Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans

Graham, David P.; Helmer, Drew A.; Harding, Mark J.; Kosten, Thomas R.; Petersen, Nancy J.; Nielsen, David A.

doi:10.1016/j.jpsychires.2013.02.006

Cited by 44 publications

(34 citation statements)

References 54 publications

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“…Within the Rehabilomics framework, it is also important to consider biological or genetic effects that could be associated with PTD development, antidepressant use, or functional recovery. It will be important to examine how biomarkers (inflammation 68 , neurotrophins 69 ) or genetics (serotonin transporter 70,71 and related genes 72 ) that have previously shown relationships to PTD might influence PTD-cognition interactions. In addition, multicenter data collection in TBI, such as in the TBI Model Systems 73 , may allow evaluation of relationships between PTD and cognition using additional instruments like the Brief Test of Adult Cognition by Telephone 74 (a common data element 75 ) in order to examine relationships between cognition and depression post-TBI across instruments and in larger sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Effects of Depression and Antidepressant Use on Cognitive Deficits and Functional Cognition Following Severe Traumatic Brain Injury

Failla

Juengst

Graham

et al. 2016

Journal of Head Trauma Rehabilitation

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Objective To use a Rehabilomics framework to evaluate relations between post-TBI depression (PTD) and potential associated factors, including antidepressant use, on cognitive recovery following severe TBI. Participants Severe TBI survivors (n=154), recruited from a level 1 trauma center. Design Prospective cohort study with assessments at 6 and 12 months post-injury. Main Measures Patient Health Questionnaire-9 (PTD symptoms); cognitive composite score from a neuropsychological assessment battery (cognitive impairment); and Functional Independence Measure–Cognition (FIM-Cog, self-reported functional cognition). Results Individuals with and without PTD did not differ with respect to cognitive impairment. However, antidepressant use, regardless of PTD status, was associated with cognitive impairment. Individuals with PTD reported lower FIM-Cog scores at both time-points compared to those without PTD. In a post-hoc longitudinal analysis, individuals with late-onset PTD had worse cognitive impairment. Conclusion These results suggest antidepressant use impairs cognition among individuals without PTD. Also, PTD does not directly affect cognitive impairment but may affect functional cognitive limitations through self-evaluation and apathy/motivation factors.

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Section: Discussionmentioning

confidence: 99%

Effects of Depression and Antidepressant Use on Cognitive Deficits and Functional Cognition Following Severe Traumatic Brain Injury

Failla

Juengst

Graham

et al. 2016

Journal of Head Trauma Rehabilitation

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“…COMT Val158Met polymorphism (rs4680) was genotyped utilizing TaqMan ® SNP Genotyping Assay as described by the manufacturer (Applied Biosystems, Carlsbad, CA). For the purposes of evaluating a potential protective benefit of the Met 158 allele, Met 158 /Met 158 and Met 158 /Val 158 were combined as a single group as previously described for COMT [42–45], and other genetic polymorphisms in TBI [46–48]. Therefore, for data recording and all figures this group is referred to as Met 158 .…”

Section: Methodsmentioning

confidence: 99%

COMT ValMet polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury

Winkler

Yue

Ferguson

et al. 2017

Journal of Clinical Neuroscience

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“…COMT Val158Met polymorphism ( rs4680 ) was genotyped utilizing the TaqMan ® SNP Genotyping Assay as described by the manufacturer (Applied Biosystems, Carlsbad, CA, Assay ID# C_25746809_50). For the purpose of evaluating a potential protective benefit of the Met 158 allele, Met 158 / Met 158 and Met 158 / Val 158 were combined as a single group as previously described for COMT [37–40] and other genetic polymorphisms in TBI [41–43]. Therefore, for data reporting and all figures, this group is referred to as Met 158 .…”

Section: Methodsmentioning

confidence: 99%

COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury

et al. 2015

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Mild traumatic brain injury (mTBI) results in variable clinical outcomes, which may be influenced by genetic variation. A single-nucleotide polymorphism in catechol-o-methyltransferase (COMT), an enzyme which degrades catecholamine neurotransmitters, may influence cognitive deficits following moderate and/or severe head trauma. However, this has been disputed, and its role in mTBI has not been studied. Here, we utilize the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study to investigate whether the COMT Val158Met polymorphism influences outcome on a cognitive battery 6 months following mTBI—Wechsler Adult Intelligence Test Processing Speed Index Composite Score (WAIS-PSI), Trail Making Test (TMT) Trail B minus Trail A time, and California Verbal Learning Test, Second Edition Trial 1–5 Standard Score (CVLT-II). All patients had an emergency department Glasgow Coma Scale (GCS) of 13–15, no acute intracranial pathology on head CT, and no polytrauma as defined by an Abbreviated Injury Scale (AIS) score of ≥3 in any extracranial region. Results in 100 subjects aged 40.9 (SD 15.2) years (COMT Met158/Met158 29 %, Met158/Val158 47 %, Val158/Val158 24 %) show that the COMT Met158 allele (mean 101.6±SE 2.1) associates with higher nonverbal processing speed on the WAIS-PSI when compared to Val158/Val158 homozygotes (93.8±SE 3.0) after controlling for demographics and injury severity (mean increase 7.9 points, 95 % CI [1.4 to 14.3], p=0.017). The COMT Val158Met polymorphism did not associate with mental flexibility on the TMT or with verbal learning on the CVLT-II. Hence, COMT Val158Met may preferentially modulate nonverbal cognition following uncomplicated mTBI.

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Serotonin transporter genotype and mild traumatic brain injury independently influence resilience and perception of limitations in veterans

Cited by 44 publications

References 54 publications

Effects of Depression and Antidepressant Use on Cognitive Deficits and Functional Cognition Following Severe Traumatic Brain Injury

Effects of Depression and Antidepressant Use on Cognitive Deficits and Functional Cognition Following Severe Traumatic Brain Injury

COMT ValMet polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury

COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury

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