Serous endometrial intraepithelial carcinoma (SEIC): Current clinical practice in The Netherlands

Slaager, Ciska; Hofhuis, Ward; Hoogduin, Klaas J.; Ewing‐Graham, Patricia C.; Beekhuizen, Heleen van

doi:10.1016/j.ejogrb.2021.08.012

Cited by 5 publications

(10 citation statements)

References 19 publications

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“…There are currently no reported factors enabling prediction of the SEIC. Occurrence of metastases in cases of SEICs is a welldocumented phenomenon although no definite mechanism could be established [4] . Cases of metachronous metastasis of SEIC have been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Many hypotheses exist trying to explain occurrence of metastases in cases of SEIC. Among these, dissemination through migration of superficial detached neoplastic cells remains the most http://jmscr.igmpublication.org/home/ ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v11i3.14 acceptable [4] . Pathological assessment of cases of SEIC finds the same neoplastic cells as in cases of invasive serous endometrial carcinoma [4] .…”

Section: Introductionmentioning

confidence: 99%

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Serous endometrial intraepithelial carcinoma (SEIC) with metachronous umbilical cutaneous, pleural, and peritoneal metastases: Case report and literature review

2023

jmscr

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Serous endometrial intraepithelial carcinoma is most often confined to the uterus, having consequently a favorable prognosis. However, and although this lesion remains limited to the epithelium with no stromal invasion, many cases of extrauterine spread have been reported at time of diagnosis or in a metachronous way. In this work we report the case of a 58-years-old menopausal female with pure serous endometrial intraepithelial carcinoma revealed by vaginal bleeding and pelvic pain with no metastases at exploration. She has undergone total hysterectomy, bilateral salpingo-oophorectomy and bilateral iliac lymph nodes dissection. Six months later, the patient presented with metachronous pleural, peritoneal and cutaneous metastases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serous endometrial intraepithelial carcinoma (SEIC) with metachronous umbilical cutaneous, pleural, and peritoneal metastases: Case report and literature review

2023

jmscr

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“…Several studies suggest that superficial intraepithelial carcinoma may spread through the tubes or lymphatic vessels within the peritoneal cavity. However, its behavior is currently unpredictable [4]. Although there are no International guidelines, the WHO recommends surgical staging of the disease (hysterectomy, bilateral salpingo-oophorectomy, omentectomy, lymph node removal, or peritoneal dissection and biopsy).…”

Section: Introductionmentioning

confidence: 99%

“…The scarcity with which it occurs and the variable prognosis reported in the literature mean that there is no non-ambiguous adjuvant therapy. Data are available in the literature on the use of chemotherapy and on follow-up models [4][5][6]. The purpose of this review is to investigate the effects of adjuvant treatments on the prognosis of the disease.…”

Section: Introductionmentioning

confidence: 99%

Critical Overview of Serous Endometrial Intraepithelial Cancer Treatment: Systematic Review of Adjuvant Options

Ronsini,

Reino,

Molitierno

et al. 2023

Life

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SEIC is a non-invasive lesion of the endometrial epithelium considered to be the precursor to uterine serous carcinoma (USC) and is just as aggressive as USC. Currently, there are no reliable data about the behavior and prognosis of SEIC; therefore, the therapeutic management approach is not clear. Method: A systematic search of the Pubmed, Scopus and Embase databases was conducted, following the recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Results: Of the 296 studies that matched the search criteria, only 9 met the inclusion criteria, covering a total of 81 patients. The main disease-presenting pattern was AUB (abnormal uterine bleeding). In 31 cases, SEIC was associated with extrauterine disease. All patients underwent hysterectomy and salpingo-oophorectomy, while only 15 of the 81 patients received adjuvant treatments. In the patients receiving adjuvant therapy, the RR was 42.67%, the DFS was 35.71% and the OS was 57.13%. In patients subjected to follow-up alone, the RR was only 28.78%, the DFS was 59.1% and the OS was 66.6%. Conclusions: The presence of an extrauterine disease significantly worsens outcomes, regardless of adjuvant treatment. In cases of disease confined to the uterine mucosa alone, the prognosis is good and follow-up allows a good control of the disease; however, adjuvant therapy could further increase survival rates and reduce relapse rates.

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“…Clinicians may still be uncertain what type of surgery to perform and whether adjuvant therapy should be administered. In our previously published survey on management of serous endometrial intra-epithelial carcinoma among Dutch gynecological oncologists, this uncertainty was illustrated, showing a broad spectrum of approaches, ranging from a limited hysteroscopic resection of the polyp to surgical staging 22…”

Section: Introductionmentioning

confidence: 99%

Serous endometrial intra-epithelial carcinoma: an observational study

Slaager

Hofhuis

Hoogduin³

et al. 2023

Int J Gynecol Cancer

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BackgroundSerous endometrial intra-epithelial carcinoma is described as a malignant, superficial spreading lesion with risk of extra-uterine spread at time of diagnosis, and poor outcome.ObjectiveTo evaluate the surgical management of patients with serous endometrial intra-epithelial carcinoma and its impact on oncologic outcomes and complications.MethodsThis Dutch observational retrospective cohort study evaluated all patients diagnosed with pure serous endometrial intra-epithelial carcinoma in the Netherlands, between January 2012 and July 2020. The pathological examination was reviewed by two pathologists with expertise in gynecological oncology. Clinical data were obtained when the diagnosis was confirmed. Primary outcome is progression-free survival, secondary outcomes are duration of follow-up, adverse events related to surgery, and overall survival.ResultsA total of 23 patients from 13 medical centers were included, of whom 15 (65.2%) presented with post-menopausal blood loss. In 17 patients (73.9%) the intra-epithelial lesion was present in an endometrial polyp. All patients underwent hysterectomy, of whom 12 patients (52.2%) were surgically staged. None of the staged patients showed extra-uterine disease. Two patients received adjuvant brachytherapy. There were no recurrences of disease (median follow-up duration of 35.6 months (range 1.0–108.6) and no disease-related deaths in this cohort.ConclusionIn patients with serous endometrial intra-epithelial carcinoma, median progression-free survival reached nearly 3 years and no recurrences have been reported. Our results do not endorse World Health Organization 2014 advice to treat serous endometrial intra-epithelial carcinoma as high-grade, high-risk endometrial carcinoma. Full surgical staging might possibly lead to overtreatment.

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Serous endometrial intraepithelial carcinoma (SEIC): Current clinical practice in The Netherlands

Cited by 5 publications

References 19 publications

Serous endometrial intraepithelial carcinoma (SEIC) with metachronous umbilical cutaneous, pleural, and peritoneal metastases: Case report and literature review

Serous endometrial intraepithelial carcinoma (SEIC) with metachronous umbilical cutaneous, pleural, and peritoneal metastases: Case report and literature review

Critical Overview of Serous Endometrial Intraepithelial Cancer Treatment: Systematic Review of Adjuvant Options

Serous endometrial intra-epithelial carcinoma: an observational study

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