Serotype-Specific Anti-Pneumococcal IgG and Immune Competence: Critical Differences in Interpretation Criteria When Different Methods are Used

Balloch, Anne; Licciardi, Paul V.; Tang, Mimi L.K.

doi:10.1007/s10875-012-9806-9

Cited by 30 publications

(21 citation statements)

References 28 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Quantitative comparisons of PnAb levels measured by multiplex assays were not always consistent with results from WHO-based ELISA methods (15), and the performance characteristics of these assays often did not meet the criteria set in the original WHO document developed for ELISA testing. Intralaboratory comparisons of assays from different laboratories showed substantial variation in quantitative results even when the same basic technology was being utilized (16), although clinical classifications of patients were relatively unaffected by these quantitative variations using published algorithms (17,18).…”

Section: Multiplex Assaysmentioning

confidence: 94%

Use and Clinical Interpretation of Pneumococcal Antibody Measurements in the Evaluation of Humoral Immune Function

Daly

Hill

2014

Clin. Vaccine Immunol.

View full text Add to dashboard Cite

Pneumococcal vaccination is a commonly used technique for assessing the humoral immune status of a patient suspected of having immunodeficiency. Interpretation of what constitutes an adequate response, however, can be challenging. This is due to the complexity of the data generated from serotype-specific assays, historical variations in the assays used to measure pneumococcal antibodies, and varying recommendations on the relevant cut points that define response. In this review, we summarize the historical evolution of assays used for this purpose and discuss the analytical considerations that have influenced published data. We also examine current clinical recommendations for defining an adequate response to vaccination, with a particular focus on the interpretation of serotype-specific data generated by multiplex assays.

show abstract

Section: Multiplex Assaysmentioning

confidence: 94%

Use and Clinical Interpretation of Pneumococcal Antibody Measurements in the Evaluation of Humoral Immune Function

Daly

Hill

2014

Clin. Vaccine Immunol.

View full text Add to dashboard Cite

show abstract

“…Comparison of laboratories performing the WHO ELIZA show considerable variability in results [36]. The results from the WHO ELIZA cannot be compared with other commercially available assays, including the xMAP kit used on the Luminex platform [37]. Opsonophagocytic function has been measured in research laboratories, but is beyond the capability of most routine diagnostic laboratories [38,39].…”

Section: Critical Analysis Of the Esid/pagid Criteria For Cvidmentioning

confidence: 99%

New diagnostic criteria for common variable immune deficiency (CVID), which may assist with decisions to treat with intravenous or subcutaneous immunoglobulin

Ameratunga

Woon

Gillis

et al. 2013

Clinical and Experimental Immunology

197

196

View full text Add to dashboard Cite

SummaryCommon variable immune deficiency (CVID) is the most frequent symptomatic primary immune deficiency in adults. The standard of care is intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (scIG) therapy. The cause of CVID is currently unknown, and there is no universally accepted definition of CVID. This creates problems in determining which patients will benefit from IVIG/scIG treatment. In this paper, we review the difficulties with the commonly used European Society of Immune Deficiencies (ESID) and the Pan American Group for Immune Deficiency (PAGID) definition of CVID. We propose new criteria for the diagnosis of CVID, which are based on recent scientific discoveries. Improved diagnostic precision will assist with treatment decisions including IVIG/ scIG replacement. We suggest that asymptomatic patients with mild hypogammaglobulinaemia are termed hypogammaglobulinaemia of uncertain significance (HGUS). These patients require long-term follow-up, as some will evolve into CVID.

show abstract

“…This technique increases specificity by removing nonspecific antibodies. [16][17][18] Commercial laboratories have now adopted measurement of specific antibodies using Luminex. Results with this test vary from those obtained by ELISA.…”

Section: Specific Antibody Deficienciesmentioning

confidence: 99%

Specific Antibody Deficiencies

Dimitriades

Sorensen

2015

Immunology and Allergy Clinics of North America

View full text Add to dashboard Cite

Serotype-Specific Anti-Pneumococcal IgG and Immune Competence: Critical Differences in Interpretation Criteria When Different Methods are Used

Cited by 30 publications

References 28 publications

Use and Clinical Interpretation of Pneumococcal Antibody Measurements in the Evaluation of Humoral Immune Function

Use and Clinical Interpretation of Pneumococcal Antibody Measurements in the Evaluation of Humoral Immune Function

New diagnostic criteria for common variable immune deficiency (CVID), which may assist with decisions to treat with intravenous or subcutaneous immunoglobulin

Specific Antibody Deficiencies

Contact Info

Product

Resources

About