Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects

Hyriavenko, Nataliia Ivanivna; Lyndin, Mykola Serhiiovych; Sikora, Kateryna; Piddubnyi, Artem; Karpenko, Ludmila; Kravtsova, O. I.; Hyriavenko, Dmytrii; Diachenko, Olena; Sikora, Vladyslav; Романюк, Анатолий Николаевич

doi:10.4132/jptm.2019.03.21

Cited by 11 publications

(13 citation statements)

References 23 publications

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“…In the course of the study, data were obtained that could help in the diagnosis, selection of adequate therapy for gynecological diseases. In addition, this study can be used for the timely diagnosis of conditions that threaten the life of women (bleeding, rupture of cysts) and even malignant neoplasms [31][32][33][34][35], which is intended to reduce the percentage of mortality or disability among this group of patients.…”

Section: T H E O R E T I C a L And E X P E R I M E N Tal M E D I C I N Ementioning

confidence: 99%

Features of Endometrium Structure in Alcohol-Abusing Hiv-Infected Individuals

Lytvynenko

2021

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Background. Patients with comorbid pathology occupy leading positions in the practice of a doctor of any specialty especially in patients with HIV. Reproductive system is known to be the gateway for viruses. This fact could explain the severity of changes developing in the female reproductive system infected with HIV, in particular in the endometrium. The purpose of this study was to assess morphological changes in the endometrium caused by the combined effects of HIV infection and chronic alcoholism. Materials and methods: The study included sectional material taken from 60 women of reproductive age (20-40 years). They were all divided into two groups. The first group (30 people) consisted of HIV-positive individuals who, according to a survey of relatives and according to an autopsy (the main symptom is the presence of alcoholic cirrhosis of the liver), alcohol abuse was confirmed. The following parameters were determined: the average diameter of the endometrial glands (proliferative type), the minimum diameter of the endometrial glands (proliferative type), the maximum diameter of the endometrial glands (proliferative type), wall thickness (proliferative type), the relative volume of the epithelium (proliferative type), the average diameter of the glands (secretory type), the minimum diameter of the glands (secretory type), the maximum diameter of the glands (secretory type), the relative volume of the epithelium (secretory type), the thickness of the epithelium. Results. the average diameter of the endometrial glands (proliferative type) decreased from 51.71 ± 2.90 x 10-6 m in the comparison group to 39.42 ± 2.35 x 10-6 m in the HIV-infected group, which was 23.77%. The minimum diameter of the endometrial glands (proliferative type) reduced from 32.47 ± 1.83 x10-6 m to 27.13 ± 1.73x10-6 m (16.45%), the maximum diameter from 72.14 ± 2.21 x10-6 m to 63.84 ± 3.29 x10-6 m (11.5%). the relative volume of the epithelium (proliferative type) decreased by 5.41% (from 54.43 ± 1.79% in the study group to 49.02 ± 2.65% in the control group). The thickness of the uterine wall was also significantly reduced from 15.18 ± 1.60 x10-6 m to 14.52 ± 1.19 x10-6 m, which was 4.35%. The maximum volume of glands (secretory type) changed from 127.98 ± 2.10 x10-6 m to 97.18 ± 3.12 x10-6 m (24%). Changes by 3.6% were also observed when examining the wall thickness (from 13.02 ± 1.36 x10-6 m to 12.55 ± 1.68 x10-6 m). Conclusion. The study evaluated features of endometrial restructuring in alcohol-abusing HIV-infected women.

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Section: T H E O R E T I C a L And E X P E R I M E N Tal M E D I C I N Ementioning

confidence: 99%

Features of Endometrium Structure in Alcohol-Abusing Hiv-Infected Individuals

Lytvynenko

2021

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“…Первинний рак маткових труб (РМТ) є рідкісним і складним для діагностики захворюванням. Згідно з більшістю публікацій і нашими спостереженнями, РМТ становить 1,3-1,9% раку жіночих статевих органів і не менше 4-6% раку придатків матки [1][2][3]. Крім того, епідеміологічні дослідження відзначають зростання захворюваності на РМТ, наприклад, з 2001 по 2014 рік їхня кількість зросла до 4 разів [4,5].…”

Section: вступunclassified

“…Крім того, епідеміологічні дослідження відзначають зростання захворюваності на РМТ, наприклад, з 2001 по 2014 рік їхня кількість зросла до 4 разів [4,5]. До теперішнього часу достовірні діагнози до операції при РМТ коливаються від 0 до 10-15% [1,3,6]. Одні автори продовжують вважати цей діагноз операційною знахідкою, інші -швидше патологоанатомічним, ніж клінічним [6,7].…”

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Problems of primary fallopian tube cancer diagnostics during and after surgery

Сумцов¹,

Гладчук

Sumtsov

et al. 2021

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To date, the reliable diagnoses primary fallopian tube cancer (PFTC) before surgery range from 0% to 10–15%. Number of misdiagnosis even during operations reaches 30–50% and PFTC is often disguised as innocent hydro-hematosalpinx or other diseases.Research objective: to study the possibilities of PFTC diagnosis during laparotomy and laparoscopy, macroscopic examination of removed macrodrugs, suboperative use of morphological studies, problems of histological interpretation of PFTC after surgery.Materials and methods. During the period from 1966 to 2020 authors of article selected and retrospectively studied quite informative medical histories of 105 patients with PFTC aged 34 to 78 years (mean age 55.8 years). All patients were operated. Revision of the pelvic organs and abdominal cavity was performed during operations. Removed macrodrugs were examined macroscopically and histologically. According to the indications during operations histological and cytological methods of rapid diagnosis were used. Immunohistochemical methods were used to interpret rare and difficult to diagnose tumors after surgery.Results. Only 7 (6.6%) from 105 patients with PFTC was not recognized during surgery, and 18 (17.1%) were diagnosed only after suboperative histological examination. Errors during operations in the initial PFTC forms (without careful study of macrodrugs and suboperative morphological examination) can reach 23.8%. Problems with the primary lession interpretation, which arose in 11 (10.5%) patients with a pronounced tumor process, did not prevent the choice of adequate surgery. The tumor dissemination of the fallopian tube outside was detected in 69 (72.4%) patients, in 25 (26.2%) among them there were lymph node metastases.Conclusion. Careful revision of the abdominal organs and macroscopic examination of removed drugs using suboperative morphological studies avoids errors in the diagnosis and surgical treatment of patients with PFTC.

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“…[4] Though primary fallopian tube malignancy is rare, it has a high mortality rate and also are now linked with the pathogenesis of serous epithelial tumors of the ovary. [5] This has led to the current practice of extensive sampling of the fallopian tube as compared to before by Sectioning and Extensively Examining the FIMbriated End (SEE-FIM) protocol. [6] With the increase in sampling of fallopian tube specimen, it may be common to encounter artefactual changes caused by heat from cautery used in surgery and may cause confusion among young budding pathologists.…”

Section: Dear Sirmentioning

confidence: 99%