Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts

Daray, Federico Manuel; Arena, Ángeles Romina; Armesto, Arnaldo; Rodante, Demián; Puppo, Soledad; Vidjen, Patricia; Portela, Alicia; Grendas, Leandro Nicolás; Errasti, Andrea Emilse

doi:10.1016/j.eurpsy.2018.07.001

Cited by 14 publications

(7 citation statements)

References 71 publications

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“…Patients with low-expression 5HTTLPR genotypes and childhood trauma have an increased risk of suicidal behavior [63]. Some studies support an increased risk of suicide attempts in depressed patients with the S allele [64][65][66], though other studies have not found this association [67][68][69][70][71]. Sarmiento-Hernández et al [20] conclude that the higher S allele frequency in the studied population reinforces the hypothesis that the 5HTTLPR variants play an essential role in the development of suicidal behavior in depressed adolescents, regardless of the presence of another psychiatric comorbidity [20].…”

Section: Httlpr Variant and Mdd Risk Factorsmentioning

confidence: 99%

5HTTLPR Genetic Variant and Major Depressive Disorder: A Review

Siqueira

Silva

Ferreira

et al. 2020

Genes

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Major Depressive Disorder (MDD) is a disease that involves biological, psychological, and social interactions. Studies have shown the importance of genetics contribution to MDD development. The SCL6A4 protein (5HTTLPR) functions transporting serotonin, a neurotransmitter linked to mood and emotion, to the synaptic cleft. Hence, this study seeks, through a literature review, a better comprehension of the 5HTTLPR genetic variant association with MDD. For this purpose, a search was performed on the Virtual Health Library Portal for articles that related 5HTTLPR to MDD. Most of the articles found were conducted in the American continent, with one (1) study implemented in Brazil. 5HTTLPR associations were found regarding changes in the nervous system, pharmacology, and risk factors seen in MDD patients. When verifying the allelic distribution, the S allele had a higher frequency in most of the studies analyzed. Despite not finding a commonality in the different studies, the tremendous genetic variation found demonstrates the MDD complexity. For this reason, further studies in diverse populations should be conducted to assist in the understanding and treatment of the disease.

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Section: Httlpr Variant and Mdd Risk Factorsmentioning

confidence: 99%

5HTTLPR Genetic Variant and Major Depressive Disorder: A Review

Siqueira

Silva

Ferreira

et al. 2020

Genes

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“…Likewise, postmortem brain tissue biochemical analysis has shown a reduction of SERT in the frontal cortex, hippocampus, and putamen; however, contradictory outcomes have been observed depending on the brain region analyzed ( Purselle and Nemeroff, 2003 ; Steinberg et al., 2019 ). Besides, polymorphism at the transporter gene, particularly the polymorphism 5-HTTLPR predicts a three times higher-risk suicide compared to other alleles independent of age and sex ( Daray et al., 2018 ; Nielsen et al., 2019 ; Sarmiento-Hernández et al., 2019 ).…”

Section: Neurochemical and Neurobiological Findings Suicidal Behaviormentioning

confidence: 99%

Psychological and neurobiological aspects of suicide in adolescents: Current outlooks

Vargas-Medrano

Diaz-Pacheco

Castaneda

et al. 2020

Brain, Behavior, & Immunity - Health

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Suicidality is one of the leading causes of death among young adults in the United States and represents a significant health problem worldwide. The suicide rate among adolescents in the United States has increased dramatically in the latest years and has been accompanied by considerable changes in youth suicide, especially among young girls. Henceforth, we need a good understanding of the risk factors contributing to suicidal behavior in youth. An explanatory model for suicidal behavior that links clinical and psychological risk factors to the underlying neurobiological, neuropsychological abnormalities related to suicidal behavior might predict to help identify treatment options and have empirical value. Our explanatory model proposes that developmental, biological factors (genetics, proteomics, epigenetics, immunological) and psychological or clinical (childhood adversities) may have causal relevance to the changes associated with suicidal behavior. In this way, our model integrates findings from several perspectives in suicidality and attempts to explain the relationship between various neurobiological, genetic, and clinical observations in suicide research, offering a comprehensive hypothesis to facilitate understanding of this complex outcome. Unraveling the knowledge of the complex interplay of psychological, biological, sociobiological, and clinical risk factors is highly essential, concerning the development of effective prevention strategy plans for suicidal ideation and suicide.

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“…Previous studies published contradictory findings, with some reporting females to be at increased risk for suicide after discharge [4,14,15], whereas others found males to be at an increased risk [3]. When investigating recurrent suicidal behavior, no significant sex difference was reported [16]. Further, previous studies were based on national or regional register data from single countries only.…”

Section: Introductionmentioning

confidence: 96%

The effect of sex on suicide risk during and after psychiatric inpatient care in 12 countries—An ecological study

et al. 2020

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Background. Suicide risk in patients is markedly elevated during psychiatric inpatient care, as well as after discharge. However, it is unclear whether, and to what extent, this increased suicide risk varies between sex. Thus, the aim of this study was to analyze sex differences for suicides during and after psychiatric hospitalization in various countries. Methods. National suicide mortality rates and inpatient-related suicide rates (three intervals: during psychiatric inpatient treatment, 1 month, and 1 year after discharge) from 12 countries for 2000-2016 were analyzed, and a logistic model was used to quantify the effect of sex. Results. Persons admitted to or discharged from psychiatric inpatient care exhibited significantly increased rates of suicide compared to those in the general population. Furthermore, increase of suicide risk was significantly higher for females than for males for all investigated time intervals (inpatient suicide odds ratio [OR] 1.85; suicide within 1 month after discharge-OR 1.94; suicide within 1 year after discharge-OR 2.04). Conclusion. Analysis confirmed the time during and after psychiatric inpatient care to be significantly associated with an elevated risk for suicide. Further, a significant sex effect was observed, with females in this population being at a proportionally higher risk for suicide during psychiatric inpatient treatment as well as the year following discharge. Our study implicates that more effective suicide preventive measures during inpatient stay, focusing on female patients, are needed.

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Serotonin transporter gene polymorphism as a predictor of short-term risk of suicide reattempts

Abstract: The 5-HTTLPR polymorphisms predicted short-term risk of suicidal reattempt independently of age and sex. L-carriers have almost three times more risk of relapse when compared with SS carriers.

Cited by 14 publications

References 71 publications

5HTTLPR Genetic Variant and Major Depressive Disorder: A Review

5HTTLPR Genetic Variant and Major Depressive Disorder: A Review

Psychological and neurobiological aspects of suicide in adolescents: Current outlooks

The effect of sex on suicide risk during and after psychiatric inpatient care in 12 countries—An ecological study

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