SerpinI2 (pancpin) is an inhibitory serpin targeting pancreatic elastase and chymotrypsin

Three new genes associated with longevity in the European Bison

“…These proteins act in the regulation of a variety of physiological processes including coagulation, fibrinolysis, development, malignancy and inflammation ( Law et al., 2006 ). Expression of the encoded protein is downregulated in pancreatic and breast cancer and it is associated with acinar cell apoptosis and pancreatic insufficiency when absent in mice ( Higgins, Grehan, Wynne & Worrall, 2017 ). SERPINI2 deficient mice are growth retarded, have abnormal immunity and reduced lifespan ( Loftus et al., 2005 ).…”

Avian genomics lends insights into endocrine function in birds

“…These observations suggest that a genetic compensation for a possible RNL3 loss would be immediately present for most vertebrates, but not for non-eutherian mammals. Lastly, SERPINI2, while not directly associated with a weight or insulin-related phenotype, is known to be downregulated in pancreatic carcinogenesis, suggesting at least an indirect link with pancreatic function (Chang et al, 2000; Higgins et al, 2017; Ozaki et al, 1998).…”

Identificação e anotação funcional de novos transcritos com expressão alterada no câncer pancreático

“…O lncRNA DLEU1 (aumentado em nossas amostras tumorais) foi recentemente encontrado "up-regulated" em PDAC e experimentos "knockdown" inibiram proliferação, migração e invasão in vitro e reduziram o tumor in vivo (S. Gao et al 2018) . Enquanto que entre os genes com expressão diminuída destacam-se: SERPINI2 : membro da superfamília serpin, inibe elastase e quimiotripsina pancreática, protegendo as células do pâncreas de zimógenos ativados prematuramente (Higgins et al 2017) . CPA2 : A Carboxipeptidase A2 é uma proteína monomérica secretada que atua nos resíduos aromáticos C-terminal, também foi descrita com expressão diminuída em pacientes com Adenocarcinoma Pancreático Ductal (PDAC) em diversos estudos (Grützmann et al 2004;Tian et al 2008) .…”