SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma

Dhanda, Jagtar; Triantafyllou, Asterios; Lilogou, T.; Kalarai, H.; Hanlon, Rebecca; Lloyd, Bryony H.; Shaw, Richard; Sibson, Ross

doi:10.1016/j.bjoms.2015.08.213

Cited by 5 publications

(7 citation statements)

References 45 publications

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“…We also reported that high serpinE1 expression was associated with a higher risk of metastases and poor clinical outcome in an independent HNSCC patient analysis . Similar findings have been described by other authors, supporting the close association between serpinE1 overexpression and HNSCC oncogenesis and tumor dissemination . However, whether serpinE1 is functionally involved in the progression or dissemination in HNSCC remains unknown.…”

Section: Introductionsupporting

confidence: 90%

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma

et al. 2018

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Background Serpin Family E Member 1 (SerpinE1) overexpression associates with poor clinical outcome in head and neck squamous cell carcinoma (HNSCC) patients. This study analyzed the role of serpinE1 in HNSCC dissemination. Methods We studied the phenotypic characteristics and dissemination of HNSCC cells overexpressing serpinE1 using an orthotopic model and the association between serpinE1 overexpression and clinicopathological variables in patients included in The Cancer Genome Atlas database. Results SerpinE1 overexpression increased proliferation, tumor budding, and the stromal component, while inhibiting apoptosis in primary tumors. It also enhanced the affectation and metastatic growth in lymph nodes, and the dispersion and growth of metastatic foci in the lung. High serpinE1 expression was associated with larger tumor size, undifferentiated tumors, lymph node metastasis, extracapsular spread, and the presence of perineural and angiolymphatic invasion. Conclusion SerpinE1 overexpression promotes tumor aggressiveness and metastatic dissemination to lymph nodes and lung consistently with its association with poor outcome in HNSCC patients.

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Section: Introductionsupporting

confidence: 90%

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma

et al. 2018

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“…B). As it was previously reported a correlation between α‐SMA staining and survival for oral and tongue tumours , but not for other sites of mouth and head and neck, we analysed separately HNSCC at other sites and found that there was a correlation between the pattern of α‐SMA staining at tumour front and survival for other sites of HNSCC than tongue (Fig. D).…”

Section: Resultsmentioning

confidence: 84%

“…The presence of myofibroblasts in the stroma of tongue and oral cancer has been associated with poor prognosis by several studies . Integrin‐mediated interactions between extracellular matrix and the cytoskeleton seem to promote myofibroblast differentiation .…”

Section: Introductionmentioning

confidence: 99%

Integrin α11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression

Parajuli

Teh

Abrahamsen

et al. 2016

J Oral Pathology Medicine

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BackgroundCancer‐associated fibroblasts (CAFs) were shown to be important for tumour progression in head and neck squamous cell carcinomas (HNSCCs). Their heterogeneity and lack of specific markers is increasingly recognized. Integrin α11 was recently shown to be expressed by CAFs and might serve as a specific CAF marker.AimTo investigate integrin α11 expression and its correlation with the expression of a well‐known marker of CAF, alpha smooth muscle actin (α‐SMA), in HNSCC.MethodsFresh frozen (FF) and formalin‐fixed paraffin‐embedded (FFPE) samples from healthy volunteers (n = 24), oral lichen planus (OLP) (n = 32) and HNSCC (n = 106) were collected together with clinical data after ethical approval. Immunohistochemistry to detect integrin α11 and α‐SMA was performed on FF and FFPE samples. qPCR for integrin α11 (ITGA11) and α‐SMA (ACTA2) was performed on FF samples. Data were analysed using chi‐square test and Kaplan–Meier survival analysis.ResultsSignificantly higher levels of integrin α11 and α‐SMA at both protein and mRNA levels were found in HNSCC vs. normal controls and OLP. A strong correlation was found between integrin α11 and α‐SMA expression, and double staining showed their colocalization. Both integrin α11 and α‐SMA were detected surrounding metastatic islands. Expression of α‐SMA at tumour front but not tumour centre correlated with patient survival.ConclusionIntegrin α11 was overexpressed in HNSCC stroma and colocalized with α‐SMA. Expression of α‐SMA at tumour front but not tumour centre had prognostic value for survival, pinpointing the importance of assessing tumour front when evaluating stromal molecules as prognostic biomarkers.

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“…CAFs have been suggested widely involved in tumor proliferation, invasion, and metastasis in various malignancies . In OSCC, accumulating clinical data have revealed the presence of CAFs and its positive correlations with the invasive phenotype , presence of local recurrence and lymphatic metastasis , even poor survival of the patients . Experiments in vitro have also revealed CAFs can stimulate proliferation and invasion of OSCC cells.…”

Section: Introductionmentioning

confidence: 99%

Significance of oral cancer‐associated fibroblasts in angiogenesis, lymphangiogenesis, and tumor invasion in oral squamous cell carcinoma

Lin

Wang

Zhao

et al. 2016

J Oral Pathology Medicine

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SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma

Cited by 5 publications

References 45 publications

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma

Integrin α11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression

Significance of oral cancer‐associated fibroblasts in angiogenesis, lymphangiogenesis, and tumor invasion in oral squamous cell carcinoma

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