“…For decades, altered serotonin signaling has been implicated in the pathophysiology of hypertension, preeclampsia, and neurodevelopment disorders in infants [5,[7][8][9][10][11][12][13][14]. Additionally, serotonin's effects on pregnancy outcomes have been studied for decades; however, more recently, the role of serotonin in processes including embryonic and fetal brain development, placental function, intrauterine growth restriction (IUGR), and neonatal health have been in the spotlight [13,[15][16][17][18][19][20] given the increasing maternal use of medications that alter serotonin signaling, including selective serotonin reuptake inhibitors (SSRI). The possible detrimental effects of serotonin on pregnancy and neonatal outcomes support the need for a comprehensive understanding of how serotonin and medications that modulate serotonin signaling are associated with the pathophysiology of multiple conditions, such as gestational hypertension, preeclampsia, IUGR, autism spectrum disorder, preterm birth, and sudden infant death syndrome.…”