Serotonin type-3 receptors differentially modulate anxiety and aggression during withdrawal from adolescent anabolic steroid exposure

Morrison, Thomas R.; Ricci, Lesley A.; Puckett, Amanda S.; Joyce, Jillian L.; Curran, Riley; Davis, Courtney R.; Melloni, Richard H.

doi:10.1016/j.yhbeh.2019.104650

Cited by 10 publications

(7 citation statements)

References 87 publications

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“…These results seem to suggest that treadmill exercise training might induce more positive effects in emotionality and exploration-related domains than in cognitive areas such as memory. Several brain neurotransmitter systems, including serotonergic [ 53 ], GABAergic [ 54 ], and glutamatergic systems [ 55 ] are involved in controlling anxiety-related behaviors and it has been demonstrated that modulations in serotonergic, noradrenergic, and GABAergic neurotransmission may be involved in anxiolytic effects of exercise [ 56 ]. On the other hand, in our study, treadmill exercise did not reduce binge alcohol consumption over time ( Figure 2 a), which has also been observed in other studies in which voluntary wheel running seemed to have a more positive effect on other patterns of alcohol drinking [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice

et al. 2020

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The binge-drinking pattern of EtOH consumption, which is frequently observed in adolescents, is known to induce several neurobehavioral alterations, but protection strategies against these impairments remain scarcely explored. We aimed to study the protective role of treadmill physical exercise on the deficits caused after repeated cycles of binge-like EtOH exposure in the cognition, motivation, exploration, and emotion of C57BL/6J mice from adolescence to adulthood. Animals were divided into four groups: control group, exercised group, EtOH group, and exercised + EtOH group (20% in tap water). The exercise was performed for 20 min, 5 days/week at 20 cm/s. Then, animals were submitted to several behavioral tasks. Compared to binge-drinking mice, the exercised + EtOH group exhibited diminished anxiolytic-related behaviors in the elevated plus-maze, enhanced exploratory activity in the open field, reduced preference for alcohol odor when another rewarding stimulus was present (social stimulus) and lower latency to start self-cleaning behaviors in the sucrose splash test. In contrast, other measurements such as habituation learning and working memory were not improved by exercise. Besides, exercise was not able to reduce alcohol consumption across the weeks. In conclusion, physical activity during adolescence and early adulthood could buffer certain neurobehavioral alterations associated with binge-drinking, despite not reducing the quantity of consumed alcohol.

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Section: Discussionmentioning

confidence: 99%

Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice

et al. 2020

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“…The hypothalamus actively controls aggressive and anxious behaviours by influencing hormone synthesis in adolescence. 31 Factors that affect HPA axis activities include circadian rhythm disturbances, stress and caffeine, particularly during adolescence. 32 The dysregulation of HPA axis activities during adolescence increases the risk of developing anxiety disorders.…”

Section: Hypothalamusmentioning

confidence: 99%

Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults

et al. 2021

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Adolescence is the peak period for the incidence of anxiety disorders. Recent findings have revealed the immaturity of neural networks underlying emotional regulation in this population. Brain vulnerability to anxiety in adolescence is related to the unsynchronised development of anxiety-relevant brain functional systems. However, our current knowledge on brain deficits in adolescent anxiety is mainly borrowed from studies on adults. Understanding adolescent-specific brain deficits is essential for developing biomarkers and brain-based therapies targeting adolescent anxiety. This article reviews and compares recent neuroimaging literature on anxiety-related brain structural and functional deficits between adolescent and adult populations, and proposes a model highlighting the differences between adolescence and adulthood in anxiety-related brain networks. This model emphasises that in adolescence the emotional control system tends to be hypoactivated, the fear conditioning system is immature, and the reward and stress response systems are hypersensitive. Furthermore, the striatum’s functional links to the amygdala and the prefrontal cortex are strengthened, while the link between the prefrontal cortex and the amygdala is weakened in adolescence. This model helps to explain why adolescents are vulnerable to anxiety disorders and provides insights into potential brain-based approaches to intervene in adolescent anxiety disorders.

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“…Neuronal activity in the latero-anterior hypothalamus (LAH) has previously been associated with aggressive behaviour in animals treated with androgens [ 33 ]. Building upon these findings, Morrison et al [ 34 ▪▪ ] found that serotonergic factors could be involved as blocking serotonin type-3 receptors in this region increased aggression, but decreased anxious behaviour in adolescent Syrian hamsters during androgen withdrawal. Typically, during androgen withdrawal, anxiety increases and aggression declines, suggesting that serotonin neural signalling within the LAH contributes to shifting between these behaviours.…”

Section: The Brain and Aggressionmentioning

confidence: 99%

Androgen abuse and the brain

Scarth

Bjørnebekk

2021

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review The purpose of this review is to examine the recent evidence regarding the effects of exogenous androgens on the brain. Understanding these effects is of high importance, as the consequences of androgens on the reproductive and endocrine system are well documented, while fewer studies have focused on the neural and cerebral consequences of androgen use. Recent findings Supraphysiological doses of androgens have been shown to contribute to neurodegeneration, decreased brain-derived neurotrophic factor, increased inflammation and decreased neuronal density in animal studies, which may correspond to changes in mood, cognition and aggression. Findings from human studies suggest that similar behavioural and cognitive deficits may occur as a result of prolonged use of androgens. Additional evidence suggests that androgen use, particularly in high doses, may contribute to brain ageing and cerebrovascular problems. Summary Findings from recent human and animal studies indicate that androgen use likely contributes to brain alterations, which may cause the frequently observed deficits in cognitive and emotional functioning. Although exogenous testosterone in appropriate doses for therapeutic purposes likely have some neurobiological benefits for certain populations, supraphysiological doses may cause multiple mental and physical health problems, indicating a need for additional large-scale studies in humans.

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Serotonin type-3 receptors differentially modulate anxiety and aggression during withdrawal from adolescent anabolic steroid exposure

Cited by 10 publications

References 87 publications

Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice

Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice

Adolescent anxiety disorders and the developing brain: comparing neuroimaging findings in adolescents and adults

Androgen abuse and the brain

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