Serous papillary adenocarcinoma of the female genital organs and invasive micropapillary carcinoma of the breast. Are WT1, CA125, and GCDFP-15 useful in differential diagnosis?

Moritani, Suzuko; Ichihara, Shu; Hasegawa, Masaki; Endo, Tokiko; Oiwa, Mikinao; Yoshikawa, Kunio; Sato, Yasuyuki; Aoyama, Hideaki; Hayashi, Takako; Kushima, Ryoji

doi:10.1016/j.humpath.2007.09.009

Cited by 52 publications

(22 citation statements)

References 23 publications

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“…In the Luyckx et al In our study MGB-1, and to a lesser extent GCDFP-15, seemed to be the most promising markers for the detection of breast cancer micrometastases (100% efficiency for MGB-1). These proteins are (over)expressed in the majority of breast cancer, explaining their potential interest as markers of breast cancer metastases (29)(30)(31), especially in ovarian tissue (32)(33)(34). Although MGB-1 expression was not detected in ovarian tissue samples from non-breast cancer patients, three of five samples from early breast cancer patients were positive for this marker.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of quantitative polymerase chain reaction markers for the detection of breast cancer cells in ovarian tissue stored for fertility preservation

Bockstaele

Boulenouar

Steen

et al. 2015

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Evaluation of quantitative polymerase chain reaction markers for the detection of breast cancer cells in ovarian tissue stored for fertility preservation

Bockstaele

Boulenouar

Steen

et al. 2015

Fertility and Sterility

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“…Other markers (e.g., GCDFP-15, mammaglobin, WT1, PAX8, and PAX2) might be useful and are under investigation [8,9]. GCDFP-15 is expressed by 38% of IMPCs and 0% of serous papillary adenocarcinomas [10]. Mammaglobin is expressed by 56% of IMPCs and 0% of ovarian serous papillary carcinomas [11].…”

Section: Discussionmentioning

confidence: 99%

“…Lee et al reported that the nuclear expression of WT1 was found in 24% of IMPCs, typically in less than 10% of cells, and that cytoplasmic staining has been seen 59% of IMPCs [13]. Moritani et al showed that the WT1 positivity rate in serous papillary adenocarcinomas was 78%, and the corresponding rate in IMPCs was 3% [10]. Thus, the presence of diffuse nuclear expression of WT1 strongly favors metastatic serous papillary ovarian or peritoneal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Primary peritoneal serous papillary carcinoma that metastasized to an axillary lymph node in a woman with a history of breast cancer: A case report and diagnostic pitfalls

Nomoto

Nakajima

Miwa

et al. 2015

Human Pathology: Case Reports

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Herein, we will report on a patient with primary peritoneal serous papillary carcinoma that metastasized to an axillary lymph node and who had previously undergone a mastectomy and chemotherapy for carcinoma of the right breast. A 40-year-old Japanese woman underwent partial resection of her left lung for metastatic breast cancer at our hospital. Thirteen years later, she developed a left axillary lymph node swelling, and a biopsy was performed. Histological findings were compatible with metastatic breast carcinoma. Positron emission tomography-computed tomography revealed systemic lymphadenopathy, peritoneal nodules, and a liver mass. The patient was diagnosed with recurrent breast cancer and underwent additional chemotherapy. Six months later, she developed ascites. She was diagnosed with serous adenocarcinoma using conventional and immunocytological examinations of the ascites. She underwent suboptimal debulking surgery, consisting of a total hysterectomy, bilateral oophorectomy, and partial omentectomy. The final pathological diagnosis was primary peritoneal serous papillary carcinoma.The diagnosis and pitfalls of this case will be presented.

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“…Increased MUC4 staining has a positive correlation with higher tumor grades [85,130,131], but it is unclear if this can be associated with patient prognosis [85]. MUC16 stained positive in invasive micropapillary carcinoma of the breast in one study, but its prognostic correlation was not examined [132]. …”

Section: Mucins In Cancermentioning

confidence: 99%

Transmembrane mucins as novel therapeutic targets

Constantinou

Danysh

Dharmaraj

et al. 2011

Expert Review of Endocrinology & Metabolism

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Membrane-tethered mucin glycoproteins are abundantly expressed at the apical surfaces of simple epithelia, where they play important roles in lubricating and protecting tissues from pathogens and enzymatic attack. Notable examples of these mucins are MUC1, MUC4 and MUC16 (also known as cancer antigen 125). In adenocarcinomas, apical mucin restriction is lost and overall expression is often highly increased. High-level mucin expression protects tumors from killing by the host immune system, as well as by chemotherapeutic agents, and affords protection from apoptosis. Mucin expression can increase as the result of gene duplication and/or in response to hormones, cytokines and growth factors prevalent in the tumor milieu. Rises in the normally low levels of mucin fragments in serum have been used as markers of disease, such as tumor burden, for many years. Currently, several approaches are being examined that target mucins for immunization or nanomedicine using mucin-specific antibodies.

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Serous papillary adenocarcinoma of the female genital organs and invasive micropapillary carcinoma of the breast. Are WT1, CA125, and GCDFP-15 useful in differential diagnosis?

Cited by 52 publications

References 23 publications

Evaluation of quantitative polymerase chain reaction markers for the detection of breast cancer cells in ovarian tissue stored for fertility preservation

Evaluation of quantitative polymerase chain reaction markers for the detection of breast cancer cells in ovarian tissue stored for fertility preservation

Primary peritoneal serous papillary carcinoma that metastasized to an axillary lymph node in a woman with a history of breast cancer: A case report and diagnostic pitfalls

Transmembrane mucins as novel therapeutic targets

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