Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism Is Not Associated With Paroxetine-Induced Ejaculation Delay in Dutch Men With Lifelong Premature Ejaculation

Janssen, Paddy K.C.; Zwinderman, Aeilko H.; Olivier, Berend; Waldinger, Marcel D.

doi:10.4111/kju.2014.55.2.129

Cited by 21 publications

(18 citation statements)

References 11 publications

(19 reference statements)

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“…The geometric mean of IELT has been commonly used in this field. 16,17 The mean difference between eIELT and sIELT was determined using the paired t test. Correlations between continuous variables were assessed using the Pearson correlation coefficient (r).…”

Section: Discussionmentioning

confidence: 99%

Can Estimated Intravaginal Ejaculatory Latency Time Be Used Interchangeably With Stopwatch-measured Intravaginal Ejaculatory Latency Time for the Diagnosis of Lifelong Premature Ejaculation?

Lee¹,

Cho²,

Lee³

et al. 2015

Urology

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Section: Discussionmentioning

confidence: 99%

Can Estimated Intravaginal Ejaculatory Latency Time Be Used Interchangeably With Stopwatch-measured Intravaginal Ejaculatory Latency Time for the Diagnosis of Lifelong Premature Ejaculation?

Lee¹,

Cho²,

Lee³

et al. 2015

Urology

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“…Although LPE has high prevelance, its pathophhysiology has not been clearly elucidated (Donatucci, ). Studies have shown that neurobiological (Waldinger, ), genetic (Janssen et al ., ), and psychological (McCabe et al ., ) factors may be the causative factors for LPE (Corona et al ., ).Fetal hormones may have an effect on the development of ejaculatory reflex, and LPE may be affected by intrauterine developmental process (Bolat et al ., ). Fetal androgen exposure tends to cause multiple diseases (Maldonado‐Cárceles et al ., ).…”

Section: Introductionmentioning

confidence: 97%

“…In 2014, the International Society of Sexual Medicine clarified the definition of PE, which includes the following criteria for lifelong PE (LPE) (Serefoglu et al, 2014): 1 Ejaculation that always or nearly always occurs before, or within about 1 min of vaginal penetration from the first sexual experience 2 Inability to delay ejaculation on all or nearly all vaginal penetrations 3 Negative personal consequences, such as distress, bother, frustration, and/or the avoidance of sexual intimacy Although LPE has high prevelance, its pathophhysiology has not been clearly elucidated (Donatucci, 2006). Studies have shown that neurobiological (Waldinger, 2002), genetic (Janssen et al, 2014), and psychological (McCabe et al, 2010) factors may be the causative factors for LPE (Corona et al, 2012).Fetal hormones may have an effect on the development of ejaculatory reflex, and LPE may be affected by intrauterine developmental process (Bolat et al, 2017). Fetal androgen exposure tends to cause multiple diseases (Maldonado-C arceles et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The relationship between anogenital distance and lifelong premature ejaculation

et al. 2019

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Background Many diseases have been associated with anogenital distance, as an indicator of intrauterine androgen exposure. Objectives The aim of this study was to investigate the association between lifelong premature ejaculation and anogenital distance. Materials and methods The study included 140 participants: 70 with lifelong premature ejaculation (group 1) and 70 without any ejaculatory complaints (group 2). Premature Ejaculation Diagnostic Tool and stopwatch intravaginal ejaculatory latency time were recorded from all participants in order to evaluate ejaculatory function. Two variants of anogenital distance were measured: anogenital distance (from anus to the posterior base of the scrotum) from anus to the posterior base of the scrotum and anogenital distance (from anus to the cephalad insertion of the penis) to the cephalad insertion of the penis. We compared differences between groups and correlations between anogenital distance variants and patients’ characteristics. Results The groups were similar in terms of age, BMI, and total testosterone levels. The mean anogenital distance (from anus to the posterior base of the scrotum) scores were 59.45 ± 10.76 vs. 55.02 ± 10.13 (p = 0.01), and anogenital distance (from anus to the cephalad insertion of the penis) scores were 128.37 ± 22.2 vs. 126.78 ± 16.21 (p = 0.63) in groups 1 and 2, respectively. Significant correlation was observed between anogenital distance (from anus to the posterior base of the scrotum) and Premature Ejaculation Diagnostic Tool scores (r = 0.199, p = 0.019) and intravaginal ejaculatory latency time (r = −0.185, p = 0.028). There were no statistically significant differences between anogenital distance (from anus to the posterior base of the scrotum) scores and total testosterone levels and between anogenital distance (from anus to the cephalad insertion of the penis) and Premature Ejaculation Diagnostic Tool scores or intravaginal ejaculatory latency time. Conclusions These results suggest that longer anogenital distance is associated with higher possibility of lifelong premature ejaculation. However, further studies are needed to confirm our results.

