Serotonin Syndrome with Escitolapram and Concomitant Use of Cocaine: A Case Report

Malik, Hamood Ur-Rehman; Kumar, Krishan

doi:10.4137/ccrep.s9540

Cited by 11 publications

(8 citation statements)

References 9 publications

(37 reference statements)

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“…patient suffering from SS secondary to moclobemide-clomipramine overdose 30 as well as in an individual with SS from cocaine use while taking escitalopram. 31 The clinical course of our patient reveals the pharmacologic and physiologic complexity associated with SSRIs and identifies an otherwise unknown complication of sertraline use in a child. The strength of association of this particular adverse drug reaction is supported by causality tools such as the Hill 32 criteria and the Naranjo et al 33 probability.…”

Section: Figurementioning

confidence: 79%

Sertraline-Induced Rhabdomyolysis, Trismus, and Cardiac Arrest in a Child

Holmberg¹,

Arteaga²,

Schiltz³

et al. 2018

Pediatrics

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Selective serotonin reuptake inhibitors are a commonly used and often effective class of medications in the treatment of mood disorders such as anxiety and depression. Sertraline (1S,4S-N-methyl-4-[3,4-dichlorophenyl]-1,2,3,4-tetrahydro-1-naphthylamine [Zoloft; Pfizer, New York City, NY]) is a frequently used selective serotonin reuptake inhibitor that has shown efficacy in children, adolescents, and adults. We report the case of a 13-year-old boy with sertraline-induced rhabdomyolysis and renal failure, trismus, and cardiopulmonary arrest. Pharmacogenetic testing later revealed our patient had serotonin transporter polymorphisms and enzymatic alterations that put him at risk for increased levels of sertraline and greater likelihood for untoward side effects.

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Section: Figurementioning

confidence: 79%

Sertraline-Induced Rhabdomyolysis, Trismus, and Cardiac Arrest in a Child

Holmberg¹,

Arteaga²,

Schiltz³

et al. 2018

Pediatrics

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“…Kumar, et al reported a case of SS precipitated by intentional overdose on escitalopram and concomitant use of cocaine [11]. Their case also had spontaneous resolution of symptoms after 24 hours of IV fluids and benzodiazepine and did not require cyproheptadine.…”

Section: Discussionmentioning

confidence: 99%

Serotonin Syndrome on a Low Dose SSRI and an Atypical Antipsychotic Agent in a Patient with Cirrhosis of Liver

Sharma¹,

Hemraj²

2022

J Psychiatry Treat Res

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We present a case of 50-year-old male patient with a known history of cirrhosis of liver, hepatic encephalopathy, hepatitis C, stimulant use disorder, methamphetamine type and major depressive disorder, with psychotic features who presented to the emergency department for altered mental status.Patient was previously admitted 5 days ago for acute encephalopathy to medicine service and after stabilization, transferred to a psychiatry inpatient service for worsening depression. He was started on Lexapro 5 mg and Zyprexa 5 mg for major depressive disorder with psychotic features and at the time of presentation he had already been taking these medications for the past 10 days.When the patient was seen at the ER, he was lying in

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“…Whilst there is no level 3 or higher evidence to support their use in SS, both these agents were given in accordance with current UK NPIS Toxbase guidance. After reviewing recently published case reports, we note that patients with serotonin syndrome present in a wide variety of ways, but where recognition and management is prompt, recovery is usually complete ( Table 4 ) [ 10 , 12 - 15 ].…”

Section: Discussionmentioning

confidence: 99%

Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review

Dean-Paccagnella

Creed

Kakollu

et al. 2018

BEAT

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Drug induced hyperthermia is a rare presentation which can rapidly lead to gross metabolic abnormality and death. These presentations are further complicated by the wide range of potentially causative agents. We present a case of rigidity and hyperthermia, following overdose of an initially unknown substance leading to challenging management decisions in the Emergency Department. This case was later identified as Serotonin Syndrome. The patient presented with trismus which was managed with rapid sequence induction of anaesthesia to allow airway protection. On extubation a significant degree of laryngeal oedema complicated weaning, a possible complication of Serotonin Syndrome not previously described in the literature. We discuss the pathophysiology of Serotonin Syndrome, important differentials and practical considerations in managing hypertonicity of unknown origin in a young person.

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Serotonin Syndrome with Escitolapram and Concomitant Use of Cocaine: A Case Report

Cited by 11 publications

References 9 publications

Sertraline-Induced Rhabdomyolysis, Trismus, and Cardiac Arrest in a Child

Sertraline-Induced Rhabdomyolysis, Trismus, and Cardiac Arrest in a Child

Serotonin Syndrome on a Low Dose SSRI and an Atypical Antipsychotic Agent in a Patient with Cirrhosis of Liver

Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review

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