SERPENCELESSNESS OF ANTIBODIES TO SARS-CoV-2 IN CHILDREN AGAINST THE BACKGROUND OF THE COVID-19 EPIDEMIC IN THE RUSSIAN FEDERATION

Popova, А. Yu.; Смирнов, В. С.; Andreeva, E. E.; Arbuzova, Tatyana; Babura, None; Balakhonov, S. V.; Башкетова, Н. С.; Бугоркова, С. А.; Bulanov, M.V.; Valeullina, N.N.; Goryaev, D.V.; Gubanova, A. V.; Detkovskaya, N.N.; Ежлова, Е. Б.; Zhimbaeva, Oyuna B; Zaitseva, N.N.; Зуева, Е. В.; Иванов, В. А.; Istorik, O.A.; Kovalchuk, I.V.; Козловских, Д. Н.; Kombarova, S.Y.; Курганова, О. П.; Lomovtsev, A.E.; Lukicheva, L.A.; Мельникова, А. А.; Микаилова, О. М.; Миличкина, А. М.; Носков, А. К.; Noskova, L.N.; Oglezneva, E.E.; Osmolovskaya, T.P.; Патяшина, М. А.; Penkovskaya, N.A.; Petrova, Olga Aleksandrovna; Razumovskaya, Alexandra P; Samoilova, L.V.; Степанова, Татьяна; Троценко, О. Е.; Khamitova, Irina V.; Тотолян, Арег А.

doi:10.24110/0031-403x-2022-101-3-85-97

Cited by 3 publications

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“…At the beginning of the pandemic (summer-autumn 2020), there were age differences in seroprevalence almost throughout Russia. Despite the fact that the number of children with COVID-19 was small, the seroprevalence of SARS-CoV-2 Abs in children was higher than the average value for the entire cohort or the value in adults [9]. One of the most likely reasons for this phenomenon could be a high frequency of asymptomatic or mildly-symptomatic infections in the children's age group.…”

Section: Resultsmentioning

confidence: 86%

“…25, № 4 proceeded under the guise of a common cold without serious clinical manifestations, yet accompanied by serological changes. Thus, in the process of seromonitoring conducted in 2020-2021, among seropositive children, the proportion of individuals with asymptomatic infection exceeded 90% [9]. In addition, age-related reduced ACE-2 receptor density, and cross-immunity to closely related seasonal coronaviruses, may have markedly reduced susceptibility to SARS-CoV-2 [1,3].…”

Section: закономерности коллективного иммунитета к Covid-19mentioning

confidence: 99%

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Patterns in the development of collective immunity to SARS-CoV-2 during the COVID-19 pandemic

Popova

Смирнов

et al. 2023

Med. immunol.

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The ongoing coronavirus disease (COVID-19) pandemic over the past three years has caused close attention to the problem of herd immunity, which is understood as: "resistance to the spread of a contagious disease within a population or herd". Collective immunity is formed both as a result of infection (natural spread of the pathogen in a population of susceptible individuals) and as a result of the use of specific vaccines. During the COVID-19 pandemic, both mechanisms for the formation of collective immunity were realized. In the first wave, there was a natural formation of collective immunity to the virus following recoveries from COVID-19 caused by pandemic spread of SARS-CoV-2. Starting from December 2020, the widespread use of specific vaccines against SARS-CoV-2 began in the USA, Great Britain, China, Russia, and a number of other countries. This launched the process of post-vaccination collective immunity formation; its features have depended on the vaccine types implemented. Currently, in those countries where vaccination and revaccination of recovered patients is widely carried out, immunity is "hybrid" in nature. Several commonalities should be noted in the pandemic experience: a somewhat regular, periodic (wavelike) nature of the COVID-19 epidemic process; changes in pathogen genetics in variants in all countries; and expansive mass vaccination programs in many populations. From these, we can draw some conclusions about the general trend for all countries in the formation of collective immunity during the pandemic: At the beginning of the pandemic in 2020, overall population seroprevalence did not exceed 20%. Other findings were: the highest seroprevalence rates were noted in the children's age group; pronounced regional differences were revealed; and the highest indicators were noted among medical workers. Collective immunity developed as a result of infection or illness, and in the majority of seropositive volunteers, it was represented by antibodies to both antigens. At the height of the pandemic in the summer of 2021, population seroprevalence reached 50%. This was due to both a significant number of convalescents and the start of mass vaccination campaigns. In all countries, specific differences in seroprevalence (by age, region, profession) leveled out, leading to more uniformity. During this period, the formation of "hybrid" immunity is clearly prominent, and the proportion of individuals with antibodies to RBD alone increased (due to vaccination with vector vaccines). Later, mass vaccination, as well as involvement of most of the population in the epidemic process due to the emergence of the highly contagious Omicron strain, raised the level of collective immunity to 80-90%. This led to a sharp decrease in COVID-19 incidence in the second half of 2022 in all countries participating in the study. In the later stages of the pandemic (2022-2023), almost 90% of seropositive volunteers had hybrid immunity, reflected as antibodies to both antigens (Nc, RBD).

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Section: Resultsmentioning

confidence: 86%

Section: закономерности коллективного иммунитета к Covid-19mentioning

confidence: 99%

Patterns in the development of collective immunity to SARS-CoV-2 during the COVID-19 pandemic

Popova

Смирнов

et al. 2023

Med. immunol.