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“…In 69 patients with premature ejaculation treated with paroxetine, the 5‐HTTLPR S allele was more common in responders (i.e., more frequent delayed ejaculation, p<0.05) . To the contrary, in a study of 54 Dutch men with premature ejaculation treated with paroxetine, 5‐HTTLPR genotype was not associated with fold change in intravaginal ejaculator latency time (p=0.83) …”

Section: Resultsmentioning

confidence: 98%

“…46 To the contrary, in a study of 54 Dutch men with premature ejaculation treated with paroxetine, 5-HTTLPR genotype was not associated with fold change in intravaginal ejaculator latency time (p=0.83). 47 It is not surprising that results for this phenotype are conflicting, as sexual functioning is a complex phenotype, with potential for dysfunction in desire, arousal, orgasm, or satisfaction. Of the aforementioned studies, many examine only one sexual function domain and furthermore, SSRI effects and perhaps pharmacogenetic associations with sexual functioning manifest differently between men and women, which data from one study suggest.…”

Section: Sexual Dysfunction Adverse Eventsmentioning

confidence: 99%

Serotonin Transporter Gene Polymorphisms and Selective Serotonin Reuptake Inhibitor Tolerability: Review of Pharmacogenetic Evidence

2017

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Selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacotherapy for mood and anxiety disorders. The common mechanism of drugs in this class is antagonism of the serotonin transporter. Within the serotonin transporter gene SLC6A4, two polymorphic sites termed 5-HTTLPR and STin2 are proposed to have functional consequences and thus have been attractive candidates for pharmacogenetic studies of SSRI efficacy and tolerability. This review summarizes approximately 15 years of study of these polymorphisms as they relate to SSRI tolerability phenotypes. Four online databases (PubMed, Cochrane CENTRAL, PsycINFO, and PharmGKB) were searched for articles on polymorphisms of SLC6A4 including 5-HTTLPR and STin2 by using a systematic approach. Specific and general psychopharmacology terms, along with adverse effect and tolerability concepts, added to the search strategy. The Human Gene Mutation Database was checked for additional references. Forty studies met the inclusion criteria. While null and occasionally opposite associations are reported, the low expression 5-HTTLPR S allele is generally associated with greater adverse drug reaction burden during SSRI therapy. The most convincing evidence is in studies of antidepressant-induced mania and gastrointestinal adverse events. Studies of STin2 are sparse and have conflicting findings. In conclusion, the S allele of 5-HTTLPR may be predictive of increased adverse event burden, and this effect appears specific to certain classes of adverse events. Limitations and challenges in interpreting this body of evidence include assay errors, dissimilar grouping of genotypes, the role of ethnicity in associations, and study methodological differences. The clinical utility of serotonin transporter genotypes is not yet delineated but will ultimately depend on genotypic effects on both tolerability and efficacy of SSRIs.

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Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism Is Not Associated With Paroxetine-Induced Ejaculation Delay in Dutch Men With Lifelong Premature Ejaculation

Cited by 21 publications

References 11 publications

Can Estimated Intravaginal Ejaculatory Latency Time Be Used Interchangeably With Stopwatch-measured Intravaginal Ejaculatory Latency Time for the Diagnosis of Lifelong Premature Ejaculation?

Can Estimated Intravaginal Ejaculatory Latency Time Be Used Interchangeably With Stopwatch-measured Intravaginal Ejaculatory Latency Time for the Diagnosis of Lifelong Premature Ejaculation?

The relationship between anogenital distance and lifelong premature ejaculation

Serotonin Transporter Gene Polymorphisms and Selective Serotonin Reuptake Inhibitor Tolerability: Review of Pharmacogenetic Evidence

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