SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway

Tian, Shan; Peng, Pailan; Li, Jiao; Deng, Huan; Zhan, Na; Zeng, Zhi; Dong, Weiguo

doi:10.18632/aging.102831

Cited by 137 publications

(122 citation statements)

References 42 publications

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“…A previous study demonstrated that OS progression is associated with the transcriptional activity of activated β‐catenin 23 . Besides, some studies have also shown that MMP2 is closely associated with the Wnt/β‐catenin signalling pathway 24‐26 . This study validates that LINC01128 affects MMP2 mRNA stability through competitive binding with miR‐299‐3p.…”

Section: Resultssupporting

confidence: 78%

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LINC01128 regulates the development of osteosarcoma by sponging miR‐299‐3p to mediate MMP2 expression and activating Wnt/β‐catenin signalling pathway

Yao

Chen

2020

J Cellular Molecular Medi

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Section: Resultssupporting

confidence: 78%

“…23 Besides, some studies have also shown that MMP2 is closely associated with the Wnt/β-catenin signalling pathway. [24][25][26] This study…”

Section: Linc01128 and Mmp2 Jointly Activate The Wnt/β-catenin Signmentioning

confidence: 92%

LINC01128 regulates the development of osteosarcoma by sponging miR‐299‐3p to mediate MMP2 expression and activating Wnt/β‐catenin signalling pathway

Yao

Chen

2020

J Cellular Molecular Medi

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“…The process of EMT mechanism in tumor cells is highly correlated with numerous signal transduction pathways as well as multiple regulators. Among them, Wnt/b-catenin signaling pathway plays an important role in EMT of GC cells (26). Wnt/b-catenin signaling pathway is one of the most important signaling pathways leading to the development and progression of GC.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: FNDC1 Promotes the Invasiveness of Gastric Cancer via Wnt/β-Catenin Signaling Pathway and Correlates With Peritoneal Metastasis and Prognosis

et al. 2020

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BackgroundGastric cancer (GC) has a high morbidity and mortality rate, with peritoneal metastasis (PM) identified as the main site of metastasis. Our previous study found that FNDC1 has a higher frequency of mutations in patients with PM by high-throughput sequencing assay, suggesting that it may be associated with GC invasion and PM, however the specific mechanism remains unclear.MethodsFirst, the correlation between FNDC1 and PM and prognosis of GC was clarified by bioinformatics and clinicopathological analysis. Next, the effect of FNDC1 expression on the invasion and metastasis ability of GC was investigated in vivo and in vitro. Finally, the signaling pathways involved in the regulation of FNDC1 were explored.ResultsFNDC1 was highly expressed in GC and was associated with PM and poor prognosis. FNDC1 was also associated with epithelial-mesenchymal transition (EMT) in GC cells. Through in vivo and in vitro experiments, it was clarified that knockdown of FNDC1 could inhibit the proliferation, invasion, and migration of GC cells. In addition, it was elucidated that FNDC1 promotes EMT through the Wnt/β-catenin signaling pathway.ConclusionFNDC1 may be associated with the invasion of GC and PM after surgery. FNDC1 was highly expressed in GC tissues and cell lines, while significantly associated with poor DFS and OS in GC patients. Both univariate and multivariate analyses suggested that the expression of FNDC1 was an independent factor for GC. Knockdown of FNDC1 also significantly inhibited the proliferation, migration, and activity of GC cells. FNDC1 may promote EMT in GC cells through the regulation of Wnt/β-catenin signaling pathway. FNDC1 has the potential to be used as a predictor of PM and may also be studied in depth as a therapeutic target for GC, which has potential clinical utility and is worthy of further validation.

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“…The results indicate that suppressed HOXC‐AS1 could inhibit the EMT process, whereas sh‐elf4AIII could restore it. Our previous research also found that the EMT process, proliferation and apoptosis could be restricted by inhibition of β‐catenin, supporting the regulatory role of the Wnt/β‐catenin signaling pathway in the cellular functions in GC 16,20,21 . As a result, we concluded that silenced HOXC‐AS1 could act as an inhibitor for cancer cell proliferation and EMT and as a promoter for cell apoptosis by binding elf4AIII via the Wnt/β‐catenin pathway.…”

Section: Discussionsupporting

confidence: 70%

lncRNA HOXC‐AS1 promotes gastric cancer via binding eIF4AIII by activating Wnt/β‐catenin signaling

Zhou¹,

Cao

et al. 2020

The Journal of Gene Medicine

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Background Long non‐coding RNAs (lncRNAs) function as oncogenes or tumor suppressor genes in several cancers. The present study aimed to determine the functions of lncRNA HOXC‐AS1 in gastric cancer (GC) in vitro. Methods A quantitative reverse transcriptase‐polymerase chain reaction (qRT‐PCR) was used to measure the expression of lncRNA HOXC‐AS1 in GC cell lines and normal cells. After silencing HOXC‐AS1 in GC cells, a cell counting kit‐8 assay monitored the viability of the cells. qRT‐PCR and western blot documented the EMT key genes in response to HOXC‐AS1 change. qRT‐PCR detected mRNA expression for eIF4AIII in GC and normal cell lines and cell viability was measured after an increase and decrease of eIF4AIII. RNA pull‐down and qRT‐PCR confirmed the binding in between. Apoptosis was compared by flow cytometry. The interplay between the two genes was surveyed by introduction of the sh‐HOXC‐AS1 and sh‐eIF4AIII and by assessing cell viability, EMT and Wnt/β‐catenin signaling. Results lncRNA HOXC‐AS1 expression is up‐regulated in GC cells and a decrease of lncRNA HOXC‐AS1 inhibited cell viability. Binding was validated by RNA pull‐down. Additionally, inhibition of eIF4AIII induced an increase of lncRNA HOXC‐AS1, thus promoting cell proliferation and the EMT process but deterring apoptosis of gastric cancer cells. Wnt/β‐catenin signaling was impeded by HOXC‐AS1 inhibition but restored by suppression of eIF4AIII. Conclusions HOXC‐AS1 may promote the proliferation and the EMT process and inhibit apoptosis by binding eIF4AIII via Wnt/β‐catenin signaling, which indicates that HOXC‐AS1/eIF4AIII might be an axis that could be further used as a biomarker to help with the diagnosis of GC.

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SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway

Cited by 137 publications

References 42 publications

LINC01128 regulates the development of osteosarcoma by sponging miR‐299‐3p to mediate MMP2 expression and activating Wnt/β‐catenin signalling pathway

LINC01128 regulates the development of osteosarcoma by sponging miR‐299‐3p to mediate MMP2 expression and activating Wnt/β‐catenin signalling pathway

RETRACTED: FNDC1 Promotes the Invasiveness of Gastric Cancer via Wnt/β-Catenin Signaling Pathway and Correlates With Peritoneal Metastasis and Prognosis

lncRNA HOXC‐AS1 promotes gastric cancer via binding eIF4AIII by activating Wnt/β‐catenin signaling

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