Serotyping for Homotransplantation. Ix. Evaluation of Leukocyte Antigen Matching With the Clinical Course and Rejection Types

Hm, Lee; Dm, Hume; Dl, Vredevoe; Mr, Mickey; Pi, Terasaki

doi:10.1097/00007890-196707001-00038

Cited by 28 publications

(12 citation statements)

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“…There is little doubt as to the importance of HL-A matching of leukocytes and the success of organ transplantation, as shown by this (2), and other laboratories (3)(4)(5)(6)(7). Some well-matched recipients, however, have rejected kidneys, whereas other poorly-matched recipients have experienced no or only minor rejections.…”

Section: Introductionmentioning

confidence: 83%

Comparison of the HL-A phenotypes of lymphocytes and kidney cells determined by the fluorochromasia cytotoxicity assay

Douglas¹,

Perkins²,

Cochrum³

et al. 1971

J. Clin. Invest.

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A B S T R A C T Correlation of leukocyte typing with homograft survival suggests that HL-A typing of white blood cells reflects the histocompatibility factors of the kidney, yet some apparently well-matched kidneys are rejected. The latter results may, in part, reflect inadequacies of typing techniques, incomplete expression of HL-A factors on white blood cells as compared with the cells of the rejected organ, or isoantigens not shared with leukocytes.In this study the kidney cells and lymphocytes (from blood or nodes) of 14 individuals were typed for HL-A factors 1, 2, 3, 5, 7, 8, 9, and 12, and factors 4a and 4b by fluorochromasia cytotoxicity. Biopsied kidney cells were prepared with 0.25% trypsin and typed fresh, after varying periods in monolayer culture or after storage in liquid nitrogen, in all cases resulting in cells which were pleomorphic but uniform in reactivity.Reproducibility of lymphocyte typing was 99%, and of kidney cell typing, 93%. The 4a factor was detected on the lymphocytes but not the kidney cells of four individuals. HL-A7 and HL-A8, in contrast, were detected on kidney cells and not lymphocytes of four and three individuals, respectively. Results were consistent within the groups of individual sera used to detect each factor. The HL-A factors detected on both kidney cells and lymphocytes never resulted in more than two alleles at each genetic sublocus.

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Section: Introductionmentioning

confidence: 83%

Comparison of the HL-A phenotypes of lymphocytes and kidney cells determined by the fluorochromasia cytotoxicity assay

Douglas¹,

Perkins²,

Cochrum³

et al. 1971

J. Clin. Invest.

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“…Analysis by the Terasaki matching technique [7] did not indicate any predictive value of the HL-A groups. Table III gives the data.…”

Section: Correlation Of Hl-a Groups With Outcomementioning

confidence: 76%

A Shared HL-A Haplotype Seems to Make a Cadaver Donor Satisfactory for Kidney Transplantation

Fotino¹,

Allen²

1972

Vox Sanguinis

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Genetically related donor-recipient kidney transplant pairs who share 1 HL-A haplotype have a high incidence of successful outcome. We present evidence that unrelated pairs who appear to be possible sharers of an HL-A haplotype also are satisfactory. Although there is some uncertainty, in an unrelated pair, whether they do, in fact, share an HL-A haplotype, because there are usually alternative possibilities, the probabilities usually favor that they do share a haplotype.

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“…Rejections are common during the first three months after transplantation and require large doses of immunosuppressive drugs for their control (Lee et al, 1967). As a result serious complications, including death of the patient, often develop in relation to a rejection episode (Starzl, 1964).…”

Section: Introductionmentioning

confidence: 99%

Value of Prospective Tissue Typing in Kidney Transplantation Between HL-A Identical Siblings

Patel¹,

Myrberg²

1970

BMJ

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Serotyping for Homotransplantation. Ix. Evaluation of Leukocyte Antigen Matching With the Clinical Course and Rejection Types

Cited by 28 publications

References 0 publications

Comparison of the HL-A phenotypes of lymphocytes and kidney cells determined by the fluorochromasia cytotoxicity assay

Comparison of the HL-A phenotypes of lymphocytes and kidney cells determined by the fluorochromasia cytotoxicity assay

A Shared HL-A Haplotype Seems to Make a Cadaver Donor Satisfactory for Kidney Transplantation

Value of Prospective Tissue Typing in Kidney Transplantation Between HL-A Identical Siblings

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