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Assessment of indicators of specific humoral immune against COVID-19 in children during the distribution of a new coronavirus infection in the Irkutsk region (2020–2021)

Брюхова

Дубровина

Киселева

et al. 2023

Acta biomedica scientifica

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Background. There are many aspects of the development of immunity to the SARSCoV-2 virus, that remain poorly understood, like the influence of age-related characteristics on the intensity of immunity and the course of the disease. Studies of the state of immunity are widely used, mainly in the adults. But questions of the patho- and immunogenesis in children remain unsolved. Determining the nature of seroconversion of antibodies to SARS-CoV-2 in this age group is important information for serological monitoring for targeted immunoprophylaxis of the population and forecasting the epidemic situation in the region.The aim. Evaluation of the dynamics of seroprevalence of specific antibodies to SARS-CoV-2 in children of the Irkutsk region during the pandemic of a new coronavirus infection.Materials and methods. Study was conducted among the child population of the Irkutsk region in the period June 2020 – December 2021 as part of the Rospotrebnadzor project to assess population immunity to SARS-CoV-2 in the population of the Russian Federation. The content of antibodies to SARS-CoV-2 was determined by ELISA using native commercial test systems.Results. Population immunity among the child population of the Irkutsk region was characterized by an upward trend from 7.8 % at stage 1 to 98.4 % at stage 6 of the study. IgG to SARS-CoV-2 remained in 72.8 % and formed in 25.6 % of previously seronegative children. Antibodies were detected in 66.1 % of cases and persisted for up to 10–15 months after COVID-19 infection. The proportion of asymptomatic forms of infection among seropositive volunteers was 69.5 %, which determines the high intensity of the latent epidemic process.Conclusion. The level of seroprevalence was 98.4%. The current results of serological monitoring serve as a scientific basis for adjusting the list and scope of management decisions on the organization of preventive anti-epidemic measures, including vaccination.

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Assessment of the level of immune layer to SARS-CoV-2 in children under conditions of novel coronavirus infection COVID-19

Евсеева

Lazareva

Vlasova

et al. 2023

Bûlletenʹ fiziologii i patologii dyhaniâ

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Introduction. Asymptomatic transmission of the coronavirus poses a significant threat to efforts to reduce the incidence of COVID-19. A specific humoral immune response against SARS-CoV-2 can be induced in most symptomatic cases and in asymptomatic carriers. Determining the pattern of antibody response to SARS-CoV-2 infection in children can provide important information for improving screening and targeted protection of population that continue to suffer from this pandemic. Aim. To determine the level of antibodies to SARS-CoV-2 in children during the COVID19 epidemic. Materials and methods. Serum samples from 254 clinic patients from 1 to 17 years old, with an average age of 9.7±0.3 years, were studied by random selection. The analysis was carried out in 2 groups of patients: patients who underwent COVID-19 in the period from January 2021 to March 2022 with a positive SARS-CoV-2 PCR result (n=36) and a control group of children who deny the disease (n=218). IgM and IgG were determined in blood serum samples by means of ELISA using the SARS CoV-2-IgM and SARS CoV-2-IgG quantitative diagnostic kits (Vector-Best, Novosibirsk, Russia). Results. In the group of children who did not have COVID-19, negative results were detected in 25.2% of cases. IgG antibodies specific to SARS-CoV-2 were detected in 74.8% of patients, of which a low level of virus-neutralizing activity was found in 15.6% of patients, an average level in 20.2% of cases, and a high level in 39.0% of cases. In the group of children who had the disease, a low level of virus-neutralizing activity was detected in 29.4%, an average level in 32.4%, and a high level of IgG antibodies to SARS-CoV-2 was detected in 38.2% of cases. In the group of children who underwent COVID-19, 77.8% of the disease proceeded with symptoms of acute respiratory viral infections, 22.2% had CT signs of pneumonia, and there were no significant differences in the levels of specific antibodies. In the group of children who underwent COVID-19, 77.8% of the disease proceeded with symptoms of acute respiratory viral infections, 22.2% had CT signs of pneumonia, and there were no significant differences in the levels of specific antibodies. Analysis of seroprevalence in dynamics after the disease showed that the highest level of antibodies persisted for 2-4 months. after an illness. Conclusion. The proportion of asymptomatic forms of infection among children and adolescents is quite high. These undocumented infections often go unrecognized due to mild or absence of symptoms and, depending on their contagiousness and number of contacts, may play a significant role in the transmission of SARS-CoV-2. The findings raise important questions that should be explored in further studies regarding the role of serological tests in assessing the true extent of SARS-CoV-2 exposure in pediatric populations, as well as monitoring the response and duration of SARS-CoV2 antibody-mediated immunity.

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SERPENCELESSNESS OF ANTIBODIES TO SARS-CoV-2 IN CHILDREN AGAINST THE BACKGROUND OF THE COVID-19 EPIDEMIC IN THE RUSSIAN FEDERATION

Cited by 3 publications

References 0 publications

Patterns in the development of collective immunity to SARS-CoV-2 during the COVID-19 pandemic

Patterns in the development of collective immunity to SARS-CoV-2 during the COVID-19 pandemic

Assessment of indicators of specific humoral immune against COVID-19 in children during the distribution of a new coronavirus infection in the Irkutsk region (2020–2021)

Assessment of the level of immune layer to SARS-CoV-2 in children under conditions of novel coronavirus infection COVID-19

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