Serotonin transporter binding after recovery from eating disorders

Bailer, Ursula F.; Frank, Guido; Henry, Shannan; Price, Julie C.; Meltzer, Carolyn C.; Becker, Carl; Ziolko, Scott K.; Mathis, Chester A.; Wagner, Angela; Barbarich-Marsteller, Nicole C.; Putnam, Karen; Kaye, Walter H.

doi:10.1007/s00213-007-0896-7

Cited by 86 publications

(66 citation statements)

References 76 publications

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“…While 5-HTT levels in AN and AN-BN individuals are comparable to controls (Table 1), 5-HTT differences have been observed when AN and AN-BN subgroups are compared. 57 These findings may be consistent with a recent study 58 showing that the S-allele of the 5-HTTLPR (serotonin-transporter-linked polymorphic region in SLC6A4) genotype increases the risk susceptibility for diagnostic crossover over time in ill subjects.…”

Section: Alterations In the Serotonergic Systemsupporting

confidence: 91%

Nothing Tastes as Good as Skinny Feels: the Neurobiology of Anorexia Nervosa

Kaye¹,

Wierenga²,

Bailer³

et al. 2014

FOC

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123

176

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Individuals with anorexia nervosa (AN) engage in relentless, restrictive eating and often become severely emaciated. Because there are no proven treatments, AN has high rates of relapse, chronicity, and death. Those with AN tend to have childhood temperament and personality traits, such as anxiety, obsessions, and perfectionism, which may reflect neurobiological risk factors for developing AN. Restricted eating may be a means of reducing negative mood caused by skewed interactions between serotonin aversive or inhibitory and dopamine reward systems. Brain imaging studies suggest altered eating is a consequence of dysregulated reward, and/or awareness of homeostatic needs, perhaps related to enhanced executive ability to inhibit incentive motivational drives. Understanding the neurobiology of this disorder is likely to be important for developing more effective treatments.

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Section: Alterations In the Serotonergic Systemsupporting

confidence: 91%

Nothing Tastes as Good as Skinny Feels: the Neurobiology of Anorexia Nervosa

Kaye¹,

Wierenga²,

Bailer³

et al. 2014

FOC

Self Cite

123

176

View full text Add to dashboard Cite

show abstract

“…41 The results suggested that (1) EDs, AN and BN, have neurobiological traits due to persistent disturbance of 5-HTT function, and 2) there are changes in serotonergic function among subtypes of EDs in different brain areas regulating mood and impulse control. Integration of imaging and genetic studies will provide clear direction for understand- ing genetic vulnerability to dysfunction in neural circuits related to EDs.…”

Section: Discussionmentioning

confidence: 97%

Association between serotonin transporter gene polymorphism and eating disorders: A meta‐analytic study

Lin

2010

Intl J Eating Disorders

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“…Furthermore, stress has been shown to downregulate serotonin receptors in the raphe nuclei [42]. Depletion of central serotonin is also found in several psychiatric disorders including obsessivecompulsive disorder (OCD) [43], depression [44], eating disorders [45], and anxiety disorders [46]. Accordingly, attachment-related anxiety is thought to increase insecure feelings towards the relationship with a partner.…”

Section: Discussionmentioning

confidence: 99%

Brainstem Activity Predicts Attachment-Related Anxiety

Kikuchi¹,

Matsutani²,

Mori³

et al. 2018

Neuropsychiatry

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Objective: Attachment security serves as a critical resource for individuals to preserve relationship quality. However, insecure attachment interrupts it and seriously influences mental/physical health. Therefore, it is important to clarify the correlations between brain activity and attachment-related anxiety and its avoidance. Methods:We investigated these correlations in healthy male subjects by using functional magnetic resonance imaging (fMRI) while they were viewing their partner.Results: The brain regions that were significantly activated for the partner vs. unknown females were the anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), dorsal raphe nucleus (DRN), pontine raphe nucleus (PRN), and locus coeruleus (LC) in a whole-brain analysis. A region of interest (ROI) analysis showed that the DRN, periaqueductal grey (PAG), hypothalamus, anterior insula (AIC), substantia nigra/ventral tegmental area (SN/VTA), ACC, PCC and intraparietal sulcus (IPS) were significantly activated. Furthermore, activity in the DRN, SN/VTA, and LC negatively correlated with attachment-related anxiety.Conclusions: There were individual differences in the correlations between the brainstem activity and attachment-related anxiety, although brain activity in our subjects was more similar to that observed in long-term intense romantic love and maternal love compared to that in early-stage romantic love. These brainstem regions are the primary sites of neurotransmitters which modulate basic functions of survival, and also play key roles for maintenance of secure relationships with a partner. This finding might be useful to assessment of the risk of breakdowns by factors of the attachment style.

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Serotonin transporter binding after recovery from eating disorders

Abstract: Divergent 5-HTT activity in subtypes of eating disorder subjects may provide important insights as to why these groups have differences in affective regulation and impulse control.

Cited by 86 publications

References 76 publications

Nothing Tastes as Good as Skinny Feels: the Neurobiology of Anorexia Nervosa

Nothing Tastes as Good as Skinny Feels: the Neurobiology of Anorexia Nervosa

Association between serotonin transporter gene polymorphism and eating disorders: A meta‐analytic study

Brainstem Activity Predicts Attachment-Related Anxiety

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