human diseases from infections with other Serratia species including Serratia rubidaea, Serratia liquefaciens, Serratia grimesii and Serratia proteamaculans (Bollet et al, 1993;Ursua et al, 1996;Hertle, 2005;Grimont and Grimont, 2006). Serratia has also been associated with animal infections being involved in septicaemia, conjunctivitis and other diseases in domestic animals (Grimont and Grimont, 2006).…”

Section: Introductionmentioning

confidence: 99%

Bacterial invasion of eukaryotic cells can be mediated by actin-hydrolysing metalloproteases grimelysin and protealysin

et al. 2010

View full text Add to dashboard Cite

Earlier, we have shown that spontaneously isolated non-pathogenic bacteria Serratia grimesii and Serratia proteamaculans invade eukaryotic cells, provided that they synthesize thermolysin-like metalloproteases ECP32/grimelysin or protealysin characterized by high specificity towards actin. To address the question of whether the proteases are active players in entry of these bacteria into host cells, in this work, human larynx carcinoma Hep-2 cells were infected with recombinant Escherichia coli expressing grimelysin or protealysin. Using confocal and electron microscopy, we have found that the recombinant bacteria, whose extracts limitedly cleaved actin, were internalized within the eukaryotic cells residing both in vacuoles and free in cytoplasm. The E. coli-carrying plasmids without inserts of grimelysin or protealysin gene did not enter Hep-2 cells. Moreover, internalization of non-invasive E. coli was not observed in the presence of protealysin introduced into the culture medium. These results are consistent with the direct participation of ECP32/grimelysin and protealysin in entry of bacteria into the host cells. We assume that ECP32/grimelysin and protealysin mediate invasion being injected into the eukaryotic cell and that the high specificity of the enzyme towards actin may be a factor contributed to the bacteria internalization.

show abstract

Serratia rubidaea as an invasive pathogen

Abstract: Serratia rubidaea biotype 1 was isolated from the bile and blood of a patient with a bile tract carcinoma obstructing the common bile duct and who underwent invasive procedures. The infection was cleared after adequate treatment with antibiotics.

Cited by 35 publications

References 12 publications

Quorum sensing inSerratia

Quorum sensing inSerratia

Antagonistic activity ofBacillus amyloliquefacienssubsp.amyloliquefaciensagainst multidrug resistantSerratia rubidaea

Bacterial invasion of eukaryotic cells can be mediated by actin-hydrolysing metalloproteases grimelysin and protealysin

Contact Info

Product

Resources

About