Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms in Croatian suicide victims

Hranilović, Dubravka; Štefulj, Jasminka; Furač, Ivana; Kubat, Milovan; Balija, Melita; Jernej, Branimir

doi:10.1016/s0006-3223(03)00179-3

Cited by 65 publications

(39 citation statements)

References 35 publications

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“…However, a combined analysis of the 5-HTTLPR and VNTR-2 provided evidence towards an increase of 5-HTTLPR L-allele and VNTR-2 allele 10 in the suicide victim group, which was however of low significance. 107 …”

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confidence: 99%

Genetics of suicide

2006

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The concept that genetic factors contribute to the complex trait of suicidal behaviour has stimulated much work aimed at identifying susceptibility genes. So far molecular genetic studies focused on the serotonergic pathway as the intent to die and the lethality of suicide acts were related to the serotonergic system. Two genes have so far emerged as being involved in the vulnerability for suicidality: first, the intronic polymorphisms (A218C or A779C) of the tryptophan hydroxylase 1 (TPH1) gene, which was suggested as a quantitative risk factor for suicidal behaviour; second, the insertion/deletion polymorphism of the serotonin transporter gene (5-HTTLPR), which does not seem to be involved in general suicidal behaviour, but in violent and repeated suicide attempts. The data have further shown that the MAOA gene, which is consistently associated with impulsive-aggressive personality traits, is not related to suicide but might induce violent methods in subjects with other suicide risk factors. Predominantly negative were the findings with any type of the serotonin receptors and inconsistent with catecholamine-synthesizing and -metabolizing enzymes or with the dopaminergic receptors. This paper reviews the status of current knowledge in this area, points to the weakness of the investigations and presents new approaches beyond the serotonergic system.

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confidence: 99%

Genetics of suicide

2006

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“…Our earlier research has also given some support to this concept (Hranilovic et al, 2003;Jernej et al, 2004;Stefulj et al, 2006). Therefore, association studies on genes encoding synaptic proteins of this transmitter, including recently discovered Tph2, should be encouraged, with negative reports being as important as positive ones in obtaining realistic picture of true genetic influences.…”

Section: Discussionmentioning

confidence: 90%

Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide

Štefulj

Mokrović

Hranilović

et al. 2011

Psychiatry Research

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“…Additionally, significant differences were observed between patients with unipolar disorder and controls in the proportion of individuals who had allele 9 Ogilvie et al, 1996]. Finally, an increased frequency of the 10 allele of this intron polymorphism together with the long allele of the promoter polymorphism of the serotonin transporter gene was observed in a suicide cohort of Slavic ethnicity (P 5 0.0112) [Hranilovic et al, 2003]. Thus, most of the evidence suggests that this polymorphism is functional and may influence affective disorders.…”

Section: Serotonintransporter (Slc6a4 Htt Sert)mentioning

confidence: 89%