Serrated lesions and hyperplastic (serrated) polyposis relationship with colorectal cancer: classification and surveillance recommendations

Orłowska, Janina

doi:10.1016/j.gie.2013.02.016

Cited by 16 publications

(21 citation statements)

References 106 publications

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“…Among them, 96% (76/77) had reasons for undergoing colonoscopy that included colorectal polyp history, family history of CRC, and clinical symptoms suggestive of CRC. Because of this selection bias, the estimation of CRC risk is likely to be inflated and reflect a CRC risk associated with symptomatic patients 283334. On the contrary, more than half of the patients (60%) in the present study underwent colonoscopy for screening purposes.…”

Section: Discussionmentioning

confidence: 80%

“…Serrated polyposis syndrome (SPS), previously known as hyperplastic polyposis, is a rare condition characterized by multiple serrated polyps (SPs) spread throughout the colon and rectum 123. Since SPS is a somewhat complex syndrome whose molecular basis is not yet clearly understood, the World Health Organization (WHO) developed consensus criteria for the clinical diagnosis of SPS 4.…”

Section: Introductionmentioning

confidence: 99%

“…These inclusions might have produced an overestimated CRC risk 212. Furthermore, most previous studies were performed in Western countries.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients

et al. 2017

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Background/AimsSerrated polyposis syndrome (SPS) has been shown to increase the risk of colorectal cancer (CRC). However, little is known about the characteristics of Asian patients with SPS. This study aimed to identify the clinicopathological features and risk of CRC in Korean patients with SPS as well as the differences between Korean and Western patients based on a literature review.MethodsThis retrospective study included 30 patients with SPS as defined by World Health Organization classification treated at Samsung Medical Center, Korea, between March 1999 and May 2011.ResultsTwenty patients (67%) were male. The median patient age at diagnosis was 56 years (range, 39–76 years). A total of 702 polyps were identified during a median follow-up of 43 months (range, 0–149 months). Serrated polyps were noted more frequently in the distal colon (298/702, 55%). However, large serrated polyps and serrated adenomas were mainly distributed throughout the proximal colon (75% vs. 25% and 81% vs. 19%, respectively); 73.3% had synchronous adenomatous polyps. The incidence of CRC was 10% (3/30 patients), but no interval CRC was detected. A total of 87% of the patients underwent esophagogastroduodenoscopy and 19.2% had significant lesions.ConclusionsThe phenotype of SPS in Korean patients is different from that of Western patients. In Korean patients, SPS is more common in men, there were fewer total numbers of serrated adenoma/polyps, and the incidence of CRC was lower than that in Western patients. Korean patients tend to more frequently have abnormal gastric lesions. However, the prevalence of synchronous adenomatous polyps is high in both Western and Korean patients.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients

et al. 2017

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“…Jass has provided evidence that hyperplastic polyps (HPs) in the proximal colon might serve as precursors of colon cancers through DNA methylation and deficient DNA mismatch repair [5]. They have also been the focus of a growing body of clinical literature [6].…”

Section: Introductionmentioning

confidence: 99%

Insertion water exchange increases right colon adenoma and hyperplastic polyp detection rates during withdrawal

Cadoni¹,

Falt

Sanna³

et al. 2016

Digestive and Liver Disease

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“…They are believed to be endowed with a small potential for carcinogenetic change – especially in light of their potential link with cancer in hyperplastic polyposis syndrome as well as cases of cancer arising in hyperplastic tissue [22, 23]. Several morphological subtypes of hyperplastic polyps are recognized – namely microvesicular, goblet cell rich and mucin poor.…”

Section: Discussionmentioning

confidence: 99%

Cyclooxygenase-2 immunohistochemical expression in serrated polyps of the colon

Kiedrowski¹,

Mróz

Kraszewska

et al. 2014

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Aim of the studyCyclooxygenase-2 (COX-2) expression has been observed in a substantial percentage of classical adenomas of the large bowel. The aim of the study was to assess and compare the expression of COX-2 in serrated polyps of the colon.Material and methodsOne hundred and nineteen serrated polyps were analyzed. There were 83 hyperplastic polyps (HP), 19 sessile serrated polyps (SSP) and 17 traditional serrated adenomas (TSA). COX-2 expression was assessed semi-quantitatively (0–2) and each lesion was fully characterized in terms of anatomical location, size, histology, age and sex of the patient. The general estimating equation (GEE) model with logit link was used in the statistical analysis.ResultsEpithelial expression of COX-2 was found in 85/119 serrated polyps (71.43%): 57/83 (68.67%) HP, 16/19 (84.21%) SSP, and 12/17 (70.59%) TSA. In HP and SSP it was predominantly of weak (49/83 HP, 12/19 SSP), whereas in TSA it was mainly of medium/strong intensity (8/17). The TSA category was associated with more frequent COX-2 expression (OR = 7.00, 95% CI: 1.49–32.88, p = 0.014) than HP, but such relation was not found for SSP vs. HP (p > 0.1). No associations between COX-2 expression and clinical parameters were found.ConclusionsImmunohistochemical COX-2 expression cannot serve as a diagnostic adjunct to differentiate HP and SSP.

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Serrated lesions and hyperplastic (serrated) polyposis relationship with colorectal cancer: classification and surveillance recommendations

Cited by 16 publications

References 106 publications

Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients

Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients

Insertion water exchange increases right colon adenoma and hyperplastic polyp detection rates during withdrawal

Cyclooxygenase-2 immunohistochemical expression in serrated polyps of the colon

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