Serotype, Genotype, and Clinical Manifestations of Group B Streptococcus (GBS) Isolated from Neonates in China

Wang, Shaohua; Li, Li; Wu, Benqing; Wu, Weiyuan

doi:10.5812/ijp.14580

Cited by 2 publications

(2 citation statements)

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“…This study showed that respiratory distress occurred more frequently in patients with serotype Ia and Ib disease, whereas purulent meningitis was more related to serotype III. It has previously been reported that 86.2% of meningitis cases and 60.8% of sepsis cases were caused by serotype III GBS isolates in European countries and the United States [16]. Our data also demonstrated that meningitis was dominant in LOD cases compared to EOD cases, and that serotype III was the most prevalent serotype that induced meningitis in LOD cases, in agreement with a previous study [17].…”

Section: Discussionsupporting

confidence: 93%

Etiological serotype and genotype distributions and clinical characteristics of group B streptococcus-inducing invasive disease among infants in South China

Zhu¹,

Wu²,

Zheng³

et al. 2020

BMC Pediatr

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Background: Group B streptococcus (GBS)-induced invasive disease is a major cause of illness and death among infants aged under 90 days in China; however, invasive GBS infection remains unknown in China. We aimed to describe the serotype and genotype distributions of early-onset disease (EOD) and late-onset disease (LOD), and to show the clinical correlations among various GBS serotypes and genotypes obtained from infants with invasive GBS infections. Methods: Between June 1, 2016 and June 1, 2018, 84 GBS strains were collected from patients younger than 90 days at seven Chinese hospitals. Clinical data were retrospectively reviewed. GBS serotyping was conducted and multi-locus sequence typing was performed. Results: Serotypes Ia, Ib, II, III, and V were detected. Serotype III (60.71%) was the most common, followed by Ia (16.67%) and Ib (14.29%). Intrapartum temperature ≥ 37.5°C, chorioamnionitis, and mortality were noted in 28.57, 42.86, and 28.57% of patients with serotype Ia, respectively, and these rates were higher than those in patients with serotypes Ib and III (P = 0.041, P = 0.031, and P = 0.023, respectively). The incidence of respiratory distress was lower (P = 0.039) while that of purulent meningitis was higher (P = 0.026) in the serotype III group. Eighteen sequence types were detected among isolates, and ST17 [42.86% (36/84)] was the most prevalent. Conclusions: GBS isolates belonging to serotypes Ia, Ib, and III are common in southern mainland China, and ST17 is highly prevalent. Differences were found in the clinical manifestations of invasive GBS disease induced by serotypes Ia and III.

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Section: Discussionsupporting

confidence: 93%

Etiological serotype and genotype distributions and clinical characteristics of group B streptococcus-inducing invasive disease among infants in South China

Zhu¹,

Wu²,

Zheng³

et al. 2020

BMC Pediatr

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“…However, the erythromycin resistance rate among GBS isolates in the present study was relatively higher when compared with other studies in Iran, 34 35 36 but the high rates of resistance to erythromycin in GBS were reported in China (92.5% and 84.6%), Iraq (58.6%) and the USA (50.7%). 37 38 39 40 Furthermore, high resistance rates of GBS strains to clindamycin were reported from Iran (92.2%) and other countries such as China (55.7% and 87.5%), Iraq (45.6%) and Italy (32.20%). 19 37 39 41 It is noteworthy that the high rate of erythromycin and clindamycin resistance in GBS strongly supports the CDC recommendations for susceptibility testing of GBS isolates before initiating prophylaxis with erythromycin or clindamycin.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Susceptibility Patterns and Prevalence of Streptococcus Agalactiae Rectovaginal Colonization Among Pregnant Women in Iran

Dashtizade

Zolfaghari

Yousefi

et al. 2020

Rev Bras Ginecol Obstet

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Objective Streptococcus agalactiae is an important pathogen in neonates and pregnant women. Neonatal invasive infections due to S. agalactiae are life-threatening and preventive strategies for this challenge of human have become a concern. The aim of the present study was to determine the prevalence of rectovaginal colonization, related risk factors and antibiotic resistance pattern of S. agalactiae among pregnant women in Iran. Methods The present study was performed on 240 pregnant women. Vaginal and rectal swabs were obtained from all of the women and then were transferred to the laboratory. The isolation and identification of S. agalactiae was performed by standard microbiological tests and polymerase chain reaction (PCR) assay. The antimicrobial susceptibility patterns of the isolates were determined by the Kirby-Bauer disk diffusion. Polymerase chain reaction was used to detect ermB and mefA genes in erythromycin-nonsusceptible isolates. Results Out of 240 pregnant women, 16 cases (6.7%) were colonized by S. agalactiae. There is no significant association between demographic-obstetric factors and maternal S. agalactiae colonization in the pregnant women. Linezolid, vancomycin and ampicillin were the most effective antibiotics against S. agalactiae. The ermB gene was present in 6 (35.29%) S. agalactiae isolates. However, the mefA gene was not detected in any of the isolates. Conclusion Given the relatively significant prevalence of S. agalactiae colonization in the pregnant women in the present study and the risk of serious neonatal infections, the screening of pregnant mothers for the bacteria seems necessary. Our findings highlight the importance of appropriate antibiotic prophylaxis during pregnancy for the prevention of early onset S. agalactiae-neonatal infection and comorbidity.

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Serotype, Genotype, and Clinical Manifestations of Group B Streptococcus (GBS) Isolated from Neonates in China

Cited by 2 publications

References 20 publications

Etiological serotype and genotype distributions and clinical characteristics of group B streptococcus-inducing invasive disease among infants in South China

Etiological serotype and genotype distributions and clinical characteristics of group B streptococcus-inducing invasive disease among infants in South China

Antibiotic Susceptibility Patterns and Prevalence of Streptococcus Agalactiae Rectovaginal Colonization Among Pregnant Women in Iran

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