Serotype-specific antibody responses of calves infected naturally with bovine rotavirus.

Murakami, Yosuke; Nishioka, Nobuyoshi; Eguchi, Masashi; Kuniyasu, C

doi:10.1292/jvms1939.52.171

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“…Serological analyses of calves naturally or experimentally infected with bovine rotaviruses revealed the presence of serotype-specific antibody responses and failure of cross-protection between distinct serotypes [22,23]. On the other hand, the presence of complex antigenic relationships as suggested by one-way heterotypic cross-protection among bovine rotavirus strains have been observed in challenge experiments with strains belonging to two different G types [35,36].…”

Section: Discussionmentioning

confidence: 99%

Presence of three P types (VP4 serotypes) and two G types (VP7 serotypes) among bovine rotavirus strains

Matsuda

Nakagomi

Offit

1990

Archives of Virology

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Cross neutralization tests with a panel of rotavirus strains representing previously described nine VP7 (G) serotypes revealed that bovine rotavirus strain KK-3, a prototype Japanese bovine serotype 2, belonged to a new serotype (G10), confirming and extending the recent report of Snodgrass et al. [J. Clin. Microbiol. 28: 504-507 (1990)] which showed that hyperimmune serum to the KK-3 strain neutralized the B223 strain, a proposed type strain of G10. Further antigenic characteristics of the KK-3 strain, as well as the 0510 strain (a G6 strain isolated in Japan), were examined in terms of their VP4 (P) specificity. For the characterization of P types, we employed genetic reassortants that possess VP4 gene for UK and VP7 gene for D (G1), VP4 gene for NCDV and VP7 gene for SA11 (G3), or VP4 gene for SA11 and VP7 gene for NCDV (G6) in the plaque reduction neutralization assay with hyperimmune sera against these two Japanese strains and the prototype bovine rotavirus NCDV strain. While the 0510 strain had UK-like P and NCDV-like G types, the KK-3 strain had a distinct set of P and G types. Thus, at least three P types (NCDV-, UK-, and KK-3-like) and two G types (G6 and G10) are present among bovine rotavirus strains.

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Section: Discussionmentioning

confidence: 99%