Serotype distribution and antimicrobial profile of Streptococcus pneumoniae isolated from adult patients with community-acquired pneumonia in Jakarta, Indonesia

Amanda, Gina; Tafroji, Wisnu; Sutoyo, Dianiati Kusumo; Burhan, Erlina; Haryanto, Budi; Safari, Dodi

doi:10.1016/j.jmii.2020.10.003

Cited by 8 publications

(8 citation statements)

References 9 publications

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“…IPD is the invasive form of pneumococcal infection and only a small proportion of patients infected with S. pneumoniae progress to IPD [36] . Because of the high CFR of IPD, surveillance of isolates from IPD is conducted in most countries, but not for isolates of S. pneumoniae causing only pneumonia that cause higher mortality than IPD.…”

Section: Discussionmentioning

confidence: 99%

National surveillance of antimicrobial susceptibilities to dalbavancin, telavancin, tedizolid, eravacycline, omadacycline and other comparator antibiotics and serotype distribution of invasive Streptococcus pneumoniae isolates in adults: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) programme in 2017–2020

Chien

Lee

Liu

et al. 2021

Journal of Global Antimicrobial Resistance

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Objectives The aim of this study was to investigate the trends in serotypes and in vitro antimicrobial susceptibility of Streptococcus pneumoniae causing adult invasive pneumococcal disease (IPD) to dalbavancin, telavancin, tedizolid, eravacycline, omadacycline and other comparator antibiotics from 2017–2020 following implementation of the 13-valent pneumococcal conjugate vaccine (PCV-13) and during the COVID-19 (coronavirus disease 2019) pandemic. Methods During the study period, 237 S. pneumoniae isolates were collected from non-duplicate patients, covering 15.0% of IPD cases in Taiwan. Antimicrobial susceptibility testing was performed using a Sensititre® system. A latex agglutination method (ImmuLex™ Pneumotest Kit) was used to determine serotypes. Results Susceptibility rates were high for vancomycin (100%), teicoplanin (100%) and linezolid (100%), followed by ceftaroline (non-meningitis) (98.3%), moxifloxacin (94.9%) and quinupristin/dalfopristin (89.9%). MIC 50 and MIC 90 values of dalbavancin, telavancin, tedizolid, eravacycline and omadacycline were generally low. Non-vaccine serotype 23A was the leading cause of IPD across the adult age range. Isolates of serotype 15B were slightly fewer than those of PCV-13 serotypes in patients aged ≥65 years. The overall case fatality rate was 15.2% (36/237) but was especially high for non-PCV-13 serotype 15B (21.4%; 3/14). Vaccine coverage was 44.7% for PCV-13 and 49.4% for the 23-valent pneumococcal polysaccharide vaccine (PPSV-23), but was 57% for both PCV-13 and PPSV-23. Conclusion The incidence of IPD was stationary after PCV-13 introduction and only dramatically decreased in the COVID-19 pandemic in 2020. The MIC 50 and MIC 90 values of dalbavancin, telavancin, tedizolid, eravacycline, omadacycline were generally low for S. pneumoniae causing adult IPD.

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Section: Discussionmentioning

confidence: 99%

National surveillance of antimicrobial susceptibilities to dalbavancin, telavancin, tedizolid, eravacycline, omadacycline and other comparator antibiotics and serotype distribution of invasive Streptococcus pneumoniae isolates in adults: results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) programme in 2017–2020

Chien

Lee

Liu

et al. 2021

Journal of Global Antimicrobial Resistance

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“…Among 42 % of vaccine serotypes found in this study, we identified serotype three as one of prevalent serotypes which was previously reported as a common serotype found among adult patients with community-acquired pneumonia in Jakarta, Indonesia [ 20 ]. Vaccine serotypes including serotype 3, 7F, 19A, 1, and 14 were reported as the most frequent serotypes found in adult patients with invasive pneumococcal disease in Portugal before PCV13 [ 21 ].…”

Section: Discussionmentioning

confidence: 65%

Nasopharyngeal carriage rate, serotype distribution, and antimicrobial profiles of Streptococcus pneumoniae among patients with acute respiratory tract infection in Manado, North Sulawesi, Indonesia

Purwanto,

Khoeri,

Tafroji

et al. 2024

Access Microbiology

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We studied the carriage rate, distribution of serotype, and antimicrobial profile of Streptococcus pneumoniae (S. pneumoniae) among patients with acute respiratory tract infections (ARTI) in two primary health centres and a tertiary referral hospital from 2019 to 2020 in Manado, North Sulawesi, Indonesia before 13-valent pneumococcal conjugate vaccine (PCV13) introduction. A total of 106 nasopharyngeal swab samples were collected from children and adult patients. Serotyping of S. pneumoniae strain was performed by sequential multiplex PCR and Quellung reaction. Antimicrobial profile was performed by the disc diffusion method. We identified thirty-one patients carried S. pneumoniae strains (29 %). The S. pneumoniae carriage rate was found to be higher among children aged 2–5 years (13/32; 40.6 %) than in children under 1 year (8/27; 29.6 %), children and adolescents under 18 years of age (5/20; 25.0 %) and adult patients (5/27; 18.5 %). The distribution of serotypes varied, including 14, 18C, 19A, 23F, 19F and 35B (two strains each) and 1, 3, 6B, 6C, 31, 9V, 15C, 16F, 17F, 23A, 35F (one strain each) and non-typeable (9/31; 29 %). We found S. pneumoniae isolates were susceptible to vancomycin (30/31; 97 %), chloramphenicol (29/31; 94 %), clindamycin (29/31; 94 %), erythromycin (22/31; 71 %), azithromycin (22/31; 71 %), tetracycline (14/31; 45 %), penicillin (11/31; 35 %), and sulfamethoxazole/trimethoprim (10/31; 32 %). This study provides supporting baseline data on distribution of serotype and antimicrobial profile of S. pneumoniae among patients with ARTI before PCV13 introduction in Manado, North Sulawesi, Indonesia.

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“…These isolates were obtained from blood ( n = 14), pleural fluid ( n = 6), cerebrospinal fluid ( n = 9), bronchoalveolar lavage fluid ( n = 1), sputum ( n = 7) and nasopharyngeal swab specimens ( n = 45). The isolates were obtained from Banjarmasin ( n = 4), Kotabaru ( n = 9), Medan ( n = 6), Surabaya ( n = 34), Semarang ( n = 10), Jakarta ( n = 10), Lombok ( n = 3), Makasar ( n = 13), and Manado ( n = 5), Indonesia as reported previously [5] , [6] , [7] , [8] . All isolates were collected from 2012 to 2019.…”

Section: Data Descriptionmentioning

confidence: 96%