Serpentes de interesse em saúde

Paiva, Diego De Assis Moura Rodrigues De

doi:10.32749/nucleodoconhecimento.com.br/biologia/interesse-em-saude

Revista Científica Multidisciplinar Núcleo do Conhecimento

2020

DOI: 10.32749/nucleodoconhecimento.com.br/biologia/interesse-em-saude

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Serpentes de interesse em saúde

Diego De Assis Moura Rodrigues De Paiva¹

Abstract: Este trabalho busca expor a biologia e fisiologia das serpentes consideradas de interesse em saúde no Brasil, como os gêneros, Bothrops, Crotalus, Lachesis e Micrurus e sua importância ecossistêmica. Assim sendo, o artigo tem como objetivo principal apresentar uma súmula nos quesitos, serpentes e serpentes peçonhentas. A metodologia utilizada foi o levantamento através de pesquisas bibliográficas nas principais bases de dados, Repitile Data Base, SBH, Google Acadêmico, Scielo, Pubmed, entre os anos de 1995 até… Show more

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2023

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Evaluation of the Toxicological Effects from Bothrops Jararacussu Snake Venom on Zebrafish (Danio Rerio) Embryos and Larvae

Marchi-Salvador

Silva

Oliveira

et al. 2023

VAT

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Introduction: Approximately 90% of reported and identified cases of snakebites in Brazil are caused by species belonging to the Bothrops genus. These snakes have clinical relevance due to their venom composition, which contains substances capable of triggering local and systemic effects, leading to morbidities and/or mortality. Objective: The objective of this study was to evaluate the toxic and toxinological effects of Bothrops jararacussu snake venom on zebrafish embryos and larvae. Methods: The stability of B. jararacussu snake venom under the conditions used in the toxicity experiments in zebrafish embryos and larvae was evaluated on citrated human plasma. Zebrafish embryos and/or larvae mortality, morphological alterations, spontaneous tail movements and heartbeat caused by the venom were quantified within 96 hours. Toxicity parameters and activity of enzyme-related toxicity biomarkers were evaluated in zebrafish after 96 hours of semi-static exposure to the venom. Results: The results indicated that the venom causes toxicity in zebrafish embryos and larvae, inducing embryonic mortality, alteration in the number of spontaneous tail movements and activity of biomarker enzymes. The results suggested that the toxic effects caused by the venom in the early stages of zebrafish development are mediated, in part, by neurotoxic action, induction of oxidative and metabolic stress caused by low molecular weight components, and proteins present in this venom. Conclusion: Toxinological evaluations using the zebrafish as a model are scarce; however, this study presented promising results that encourage the development of future research in toxinology using this animal as a model organism.

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Evaluation of the Toxicological Effects from Bothrops Jararacussu Snake Venom on Zebrafish (Danio Rerio) Embryos and Larvae

Marchi-Salvador

Silva

Oliveira

et al. 2023

VAT

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Incidência Nacional De Acidentes De Crotalus Sp E Sua Implicância Nos Casos Graves De Injúria Renal Aguda (Ira)

Rulli,

De Paiva,

Thomazine

2023

Rev. Foco

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As cascavéis, gênero Crotalus, são responsáveis pelo segundo acidente ofídico mais incidente no Brasil. Os acidentes crotálicos são capazes de causar uma rápida perda da função renal e necrose das células dos túbulos renais, levando a uma injúria renal aguda (IRA). As toxinas presentes na peçonha são de ação neurotóxica, miotóxica e coagulante, as quais são responsáveis por causarem danos renais, neurológicos, musculares e hematológicos. Sendo assim, quanto antes for iniciado o tratamento adequado, maior a chance reverter o quadro, prevenir IRA e salvar o paciente. Por fim, o conhecimento dos profissionais sobre o diagnóstico e tratamento dos acidentes ofídicos é extremamente necessário por se tratar de uma doença tropical prevalente no Brasil.

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Serpentes de interesse em saúde

Cited by 2 publications

References 14 publications

Evaluation of the Toxicological Effects from Bothrops Jararacussu Snake Venom on Zebrafish (Danio Rerio) Embryos and Larvae

Evaluation of the Toxicological Effects from Bothrops Jararacussu Snake Venom on Zebrafish (Danio Rerio) Embryos and Larvae

Incidência Nacional De Acidentes De Crotalus Sp E Sua Implicância Nos Casos Graves De Injúria Renal Aguda (Ira)

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